Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0353 Transporter Info
Gene Name	SLC40A1
Transporter Name	Iron-regulated transporter 1
Gene ID	30061
UniProt ID	Q9NP59

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 5 TF(s) Regulating This DT
BACH1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC40A1 gene in ferroptosis condition			[1]
TF Protein Name	Transcription regulator protein BACH1		Transcription Factor Info
Studied Phenotype	Ferroptosis [ICD11: N.A.]
Tissue	Embryo
Related DT Changes	Down regulating
Experimental Material	C57BL/6J Bach1KO mice
Detailed Description	Transcription regulator protein BACH1 (BACH1) has been reported to repress the transcription of SLC40A1 gene in ferroptosis condition, which leads to a decreased expression of the drug transporter Iron-regulated transporter 1.
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC40A1 gene			[2]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC40A1 gene, which in turn affects the expression or function of the drug transporter Iron-regulated transporter 1.
CEBPD		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC40A1 gene			[3]
TF Protein Name	CCAAT/enhancer-binding protein delta		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein delta (CEBPD) can directly bind to the SLC40A1 gene, which in turn affects the expression or function of the drug transporter Iron-regulated transporter 1.
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC40A1 gene			[4]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC40A1 gene, which in turn affects the expression or function of the drug transporter Iron-regulated transporter 1.
NFE2L2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC40A1 gene in ovarian endometrioid adenocarcinoma condition			[5]
TF Protein Name	Nuclear factor erythroid 2-related factor 2		Transcription Factor Info
Affected Drug/Substrate	Cisplatin
Studied Phenotype	Ovarian endometrioid adenocarcinoma [ICD11: 2C73.01]
Tissue	Ovary
Related DT Changes	Down regulating
Experimental Material	Human ovarian endometrioid adenocarcinoma cells (A2780)
Detailed Description	Nuclear factor erythroid 2-related factor 2 (NFE2L2) has been reported to repress the transcription of SLC40A1 gene in ovarian endometrioid adenocarcinoma condition, which leads to a decreased expression of the drug transporter Iron-regulated transporter 1.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
EPAS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC40A1 gene in health condition			[6]
TF Protein Name	Endothelial PAS domain-containing protein 1		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Related DT Changes	Up regulating
Detailed Description	Endothelial PAS domain-containing protein 1 (EPAS1), influenced by the generated by Lactobacillus reuteri, has been reported to activate the transcription of SLC40A1 gene in health condition, which leads to an increased expression of the drug transporter Iron-regulated transporter 1.
TCF4		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC40A1 gene in colorectal cancer condition			[7]
TF Protein Name	Transcription factor 4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor 4 (TCF4) has been reported to activate the transcription of SLC40A1 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter Iron-regulated transporter 1.
Transcriptional Phenomenon2	Binding to SLC40A1 gene in glioblastoma multiforme condition			[8]
TF Protein Name	Transcription factor 4		Transcription Factor Info
Affected Drug/Substrate	Temozolomide
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor 4 (TCF4) has been reported to bind to the transcription of SLC40A1 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Iron-regulated transporter 1.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
AR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC40A1 gene in prostate cancer condition			[9]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Androgen receptor (AR) has been reported to activate the transcription of SLC40A1 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Iron-regulated transporter 1.
HNF4A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC40A1 gene in health condition			[10]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC40A1 gene in health condition, which leads to an affected expression of the drug transporter Iron-regulated transporter 1.
PPARD		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC40A1 gene in myofibroblast condition			[11]
TF Protein Name	Peroxisome proliferator-activated receptor delta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of SLC40A1 gene in myofibroblast condition, which leads to a decreased expression of the drug transporter Iron-regulated transporter 1.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
GATA1		Click to Show/Hide to Show 3 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC40A1 gene in hematopoiesis condition			[12]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC40A1 gene in hematopoiesis condition, which leads to an affected expression of the drug transporter Iron-regulated transporter 1.
Transcriptional Phenomenon2	Binding to SLC40A1 gene in megakaryocytes condition			[13]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC40A1 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Iron-regulated transporter 1.
Transcriptional Phenomenon3	Direct binding to SLC40A1 gene			[3]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Tissue	Blood; Bone marrow; Liver; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Erythroid transcription factor (GATA1) can directly bind to the SLC40A1 gene, which in turn affects the expression or function of the drug transporter Iron-regulated transporter 1.
GATA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC40A1 gene in hematopoiesis condition			[12]
TF Protein Name	Endothelial transcription factor GATA-2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Endothelial transcription factor GATA-2 (GATA2) has been reported to activate the transcription of SLC40A1 gene in hematopoiesis condition, which leads to an increased expression of the drug transporter Iron-regulated transporter 1.
GATA4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC40A1 gene in gastric cancer condition			[14]
TF Protein Name	Transcription factor GATA-4		Transcription Factor Info
Affected Drug/Substrate	Metformin
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor GATA-4 (GATA4) has been reported to activate the transcription of SLC40A1 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Iron-regulated transporter 1.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC40A1 gene			[4]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC40A1 gene, which in turn affects the expression or function of the drug transporter Iron-regulated transporter 1.
PRDM14		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC40A1 gene			[15]
TF Protein Name	PR domain zinc finger protein 14		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	PR domain zinc finger protein 14 (PRDM14) can directly bind to the SLC40A1 gene, which in turn affects the expression or function of the drug transporter Iron-regulated transporter 1.
ZNF217		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC40A1 gene in breast cancer condition			[16]
TF Protein Name	Zinc finger protein 217		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Zinc finger protein 217 (ZNF217) has been reported to bind to the transcription of SLC40A1 gene in breast cancer condition, which leads to an affected expression of the drug transporter Iron-regulated transporter 1.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
NANOG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC40A1 gene in health condition			[17]
TF Protein Name	Homeobox protein NANOG		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Homeobox protein NANOG (NANOG) has been reported to bind to the transcription of SLC40A1 gene in health condition, which leads to an affected expression of the drug transporter Iron-regulated transporter 1.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
FOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC40A1 gene			[15]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Embryo; Liver; Lung; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC40A1 gene, which in turn affects the expression or function of the drug transporter Iron-regulated transporter 1.
FOXA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC40A1 gene			[2]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC40A1 gene, which in turn affects the expression or function of the drug transporter Iron-regulated transporter 1.
FOXM1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC40A1 gene in breast cancer condition			[18]
TF Protein Name	Forkhead box protein M1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Forkhead box protein M1 (FOXM1) has been reported to activate the transcription of SLC40A1 gene in breast cancer condition, which leads to an increased expression of the drug transporter Iron-regulated transporter 1.
FOXP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC40A1 gene			[15]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Tissue	Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein P1 (FOXP1) can directly bind to the SLC40A1 gene, which in turn affects the expression or function of the drug transporter Iron-regulated transporter 1.
Class3.4: Heat shock factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
HSF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC40A1 gene in ferroptosis condition			[19]
TF Protein Name	Heat shock factor protein 1		Transcription Factor Info
Studied Phenotype	Ferroptosis [ICD11: N.A.]
Tissue	Heart
Related DT Changes	Down regulating
Experimental Material	Hsf1 mice
Detailed Description	Heat shock factor protein 1 (HSF1) has been reported to repress the transcription of SLC40A1 gene in ferroptosis condition, which leads to a decreased expression of the drug transporter Iron-regulated transporter 1.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
ELK3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to MIR155HG gene in hypoxia condition			[20]
TF Protein Name	ETS domain-containing protein Elk-3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	ETS domain-containing protein Elk-3 (ELK3) has been reported to bind to the transcription start site of the MIR155HG gene in hypoxia condition, which leads to an affected expression of the drug transporter Iron-regulated transporter 1.
FLI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC40A1 gene			[4]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC40A1 gene, which in turn affects the expression or function of the drug transporter Iron-regulated transporter 1.
MYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC40A1 gene			[3]
TF Protein Name	Transcriptional activator Myb		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional activator Myb (MYB) can directly bind to the SLC40A1 gene, which in turn affects the expression or function of the drug transporter Iron-regulated transporter 1.
TF Superclass4: Other all-alpha-helical DNA-binding domains
Class4.1: High-mobility group domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SOX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC40A1 gene in colorectal cancer condition			[21]
TF Protein Name	Transcription factor SOX-2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor SOX-2 (SOX2) has been reported to activate the transcription of SLC40A1 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter Iron-regulated transporter 1.
TF Superclass6: Immunoglobulin fold
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
TP53		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC40A1 gene in atherosclerosis condition			[22]
TF Protein Name	Cellular tumor antigen p53		Transcription Factor Info
Studied Phenotype	Atherosclerosis [ICD11: BD40]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Cellular tumor antigen p53 (TP53) has been reported to activate the transcription of SLC40A1 gene in atherosclerosis condition, which leads to an increased expression of the drug transporter Iron-regulated transporter 1.
TP63		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC40A1 gene in epithelial to mesenchymal transition condition			[23]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC40A1 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Iron-regulated transporter 1.
Class6.7: Grainyhead domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GRHL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC40A1 gene			[2]
TF Protein Name	Grainyhead-like protein 2 homolog		Transcription Factor Info
Tissue	Breast; Bronchus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC40A1 gene, which in turn affects the expression or function of the drug transporter Iron-regulated transporter 1.
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold
Class7.1: SMAD/NF-1 DNA-binding domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SMAD4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC40A1 gene in epithelial ovarian cancer condition			[24]
TF Protein Name	Mothers against decapentaplegic homolog 4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC40A1 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Iron-regulated transporter 1.

References
1	Ferroptosis is controlled by the coordinated transcriptional regulation of glutathione and labile iron metabolism by the transcription factor BACH1. J Biol Chem. 2020 Jan 3;295(1):69-82.
2	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-285. (ID:ENSG00000138449)
3	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
4	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
5	Nrf2 induces cisplatin resistance via suppressing the iron export related gene SLC40A1 in ovarian cancer cells. Oncotarget. 2017 Jul 25;8(55):93502-93515.
6	Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis. Cell Metab. 2020 Jan 7;31(1):115-130.e6.
7	Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. Mol Cell Biol. 2008;28(8):2732-44.
8	Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
9	Integrative analysis of FOXP1 function reveals a tumor-suppressive effect in prostate cancer. Mol Endocrinol. 2014;28(12):2012-24.
10	Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
11	Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor. PLoS One. 2011;6(1):e16344.
12	Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell. 2009;36(4):667-81.
13	Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
14	Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
15	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
16	Global analysis of ZNF217 chromatin occupancy in the breast cancer cell genome reveals an association with ERalpha. BMC Genomics. 2014;15(1):520.
17	Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005;122(6):947-56.
18	FOXM1 cistrome predicts breast cancer metastatic outcome better than FOXM1 expression levels or tumor proliferation index. Breast Cancer Res Treat. 2015;154(1):23-32.
19	HSF1 functions as a key defender against palmitic acid-induced ferroptosis in cardiomyocytes. J Mol Cell Cardiol. 2021 Jan;150:65-76.
20	The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response. PLoS One. 2014;9(11):e113050.
21	ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers. OMICS. 2010;14(4):369-84.
22	p53, a novel regulator of lipid metabolism pathways. J Hepatol. 2012 Mar;56(3):656-62.
23	p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
24	ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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Detail Information of Transcriptional Regulations

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