Crystal Structure
Crystallisation Method:EM
Corresponding Chain:A
Sequence Length:1-571
Detail: Struture Info
Drug Transporter (DT) Information
| General Information of DT | |||||
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| DT ID | DTD0353 | ||||
| Gene Name | SLC40A1 | ||||
| Protein Name | Iron-regulated transporter 1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
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| Synonyms | FPN1; Ferroportin-1; HFE4; IREG1; MST079; MSTP079; MTP1; SLC11A3; SLC40A1; Solute carrier family 40 member 1 | ||||
| DT Family | Ferroportin (FPN) Family ; | ||||
| Tissue Specificity | Detected in erythrocytes (at protein level).Expressed in placenta, intestine, muscle and spleen. | ||||
| Function | This transporter may be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). | ||||
| Endogenous Substrate(s) | Co2+; Cu2+; Mn2+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Iron-regulated transporter 1 |
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(β) Cell Distribution Level of Iron-regulated transporter 1 |
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(γ) Organelle Distribution Level of Iron-regulated transporter 1 |
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Regulatory Variability Data of This DT |
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(α) Microbiota Influence of Iron-regulated transporter 1 |
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(β) Post-translational Modification of Iron-regulated transporter 1 |
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(γ) Transcriptional Regulation of Iron-regulated transporter 1 |
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(δ) Epigenetic Regulation of Iron-regulated transporter 1 |
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(ε) Exogenous Modulation of Iron-regulated transporter 1 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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(γ) Outward/inward-facing Conformation |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Iron-regulated transporter 1 |
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(β) Disease-specific Protein Abundances of Iron-regulated transporter 1 |
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(γ) Species- and Tissue-specific DT Abundances |
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| Molecular Transporting Profile of This DT | |||||
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Full List of Drug(s) Transported by This DT |
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Withdrawn, Discontinued or Preclinical Drug |
Click to Show/Hide the Full List of Drug: 1 Drugs in Total | ||||
| Drug Name | Highest Status | Detail | Indication | ICD 11 | Ref |
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Zinc salts
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Preclinical | Drug Info | Arthritis | FA5Z | [1] |
| References | |||||
| 1 | Ferroportin-mediated iron transport: expression and regulation. Biochim Biophys Acta. 2012 Sep;1823(9):1426-33. | ||||
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