Microbe Species Information

General Information of This Microbe species
Species ID	MIC00123
Species Name	Brucella abortus
Taxonomy ID	235
Lineage	Kingdom:Bacteria Phylum:Pseudomonadota Class:Alphaproteobacteria Order:Hyphomicrobiales Family:Brucellaceae Genus: Brucella Species: Brucella abortus

Drug Transporter(s) Regulated by This Microbe species
Class1: Microbiota direct bioaccumulation of drugs
FLVCR1	Transporter Info	Health [ICD11: N.A]	[1], [2], [3], [4]
SLC11A1	Transporter Info	Health [ICD11: N.A]	[5], [6], [7], [8]
SLC48A1	Transporter Info	Health [ICD11: N.A]	[1], [2], [3], [4]
SLC49A2	Transporter Info	Health [ICD11: N.A]	[1], [2], [3], [4]
ZIP1	Transporter Info	Health [ICD11: N.A]	[9], [10], [11]
ZIP10	Transporter Info	Health [ICD11: N.A]	[9], [10], [11]
ZIP11	Transporter Info	Health [ICD11: N.A]	[9], [10], [11]
ZIP12	Transporter Info	Health [ICD11: N.A]	[9], [10], [11]
ZIP13	Transporter Info	Health [ICD11: N.A]	[9], [10], [11]
ZIP14	Transporter Info	Health [ICD11: N.A]	[9], [10], [11]
ZIP2	Transporter Info	Health [ICD11: N.A]	[9], [10], [11]
ZIP3	Transporter Info	Health [ICD11: N.A]	[9], [10], [11]
ZIP4	Transporter Info	Health [ICD11: N.A]	[9], [10], [11]
ZIP5	Transporter Info	Health [ICD11: N.A]	[9], [10], [11]
ZIP6	Transporter Info	Health [ICD11: N.A]	[9], [10], [11]
ZIP7	Transporter Info	Health [ICD11: N.A]	[9], [10], [11]
ZIP8	Transporter Info	Health [ICD11: N.A]	[9], [10], [11]
ZIP9	Transporter Info	Health [ICD11: N.A]	[9], [10], [11]

References
1	Sequestration and scavenging of iron in infection. Infect Immun. 2013 Oct;81(10):3503-14.
2	Brucella abortus requires the heme transporter BhuA for maintenance of chronic infection in BALB/c mice. Infect Immun. 2007 Nov;75(11):5248-54.
3	Heme Mobilization in Animals: A Metallolipid's Journey. Acc Chem Res. 2016 Jun 21;49(6):1104-10.
4	Handling heme: The mechanisms underlying the movement of heme within and between cells. Free Radic Biol Med. 2019 Mar;133:88-100.
5	Manganese homeostasis and utilization in pathogenic bacteria. Mol Microbiol. 2015 Jul;97(2):216-28.
6	The manganese transporter MntH is a critical virulence determinant for Brucella abortus 2308 in experimentally infected mice. Infect Immun. 2009 Aug;77(8):3466-74.
7	Human iron transporters. Genes Nutr. 2011 Feb;6(1):45-54.
8	Iron transport machinery of human cells: players and their interactions. Curr Top Membr. 2012;69:67-93.
9	Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesis. Front Cell Infect Microbiol. 2014 Jan 24;4:2.
10	Zinc uptake system (znuA locus) of Brucella abortus is essential for intracellular survival and virulence in mice. J Vet Med Sci. 2004 Sep;66(9):1059-63.
11	Transition metals and host-microbe interactions in the inflamed intestine. Biometals. 2019 Jun;32(3):369-384.

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