Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0353 Transporter Info
Gene Name	SLC40A1
Transporter Name	Iron-regulated transporter 1
Gene ID	30061
UniProt ID	Q9NP59

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Copper results in increased expression of SLC40A1 mRNA		[55]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Copper results in increased expression of SLC40A1 protein		[55]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin results in increased expression of SLC40A1 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Cisplatin co-treated with Panobinostat affects the expression of SLC40A1 mRNA		[53]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC40A1 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	ferrostatin-1 affects the reaction Valproic Acid results in decreased expression of SLC40A1 protein		[62]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC40A1 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Valproic Acid results in decreased expression of SLC40A1 protein		[62]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction Ethanol co-treated with Benzo(a)pyrene which results in increased expression of SLC40A1 mRNA		[47]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC40A1 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction Ethanol co-treated with Benzo(a)pyrene which results in increased expression of SLC40A1 mRNA		[47]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in decreased methylation of SLC40A1 promoter		[48]
Regulation Mechanism			Transcription Factor Info
1,3-dichloro-2-propanol	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	1,3-dichloro-2-propanol results in decreased expression of SLC40A1 protein		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Dimethyl Fumarate inhibits the reaction 1,3-dichloro-2-propanol results in decreased expression of SLC40A1 protein		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Thiazoles binds to indoline promotes the reaction 1,3-dichloro-2-propanol results in decreased expression of SLC40A1 protein		[35]
Regulation Mechanism			Transcription Factor Info
1-Methyl-3-isobutylxanthine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin results in increased expression of SLC40A1 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
2,2',4,4'-tetrabromodiphenyl ether	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of SLC40A1 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
2,4,5,2',4',5'-hexachlorobiphenyl	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of SLC40A1 protein		[38]
Regulation Mechanism			Transcription Factor Info
3,4,5,3',4'-pentachlorobiphenyl	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SLC40A1 protein		[38]
Regulation Mechanism			Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	6 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC40A1 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC40A1 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC40A1 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC40A1 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC40A1 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC40A1 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SLC40A1 mRNA		[40]
Regulation Mechanism			Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of SLC40A1 mRNA		[41]
Regulation Mechanism			Transcription Factor Info
Asbestos, Crocidolite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Asbestos, Crocidolite results in decreased expression of SLC40A1 mRNA		[46]
Regulation Mechanism			Transcription Factor Info
bisphenol A	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A affects the expression of SLC40A1 mRNA		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	bisphenol A results in increased expression of SLC40A1 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
Cadmium Chloride	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in decreased expression of SLC40A1 mRNA		[49]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Cadmium Chloride results in increased abundance of Cadmium which results in decreased expression of SLC40A1 protein		[49]
Regulation Mechanism			Transcription Factor Info
Catechin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Catechin co-treated with Grape Seed Proanthocyanidins results in increased expression of SLC40A1 mRNA		[50]
Regulation Mechanism			Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC40A1 gene		[51]
Regulation Mechanism			Transcription Factor Info
Cisplatin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cisplatin co-treated with jinfukang results in increased expression of SLC40A1 mRNA		[52]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Cisplatin co-treated with Panobinostat affects the expression of SLC40A1 mRNA		[53]
Regulation Mechanism			Transcription Factor Info
Cobalt	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cobalt inhibits the reaction SLC40A1 protein results in increased export of Manganese		[54]
Regulation Mechanism			Transcription Factor Info
Diazinon	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Diazinon results in increased methylation of SLC40A1 gene		[56]
Regulation Mechanism			Transcription Factor Info
dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	dicrotophos results in decreased expression of SLC40A1 mRNA		[26]
Regulation Mechanism			Transcription Factor Info
diethyl maleate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	diethyl maleate inhibits the reaction Lipopolysaccharides results in decreased expression of SLC40A1 mRNA		[57]
Regulation Mechanism			Transcription Factor Info
Dimethyl Fumarate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dimethyl Fumarate inhibits the reaction 1,3-dichloro-2-propanol results in decreased expression of SLC40A1 protein		[35]
Regulation Mechanism			Transcription Factor Info
di-n-butylphosphoric acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	di-n-butylphosphoric acid affects the expression of SLC40A1 mRNA		[58]
Regulation Mechanism			Transcription Factor Info
dorsomorphin	6 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC40A1 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC40A1 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC40A1 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC40A1 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC40A1 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC40A1 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
epigallocatechin gallate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	potassium chromate(VI) co-treated with epigallocatechin gallate results in decreased expression of SLC40A1 mRNA		[59]
Regulation Mechanism			Transcription Factor Info
erastin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	erastin results in increased expression of SLC40A1 protein		[29]
Regulation Mechanism			Transcription Factor Info
Estradiol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol co-treated with Progesterone results in decreased expression of SLC40A1 mRNA		[60]
Regulation Mechanism			Transcription Factor Info
ferric nitrilotriacetate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ferric nitrilotriacetate results in decreased expression of SLC40A1 mRNA		[61]
Regulation Mechanism			Transcription Factor Info
ferrostatin-1	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ferrostatin-1 affects the reaction Valproic Acid results in decreased expression of SLC40A1 protein		[62]
Regulation Mechanism			Transcription Factor Info
ferrous chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ferrous chloride results in decreased expression of SLC40A1 mRNA		[63]
Regulation Mechanism			Transcription Factor Info
gallium nitrate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	gallium nitrate results in decreased expression of SLC40A1 mRNA		[3]
Regulation Mechanism			Transcription Factor Info
Glucose	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Glucose results in increased expression of SLC40A1 protein		[64]
Regulation Mechanism			Transcription Factor Info
indoline	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thiazoles binds to indoline promotes the reaction 1,3-dichloro-2-propanol results in decreased expression of SLC40A1 protein		[35]
Regulation Mechanism			Transcription Factor Info
Indomethacin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin results in increased expression of SLC40A1 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
Manganese	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cobalt inhibits the reaction SLC40A1 protein results in increased export of Manganese		[54]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Iron inhibits the reaction SLC40A1 protein results in increased export of Manganese		[54]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Nickel inhibits the reaction SLC40A1 protein results in increased export of Manganese		[54]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	SLC40A1 protein results in increased export of Manganese		[54]
Regulation Mechanism			Transcription Factor Info
mercuric bromide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	mercuric bromide results in increased expression of SLC40A1 mRNA		[13]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC40A1 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
Methapyrilene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methapyrilene results in increased expression of SLC40A1 mRNA		[67]
Regulation Mechanism			Transcription Factor Info
methylmercuric chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	methylmercuric chloride results in decreased expression of SLC40A1 mRNA		[68]
Regulation Mechanism			Transcription Factor Info
nickel sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	nickel sulfate results in increased expression of SLC40A1 mRNA		[70]
Regulation Mechanism			Transcription Factor Info
N,N'-Bis(2-mercaptoethyl)isophthalamide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Lead co-treated with N,N'-Bis(2-mercaptoethyl)isophthalamide results in increased expression of SLC40A1 protein		[66]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	N,N'-Bis(2-mercaptoethyl)isophthalamide results in increased expression of SLC40A1 protein		[66]
Regulation Mechanism			Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in decreased expression of SLC40A1 mRNA		[71]
Regulation Mechanism			Transcription Factor Info
p-Chloromercuribenzoic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC40A1 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	p-Chloromercuribenzoic Acid results in increased expression of SLC40A1 mRNA		[13]
Regulation Mechanism			Transcription Factor Info
pentabromodiphenyl ether	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	pentabromodiphenyl ether analog results in decreased expression of SLC40A1 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
potassium chromate(VI)	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	potassium chromate(VI) co-treated with epigallocatechin gallate results in decreased expression of SLC40A1 mRNA		[59]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	potassium chromate(VI) results in decreased expression of SLC40A1 mRNA		[59]
Regulation Mechanism			Transcription Factor Info
Progesterone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol co-treated with Progesterone results in decreased expression of SLC40A1 mRNA		[60]
Regulation Mechanism			Transcription Factor Info
S-(1,2-dichlorovinyl)cysteine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides which results in increased expression of SLC40A1 mRNA		[74]
Regulation Mechanism			Transcription Factor Info
sclareol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sclareol results in decreased expression of SLC40A1 protein		[75]
Regulation Mechanism			Transcription Factor Info
Silicon Dioxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog results in decreased expression of SLC40A1 mRNA		[76]
Regulation Mechanism			Transcription Factor Info
Silver	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Silver results in increased expression of SLC40A1 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic which results in increased expression of SLC40A1 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased expression of SLC40A1 mRNA		[70]
Regulation Mechanism			Transcription Factor Info
Tetrachlorodibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tetrachlorodibenzodioxin affects the expression of SLC40A1 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
Thiazoles	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thiazoles binds to indoline promotes the reaction 1,3-dichloro-2-propanol results in decreased expression of SLC40A1 protein		[35]
Regulation Mechanism			Transcription Factor Info
toosendanin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	toosendanin results in decreased expression of SLC40A1 mRNA		[77]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	toosendanin results in decreased expression of SLC40A1 protein		[77]
Regulation Mechanism			Transcription Factor Info
trichostatin A	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC40A1 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	trichostatin A results in increased expression of SLC40A1 mRNA		[78]
Regulation Mechanism			Transcription Factor Info
Vanadates	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vanadates results in decreased expression of SLC40A1 mRNA		[70]
Regulation Mechanism			Transcription Factor Info
Dietary Constituent
Iron	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CP protein results in increased oxidation of Iron which results in increased stability of SLC40A1 protein		[65]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Iron affects the reaction HAMP protein results in increased uptake of SLC40A1 protein		[65]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Iron inhibits the reaction SLC40A1 protein results in increased export of Manganese		[54]
Regulation Mechanism			Transcription Factor Info
Herbicide
Paraquat	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NFE2L2 protein promotes the reaction Paraquat results in increased expression of SLC40A1 protein		[72]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Paraquat results in increased expression of SLC40A1 protein		[72]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Folic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Folic Acid affects the expression of SLC40A1		[1]
Copper	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Copper inhibits the expression of SLC40A1		[2]
Gallium nitrate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Gallium nitrate inhibits the expression of SLC40A1		[3]
Arsenic Trioxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic Trioxide increases the expression of SLC40A1		[4]
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate increases the expression of SLC40A1		[5]
Ethinyl Estradiol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ethinyl Estradiol affects the expression of SLC40A1		[6]
Dasatinib	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dasatinib increases the expression of SLC40A1		[7]
Cytarabine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cytarabine inhibits the expression of SLC40A1		[8]
Azathioprine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Azathioprine increases the expression of SLC40A1		[9]
Zidovudine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zidovudine increases the expression of SLC40A1		[10]
Zoledronic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zoledronic Acid increases the expression of SLC40A1		[11]
Dexamethasone	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dexamethasone increases the expression of SLC40A1		[12]
Panobinostat	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Panobinostat increases the expression of SLC40A1		[13]
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Doxorubicin increases the expression of SLC40A1		[14]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of SLC40A1		[15]
Acetaminophen	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of SLC40A1		[16]
DT Modulation2	Acetaminophen results in increased expression of SLC40A1 mRNA		[42]
Regulation Mechanism			Transcription Factor Info
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tretinoin increases the expression of SLC40A1		[17]
Valproic Acid	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of SLC40A1		[18]
Drug in Phase 2 Trial
Ethanol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ethanol increases the expression of SLC40A1		[22]
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol A increases the expression of SLC40A1		[27]
Drug in Phase 1 Trial
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the expression of SLC40A1		[31]
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite increases the expression of SLC40A1		[32]
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Trichostatin A increases the expression of SLC40A1		[13]
LY2928057	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	LY2928057 modulates the activity of SLC40A1		[34]
Investigative Drug
Phenylmercuric Acetate	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phenylmercuric Acetate increases the expression of SLC40A1		[13]
Patented Pharmaceutical Agent
Erastin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Erastin increases the expression of SLC40A1		[29]
Natural Product
Dietary Carbohydrates	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dietary Carbohydrates increases the expression of SLC40A1		[19]
Particulate Matter	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Particulate Matter inhibits the expression of SLC40A1		[24]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the expression of SLC40A1		[33]
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin affects the expression of SLC40A1		[21]
Lead	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Lead co-treated with N,N'-Bis(2-mercaptoethyl)isophthalamide results in increased expression of SLC40A1 protein		[66]
Regulation Mechanism			Transcription Factor Info
Mycotoxins
Aflatoxin B1	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 increases the expression of SLC40A1		[20]
DT Modulation2	Aflatoxin B1 affects the expression of SLC40A1 protein		[43]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Aflatoxin B1 results in decreased methylation of SLC40A1 gene		[44]
Regulation Mechanism			Transcription Factor Info
Acute Toxic Substance
Chlorpyrifos	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Chlorpyrifos increases the expression of SLC40A1		[23]
Carcinogen
Benzo(a)pyrene	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene increases the expression of SLC40A1		[30]
Arsenic	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic which results in increased expression of SLC40A1 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
Cadmium	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in decreased expression of SLC40A1 mRNA		[49]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Cadmium Chloride results in increased abundance of Cadmium which results in decreased expression of SLC40A1 protein		[49]
Regulation Mechanism			Transcription Factor Info
Nickel	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nickel inhibits the reaction SLC40A1 protein results in increased export of Manganese		[54]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Nickel results in decreased expression of SLC40A1 mRNA		[69]
Regulation Mechanism			Transcription Factor Info
Pesticide/Insecticide
Dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dicrotophos inhibits the expression of SLC40A1		[26]
Health and Environmental Toxicant
Diethylhexyl Phthalate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Diethylhexyl Phthalate increases the expression of SLC40A1		[28]
Nanoparticle
Silver nanoparticle	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Silver nanoparticle increases the expression of SLC40A1		[25]
perfluoro-n-nonanoic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluoro-n-nonanoic acid results in decreased expression of SLC40A1 mRNA		[73]
Regulation Mechanism			Transcription Factor Info

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