Detail Information of Epigenetic Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0353 Transporter Info
Gene Name	SLC40A1
Transporter Name	Iron-regulated transporter 1
Gene ID	30061
UniProt ID	Q9NP59

Epigenetic Regulations of This DT (EGR)
Methylation
Prostate cancer	4 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC40A1 in prostate cancer			[ 1 ]
Location	5'UTR (cg16427983)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.09E+00	Statistic Test	p-value:1.47E-03; Z-score:4.08E+00
Methylation in Case	9.08E-01 (Median)	Methylation in Control	8.31E-01 (Median)
Studied Phenotype	Prostate cancer[ ICD-11:2C82]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC40A1 in prostate cancer			[ 1 ]
Location	TSS1500 (cg21515032)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.05E+00	Statistic Test	p-value:8.75E-03; Z-score:2.78E+00
Methylation in Case	9.08E-01 (Median)	Methylation in Control	8.65E-01 (Median)
Studied Phenotype	Prostate cancer[ ICD-11:2C82]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SLC40A1 in prostate cancer			[ 1 ]
Location	TSS1500 (cg09168997)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.15E+00	Statistic Test	p-value:1.97E-02; Z-score:1.86E+00
Methylation in Case	7.70E-01 (Median)	Methylation in Control	6.72E-01 (Median)
Studied Phenotype	Prostate cancer[ ICD-11:2C82]
Experimental Material	Patient tissue samples
Bladder cancer	5 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC40A1 in bladder cancer			[ 2 ]
Location	TSS1500 (cg04361126)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-2.75E+00	Statistic Test	p-value:9.97E-09; Z-score:-9.02E+00
Methylation in Case	2.19E-01 (Median)	Methylation in Control	6.03E-01 (Median)
Studied Phenotype	Bladder cancer[ ICD-11:2C94]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC40A1 in bladder cancer			[ 2 ]
Location	TSS1500 (cg14499385)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.71E+00	Statistic Test	p-value:6.04E-06; Z-score:-5.34E+00
Methylation in Case	1.66E-01 (Median)	Methylation in Control	2.84E-01 (Median)
Studied Phenotype	Bladder cancer[ ICD-11:2C94]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SLC40A1 in bladder cancer			[ 2 ]
Location	TSS1500 (cg14126583)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.30E+00	Statistic Test	p-value:1.01E-02; Z-score:-1.37E+00
Methylation in Case	6.34E-02 (Median)	Methylation in Control	8.24E-02 (Median)
Studied Phenotype	Bladder cancer[ ICD-11:2C94]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SLC40A1 in bladder cancer			[ 2 ]
Location	TSS1500 (cg21660960)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.19E+00	Statistic Test	p-value:1.95E-02; Z-score:1.19E+00
Methylation in Case	3.57E-02 (Median)	Methylation in Control	3.01E-02 (Median)
Studied Phenotype	Bladder cancer[ ICD-11:2C94]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon5	Methylation of SLC40A1 in bladder cancer			[ 2 ]
Location	Body (cg15599483)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.07E+00	Statistic Test	p-value:5.36E-07; Z-score:5.91E+00
Methylation in Case	8.86E-01 (Median)	Methylation in Control	8.30E-01 (Median)
Studied Phenotype	Bladder cancer[ ICD-11:2C94]
Experimental Material	Patient tissue samples
Breast cancer	4 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC40A1 in breast cancer			[ 3 ]
Location	TSS1500 (cg04361126)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.47E+00	Statistic Test	p-value:4.75E-15; Z-score:-2.60E+00
Methylation in Case	4.32E-01 (Median)	Methylation in Control	6.35E-01 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC40A1 in breast cancer			[ 3 ]
Location	TSS1500 (cg14499385)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.19E+00	Statistic Test	p-value:2.72E-11; Z-score:-1.47E+00
Methylation in Case	2.81E-01 (Median)	Methylation in Control	3.34E-01 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SLC40A1 in breast cancer			[ 3 ]
Location	TSS1500 (cg11483915)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.18E+00	Statistic Test	p-value:5.62E-04; Z-score:7.15E-01
Methylation in Case	8.80E-02 (Median)	Methylation in Control	7.46E-02 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SLC40A1 in breast cancer			[ 3 ]
Location	TSS1500 (cg21660960)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.19E+00	Statistic Test	p-value:7.35E-03; Z-score:3.76E-01
Methylation in Case	5.83E-02 (Median)	Methylation in Control	4.91E-02 (Median)
Studied Phenotype	Breast cancer[ ICD-11:2C60-2C6Z]
Experimental Material	Patient tissue samples
Renal cell carcinoma	5 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC40A1 in clear cell renal cell carcinoma			[ 4 ]
Location	TSS1500 (cg14126583)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.36E+00	Statistic Test	p-value:1.11E-04; Z-score:-1.08E+00
Methylation in Case	3.54E-02 (Median)	Methylation in Control	4.81E-02 (Median)
Studied Phenotype	Renal cell carcinoma[ ICD-11:2C90]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC40A1 in clear cell renal cell carcinoma			[ 4 ]
Location	TSS1500 (cg14499385)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.12E+00	Statistic Test	p-value:3.67E-03; Z-score:1.72E+00
Methylation in Case	4.39E-01 (Median)	Methylation in Control	3.91E-01 (Median)
Studied Phenotype	Renal cell carcinoma[ ICD-11:2C90]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SLC40A1 in clear cell renal cell carcinoma			[ 4 ]
Location	TSS1500 (cg11483915)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.33E+00	Statistic Test	p-value:3.84E-03; Z-score:6.25E-01
Methylation in Case	3.21E-02 (Median)	Methylation in Control	2.41E-02 (Median)
Studied Phenotype	Renal cell carcinoma[ ICD-11:2C90]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SLC40A1 in clear cell renal cell carcinoma			[ 4 ]
Location	TSS1500 (cg21660960)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.02E+00	Statistic Test	p-value:3.19E-02; Z-score:1.19E-01
Methylation in Case	3.47E-02 (Median)	Methylation in Control	3.41E-02 (Median)
Studied Phenotype	Renal cell carcinoma[ ICD-11:2C90]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon5	Methylation of SLC40A1 in clear cell renal cell carcinoma			[ 4 ]
Location	TSS1500 (cg09606941)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.23E+00	Statistic Test	p-value:4.76E-02; Z-score:1.40E-01
Methylation in Case	1.47E-02 (Median)	Methylation in Control	1.19E-02 (Median)
Studied Phenotype	Renal cell carcinoma[ ICD-11:2C90]
Experimental Material	Patient tissue samples
Colon cancer	4 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC40A1 in colon adenocarcinoma			[ 5 ]
Location	TSS1500 (cg24634422)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:2.29E+00	Statistic Test	p-value:5.98E-04; Z-score:5.31E+00
Methylation in Case	1.85E-01 (Median)	Methylation in Control	8.05E-02 (Median)
Studied Phenotype	Colon cancer[ ICD-11:2B90]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC40A1 in colon adenocarcinoma			[ 5 ]
Location	TSS1500 (cg15577178)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:2.44E+00	Statistic Test	p-value:6.20E-04; Z-score:5.21E+00
Methylation in Case	2.99E-01 (Median)	Methylation in Control	1.23E-01 (Median)
Studied Phenotype	Colon cancer[ ICD-11:2B90]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SLC40A1 in colon adenocarcinoma			[ 5 ]
Location	Body (cg17065011)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.13E+00	Statistic Test	p-value:3.32E-05; Z-score:-3.37E+00
Methylation in Case	5.06E-01 (Median)	Methylation in Control	5.74E-01 (Median)
Studied Phenotype	Colon cancer[ ICD-11:2B90]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SLC40A1 in colon adenocarcinoma			[ 5 ]
Location	Body (cg26877715)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.80E+00	Statistic Test	p-value:4.57E-03; Z-score:1.96E+00
Methylation in Case	1.18E-01 (Median)	Methylation in Control	6.56E-02 (Median)
Studied Phenotype	Colon cancer[ ICD-11:2B90]
Experimental Material	Patient tissue samples
Colorectal cancer	3 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC40A1 in colorectal cancer			[ 6 ]
Location	TSS1500 (cg04361126)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.41E+00	Statistic Test	p-value:2.80E-08; Z-score:-2.06E+00
Methylation in Case	4.85E-01 (Median)	Methylation in Control	6.85E-01 (Median)
Studied Phenotype	Colorectal cancer[ ICD-11:2B91]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC40A1 in colorectal cancer			[ 6 ]
Location	TSS1500 (cg14499385)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.15E+00	Statistic Test	p-value:1.66E-02; Z-score:-8.09E-01
Methylation in Case	3.37E-01 (Median)	Methylation in Control	3.86E-01 (Median)
Studied Phenotype	Colorectal cancer[ ICD-11:2B91]
Experimental Material	Patient tissue samples
Hepatocellular carcinoma	9 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC40A1 in hepatocellular carcinoma			[ 7 ]
Location	TSS1500 (cg04625905)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.52E+00	Statistic Test	p-value:3.10E-16; Z-score:-3.13E+00
Methylation in Case	4.75E-01 (Median)	Methylation in Control	7.21E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC40A1 in hepatocellular carcinoma			[ 7 ]
Location	TSS1500 (cg09606941)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.52E+00	Statistic Test	p-value:8.27E-04; Z-score:-6.22E-01
Methylation in Case	1.86E-02 (Median)	Methylation in Control	2.82E-02 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SLC40A1 in hepatocellular carcinoma			[ 7 ]
Location	TSS1500 (cg11483915)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.19E+00	Statistic Test	p-value:3.98E-03; Z-score:-6.22E-01
Methylation in Case	6.85E-02 (Median)	Methylation in Control	8.13E-02 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SLC40A1 in hepatocellular carcinoma			[ 7 ]
Location	TSS1500 (cg14126583)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.08E+00	Statistic Test	p-value:2.18E-02; Z-score:-4.10E-01
Methylation in Case	8.13E-02 (Median)	Methylation in Control	8.77E-02 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon5	Methylation of SLC40A1 in hepatocellular carcinoma			[ 7 ]
Location	TSS200 (cg13394305)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.23E+00	Statistic Test	p-value:2.45E-02; Z-score:-2.65E-01
Methylation in Case	2.01E-02 (Median)	Methylation in Control	2.47E-02 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon6	Methylation of SLC40A1 in hepatocellular carcinoma			[ 7 ]
Location	Body (cg12142062)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.65E+00	Statistic Test	p-value:3.97E-21; Z-score:-8.54E+00
Methylation in Case	4.01E-01 (Median)	Methylation in Control	6.64E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon7	Methylation of SLC40A1 in hepatocellular carcinoma			[ 7 ]
Location	Body (cg22077670)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.56E+00	Statistic Test	p-value:1.51E-14; Z-score:-2.61E+00
Methylation in Case	4.29E-01 (Median)	Methylation in Control	6.70E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon8	Methylation of SLC40A1 in hepatocellular carcinoma			[ 7 ]
Location	Body (cg08792812)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.62E+00	Statistic Test	p-value:1.90E-13; Z-score:-2.16E+00
Methylation in Case	3.08E-01 (Median)	Methylation in Control	4.98E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon9	Methylation of SLC40A1 in hepatocellular carcinoma			[ 7 ]
Location	3'UTR (cg16758084)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.37E+00	Statistic Test	p-value:6.29E-15; Z-score:-7.00E+00
Methylation in Case	6.30E-01 (Median)	Methylation in Control	8.60E-01 (Median)
Studied Phenotype	Hepatocellular carcinoma[ ICD-11:2C12.02]
Experimental Material	Patient tissue samples
HIV infection	7 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC40A1 in HIV infection			[ 8 ]
Location	TSS1500 (cg09606941)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:2.55E+00	Statistic Test	p-value:3.97E-05; Z-score:2.43E+00
Methylation in Case	4.91E-02 (Median)	Methylation in Control	1.92E-02 (Median)
Studied Phenotype	HIV infection[ ICD-11:1C62.Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC40A1 in HIV infection			[ 8 ]
Location	TSS1500 (cg11483915)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.40E+00	Statistic Test	p-value:4.96E-04; Z-score:1.50E+00
Methylation in Case	9.38E-02 (Median)	Methylation in Control	6.68E-02 (Median)
Studied Phenotype	HIV infection[ ICD-11:1C62.Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SLC40A1 in HIV infection			[ 8 ]
Location	TSS1500 (cg04361126)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.17E+00	Statistic Test	p-value:1.91E-03; Z-score:1.16E+00
Methylation in Case	3.21E-01 (Median)	Methylation in Control	2.74E-01 (Median)
Studied Phenotype	HIV infection[ ICD-11:1C62.Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SLC40A1 in HIV infection			[ 8 ]
Location	TSS1500 (cg21660960)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.76E+00	Statistic Test	p-value:5.82E-03; Z-score:1.00E+00
Methylation in Case	2.74E-02 (Median)	Methylation in Control	1.56E-02 (Median)
Studied Phenotype	HIV infection[ ICD-11:1C62.Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon5	Methylation of SLC40A1 in HIV infection			[ 8 ]
Location	TSS1500 (cg14499385)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.12E+00	Statistic Test	p-value:8.29E-03; Z-score:8.62E-01
Methylation in Case	3.05E-01 (Median)	Methylation in Control	2.73E-01 (Median)
Studied Phenotype	HIV infection[ ICD-11:1C62.Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon6	Methylation of SLC40A1 in HIV infection			[ 8 ]
Location	TSS200 (cg15893070)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.27E+00	Statistic Test	p-value:1.65E-02; Z-score:5.50E-01
Methylation in Case	2.30E-02 (Median)	Methylation in Control	1.82E-02 (Median)
Studied Phenotype	HIV infection[ ICD-11:1C62.Z]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon7	Methylation of SLC40A1 in HIV infection			[ 8 ]
Location	Body (cg15599483)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.09E+00	Statistic Test	p-value:1.83E-18; Z-score:1.92E+00
Methylation in Case	9.08E-01 (Median)	Methylation in Control	8.33E-01 (Median)
Studied Phenotype	HIV infection[ ICD-11:1C62.Z]
Experimental Material	Patient tissue samples
Lung adenocarcinoma	5 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC40A1 in lung adenocarcinoma			[ 9 ]
Location	TSS1500 (cg11483915)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.75E+00	Statistic Test	p-value:7.29E-03; Z-score:5.86E+00
Methylation in Case	1.70E-01 (Median)	Methylation in Control	9.73E-02 (Median)
Studied Phenotype	Lung adenocarcinoma[ ICD-11:2C25.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC40A1 in lung adenocarcinoma			[ 9 ]
Location	TSS1500 (cg21660960)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.45E+00	Statistic Test	p-value:1.09E-02; Z-score:1.86E+00
Methylation in Case	6.21E-02 (Median)	Methylation in Control	4.30E-02 (Median)
Studied Phenotype	Lung adenocarcinoma[ ICD-11:2C25.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SLC40A1 in lung adenocarcinoma			[ 9 ]
Location	TSS1500 (cg09606941)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:2.46E+00	Statistic Test	p-value:1.72E-02; Z-score:3.31E+00
Methylation in Case	1.17E-01 (Median)	Methylation in Control	4.75E-02 (Median)
Studied Phenotype	Lung adenocarcinoma[ ICD-11:2C25.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SLC40A1 in lung adenocarcinoma			[ 9 ]
Location	TSS200 (cg15893070)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.37E+00	Statistic Test	p-value:1.92E-03; Z-score:2.21E+00
Methylation in Case	7.10E-02 (Median)	Methylation in Control	5.19E-02 (Median)
Studied Phenotype	Lung adenocarcinoma[ ICD-11:2C25.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon5	Methylation of SLC40A1 in lung adenocarcinoma			[ 9 ]
Location	TSS200 (cg13394305)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:3.35E+00	Statistic Test	p-value:1.24E-02; Z-score:1.13E+01
Methylation in Case	1.10E-01 (Median)	Methylation in Control	3.27E-02 (Median)
Studied Phenotype	Lung adenocarcinoma[ ICD-11:2C25.0]
Experimental Material	Patient tissue samples
Panic disorder	3 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC40A1 in panic disorder			[ 10 ]
Location	TSS1500 (cg21660960)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-9.85E-01	Statistic Test	p-value:1.57E-02; Z-score:-3.35E-01
Methylation in Case	-4.61E+00 (Median)	Methylation in Control	-4.55E+00 (Median)
Studied Phenotype	Panic disorder[ ICD-11:6B01]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC40A1 in panic disorder			[ 10 ]
Location	TSS1500 (cg09606941)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-9.84E-01	Statistic Test	p-value:2.34E-02; Z-score:-1.17E-01
Methylation in Case	-6.39E+00 (Median)	Methylation in Control	-6.29E+00 (Median)
Studied Phenotype	Panic disorder[ ICD-11:6B01]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SLC40A1 in panic disorder			[ 10 ]
Location	1stExon (cg10752008)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-9.50E-01	Statistic Test	p-value:3.41E-02; Z-score:-4.40E-01
Methylation in Case	-3.47E+00 (Median)	Methylation in Control	-3.30E+00 (Median)
Studied Phenotype	Panic disorder[ ICD-11:6B01]
Experimental Material	Patient tissue samples
Papillary thyroid cancer	5 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC40A1 in papillary thyroid cancer			[ 11 ]
Location	TSS1500 (cg14499385)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.18E+00	Statistic Test	p-value:5.08E-06; Z-score:1.38E+00
Methylation in Case	3.56E-01 (Median)	Methylation in Control	3.02E-01 (Median)
Studied Phenotype	Papillary thyroid cancer[ ICD-11:2D10.1]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC40A1 in papillary thyroid cancer			[ 11 ]
Location	TSS1500 (cg04361126)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.10E+00	Statistic Test	p-value:5.82E-04; Z-score:1.08E+00
Methylation in Case	7.15E-01 (Median)	Methylation in Control	6.49E-01 (Median)
Studied Phenotype	Papillary thyroid cancer[ ICD-11:2D10.1]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon3	Methylation of SLC40A1 in papillary thyroid cancer			[ 11 ]
Location	TSS1500 (cg21660960)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.07E+00	Statistic Test	p-value:2.37E-02; Z-score:5.53E-01
Methylation in Case	9.23E-02 (Median)	Methylation in Control	8.61E-02 (Median)
Studied Phenotype	Papillary thyroid cancer[ ICD-11:2D10.1]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon4	Methylation of SLC40A1 in papillary thyroid cancer			[ 11 ]
Location	TSS1500 (cg14126583)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.02E+00	Statistic Test	p-value:4.15E-02; Z-score:-1.03E-01
Methylation in Case	1.12E-01 (Median)	Methylation in Control	1.14E-01 (Median)
Studied Phenotype	Papillary thyroid cancer[ ICD-11:2D10.1]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon5	Methylation of SLC40A1 in papillary thyroid cancer			[ 11 ]
Location	1stExon (cg10752008)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.07E+00	Statistic Test	p-value:3.83E-02; Z-score:4.61E-01
Methylation in Case	8.99E-02 (Median)	Methylation in Control	8.43E-02 (Median)
Studied Phenotype	Papillary thyroid cancer[ ICD-11:2D10.1]
Experimental Material	Patient tissue samples
Systemic lupus erythematosus	2 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC40A1 in systemic lupus erythematosus			[ 12 ]
Location	TSS1500 (cg14126583)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.02E+00	Statistic Test	p-value:1.06E-02; Z-score:-4.56E-02
Methylation in Case	1.01E-01 (Median)	Methylation in Control	1.03E-01 (Median)
Studied Phenotype	Systemic lupus erythematosus[ ICD-11:4A40.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC40A1 in systemic lupus erythematosus			[ 12 ]
Location	TSS200 (cg13394305)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.05E+00	Statistic Test	p-value:9.91E-03; Z-score:-2.33E-02
Methylation in Case	1.34E-02 (Median)	Methylation in Control	1.41E-02 (Median)
Studied Phenotype	Systemic lupus erythematosus[ ICD-11:4A40.0]
Experimental Material	Patient tissue samples
Atypical teratoid rhabdoid tumor	2 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC40A1 in atypical teratoid rhabdoid tumor			[ 13 ]
Location	1stExon (cg10752008)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:1.73E+00	Statistic Test	p-value:2.01E-19; Z-score:2.98E+00
Methylation in Case	6.22E-01 (Median)	Methylation in Control	3.60E-01 (Median)
Studied Phenotype	Atypical teratoid rhabdoid tumor[ ICD-11:2A00.1Y]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC40A1 in atypical teratoid rhabdoid tumor			[ 13 ]
Location	Body (cg01158447)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.20E+00	Statistic Test	p-value:4.87E-05; Z-score:-6.24E-01
Methylation in Case	3.70E-01 (Median)	Methylation in Control	4.46E-01 (Median)
Studied Phenotype	Atypical teratoid rhabdoid tumor[ ICD-11:2A00.1Y]
Experimental Material	Patient tissue samples
Depression	1 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC40A1 in depression			[ 14 ]
Location	Body (cg15599483)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.03E+00	Statistic Test	p-value:4.60E-02; Z-score:-5.41E-01
Methylation in Case	6.73E-01 (Median)	Methylation in Control	6.96E-01 (Median)
Studied Phenotype	Depression[ ICD-11:6A8Z]
Experimental Material	Patient tissue samples
Pancretic ductal adenocarcinoma	2 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Methylation of SLC40A1 in pancretic ductal adenocarcinoma			[ 15 ]
Location	Body (cg18781372)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.01E+00	Statistic Test	p-value:1.95E-05; Z-score:-2.89E-01
Methylation in Case	8.45E-01 (Median)	Methylation in Control	8.54E-01 (Median)
Studied Phenotype	Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]
Experimental Material	Patient tissue samples
Epigenetic Phenomenon2	Methylation of SLC40A1 in pancretic ductal adenocarcinoma			[ 15 ]
Location	Body (cg19717347)
Epigenetic Type	Methylation	Experiment Method	Infinium HumanMethylation450 BeadChip
Methylation Fold Change	Fold Change:-1.04E+00	Statistic Test	p-value:1.37E-03; Z-score:-6.39E-01
Methylation in Case	8.49E-01 (Median)	Methylation in Control	8.79E-01 (Median)
Studied Phenotype	Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]
Experimental Material	Patient tissue samples
Oligodendroglial tumour	1 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Moderate hypermethylation of SLC40A1 in oligodendroglial tumour than that in healthy individual
Studied Phenotype	Oligodendroglial tumour [ICD-11:2A00.Y1]
The Methylation Level of Disease Section Compare with the Healthy Individual	p-value:2.27E-09; Fold-change:0.264081071; Z-score:18.60272558
DT methylation level in the diseased tissue of patients DT methylation level in the normal tissue of healthy individuals
			Please Click the above Thumbnail to View/Download the Methylation Barchart for All Samples
Download DT methylation data of patients in the disease section of the tissue Download DT methylation data in the tissue of healthy individual
Lymphoma	1 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Significant hypermethylation of SLC40A1 in lymphoma than that in healthy individual
Studied Phenotype	Lymphoma [ICD-11:2B30]
The Methylation Level of Disease Section Compare with the Healthy Individual	p-value:2.82E-15; Fold-change:0.46271086; Z-score:5.947384832
DT methylation level in the diseased tissue of patients DT methylation level in the normal tissue of healthy individuals
			Please Click the above Thumbnail to View/Download the Methylation Barchart for All Samples
Download DT methylation data of patients in the disease section of the tissue Download DT methylation data in the tissue of healthy individual
Oligodendroglioma	1 Epigenetic Phenomena Related to This Phenotype		Click to Show/Hide the Full List
Epigenetic Phenomenon1	Significant hypermethylation of SLC40A1 in oligodendroglioma than that in healthy individual
Studied Phenotype	Oligodendroglioma [ICD-11:2A00.0Y]
The Methylation Level of Disease Section Compare with the Healthy Individual	p-value:6.32E-41; Fold-change:0.55188235; Z-score:3.644433598
DT methylation level in the diseased tissue of patients DT methylation level in the normal tissue of healthy individuals
			Please Click the above Thumbnail to View/Download the Methylation Barchart for All Samples
Download DT methylation data of patients in the disease section of the tissue Download DT methylation data in the tissue of healthy individual

References
1	Reducing the risk of false discovery enabling identification of biologically significant genome-wide methylation status using the HumanMethylation450 array. BMC Genomics. 2014 Jan 22;15:51.
2	DNA Methylation Dynamics in Urological Tumors.
3	Genome-wide Scan for Methylation Profiles in Breast Cancer
4	A CpG-methylation-based assay to predict survival in clear cell renal cell carcinoma. Nat Commun. 2015 Oct 30;6:8699.
5	Genome-scale analysis of DNA methylation in colorectal cancer using Infinium HumanMethylation450 BeadChips. Epigenetics. 2013 Sep;8(9):921-34.
6	Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer. Gastroenterology. 2014 Aug;147(2):418-29.e8.
7	Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips. Epigenetics. 2013 Jan;8(1):34-43.
8	HIV-1 Infection Accelerates Age According to the Epigenetic Clock. J Infect Dis. 2015 Nov 15;212(10):1563-73.
9	DNA methylation analysis of lung adenocarcinoma and adjacent non-tumor tissues
10	DNA Methylation signatures in panic disorder. Transl Psychiatry. 2017 Dec 18;7(12):1287.
11	Prognostic Classifier Based on Genome-Wide DNA Methylation Profiling in Well-Differentiated Thyroid Tumors. J Clin Endocrinol Metab. 2017 Nov 1;102(11):4089-4099.
12	Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations. PLoS Genet. 2013;9(8):e1003678.
13	Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes. Cancer Cell. 2016 Mar 14;29(3):379-393.
14	DNA methylation and inflammation marker profiles associated with a history of depression. Hum Mol Genet. 2018 Aug 15;27(16):2840-2850.
15	Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling. Int J Cancer. 2014 Sep 1;135(5):1110-8.

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