Detail Information of DT Wildtype Structure
| General Information of Drug Transporter (DT) | ||||||
|---|---|---|---|---|---|---|
| DT ID | DTD0353 Transporter Info | |||||
| Gene Name | SLC40A1 | |||||
| Transporter Name | Iron-regulated transporter 1 | |||||
| Gene ID | ||||||
| UniProt ID | ||||||
| Experimental Structures of This DT | ||||||
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| Detail Information of Experimental Structure | ||||||
| PDB ID | 6WBV | [ 1 ] | ||||
| Method | EM | |||||
| Expression System | Spodoptera frugiperda | |||||
| Resolution | 2.5 Å | |||||
| Corresponding chain | A | |||||
| Sequence length | 1-571 | |||||
| Mutation | No | |||||
| Publication Year | 2020 | |||||
| AlphaFold Protein Structure Database | ||||||
| Experimental Structures of This DT | ||||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref | |
| 6W4S | EM | 3.2 Å | Spodoptera frugiperda | [1] | ||
| Structure | ||||||
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| Corresponding chain | F | |||||
| Sequence Length | 1-571 | Mutation | No | |||
| 8BZY | EM | 3.24 Å | Escherichia coli,Homo sapiens | [2] | ||
| Structure | ||||||
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| Corresponding chain | A | |||||
| Sequence Length | 580 | Mutation | No | |||
| 8C02 | EM | 4.09 Å | Escherichia coli,Homo sapiens | [2] | ||
| Structure | ||||||
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| Corresponding chain | A | |||||
| Sequence Length | 580 | Mutation | No | |||
| 8C03 | EM | 3.89 Å | Homo sapiens | [2] | ||
| Structure | ||||||
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| Corresponding chain | A | |||||
| Sequence Length | 580 | Mutation | No | |||
| 8DL6 | EM | 3 Å | Spodoptera frugiperda | [3] | ||
| Structure | ||||||
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| Corresponding chain | A | |||||
| Sequence Length | 577 | Mutation | No | |||
| 8DL7 | EM | 2.7 Å | Spodoptera frugiperda | [4] | ||
| Structure | ||||||
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| Corresponding chain | A | |||||
| Sequence Length | 577 | Mutation | No | |||
| 8DL8 | EM | 3 Å | Spodoptera frugiperda | [4] | ||
| Structure | ||||||
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| Corresponding chain | A | |||||
| Sequence Length | 577 | Mutation | No | |||
| References | ||||||
| 1 | Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms. Nature. 2020 Oct;586(7831):807-811. | |||||
| 2 | Structures of ferroportin in complex with its specific inhibitor vamifeport. Elife. 2023;12. | |||||
| 3 | Mechanism of Ca(2+) transport by ferroportin. Elife. 2023;12. | |||||
| 4 | Structural basis of ferroportin inhibition by minihepcidin PR73. PLoS Biol. 2023;21(1):e3001936. | |||||
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