Detail Information of Microbiota Influence

General Information of Drug Transporter (DT)
DT ID DTD0080 Transporter Info
Gene Name SLC11A1
Transporter Name Natural resistance-associated macrophage protein 1
Gene ID
6556
UniProt ID
P49279
Microbiota Influence of This DT (MBI)

Bacteria: Actinomycetota

   Genus: Mycobacterium

     Mycobacterium avium 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Sequestration of human SLC11A1 substrates/drugs in the health condition [1], [2], [3], [4]

Regulating Factor
Mycobactin

Studied Tissue

 Blood

In Vivo Model

 C57BL/6 mice

Detailed Description

 The compound mycobactin secreted by Mycobacterium avium 101 has been reported to sequester the substrate/drug of SLC11A1, which may affects its substrate/drug distribution in the body.

     Mycobacterium leprae 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC11A1 substrates/drugs in the health condition [3], [4], [5], [6], [7]

Regulating Factor
mntH

Detailed Description

 The protein mnth of Mycobacterium leprae has been reported to transport similar substrates/drugs of SLC11A1, which affects the distribution of its substrate/drug in vivo.

     Mycobacterium tuberculosis 

Microbe Info

Click to Show/Hide the Full List 5 Microbe Influence Related to This Species      

       Microbe Influence1

 Sequestration of human SLC11A1 substrates/drugs in the health condition [1], [2], [3], [4]

Regulating Factor
Mycobactin

Studied Tissue

 Blood

In Vivo Model

 C57BL/6 mice

Detailed Description

 The compound Mycobactin Secreted by Mycobacterium tuberculosis H37Rv has been reported to sequester the substrate/drug of SLC11A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence2

 Sequestration of human SLC11A1 substrates/drugs in the health condition [8], [9], [3], [4]

Regulating Factor
Mycobactin

Detailed Description

 The compound mycobactin secreted by Mycobacterium tuberculosis has been reported to sequester the substrate/drug of SLC11A1, which may affects its substrate/drug distribution in the body.

       Microbe Influence3

 Co-transport of human SLC11A1 substrates/drugs in the health condition [3], [4], [5], [6], [10]

Regulating Factor
mntH

Detailed Description

 The protein mntH of Mycobacterium tuberculosis H37Rv has been reported to transport similar substrates/drugs of SLC11A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence4

 Co-transport of human SLC11A1 substrates/drugs in the health condition [3], [4], [5], [6], [10]

Regulating Factor
mntH

Detailed Description

 The protein mntH of Mycobacterium tuberculosis H37Rv has been reported to transport similar substrates/drugs of SLC11A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence5

 Co-transport of human SLC11A1 substrates/drugs in the health condition [3], [4], [5], [6], [10]

Regulating Factor
mntH

Detailed Description

 The protein mntH of Mycobacterium tuberculosis H37Rv has been reported to transport similar substrates/drugs of SLC11A1, which affects the distribution of its substrate/drug in vivo.

   Genus: Mycolicibacterium

     Mycolicibacterium smegmatis 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Sequestration of human SLC11A1 substrates/drugs in the health condition [1], [2], [3], [4]

Regulating Factor
Mycobactin

Studied Tissue

 Blood

In Vivo Model

 C57BL/6 mice

Detailed Description

 The compound Mycobactin Secreted by Mycolicibacterium smegmatis MC2 155 has been reported to sequester the substrate/drug of SLC11A1, which may affects its substrate/drug distribution in the body.

Bacteria: Bacillota

   Genus: Bacillus

     Bacillus subtilis 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC11A1 substrates/drugs in the health condition [3], [4], [5], [6], [11]

Regulating Factor
mntH

Detailed Description

 The protein mntH of Bacillus subtilis CU1065 has been reported to transport similar substrates/drugs of SLC11A1, which affects the distribution of its substrate/drug in vivo.

   Genus: Clostridium

     Clostridium acetobutylicum 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC11A1 substrates/drugs in the health condition [12], [3], [4]

Regulating Factor
nrmT

Detailed Description

 The protein nrmT of Clostridium acetobutylicum ATCC 824 has been reported to transport similar substrates/drugs of SLC11A1, which affects the distribution of its substrate/drug in vivo.

   Genus: Staphylococcus

     Staphylococcus aureus 

Microbe Info

Click to Show/Hide the Full List 2 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC11A1 substrates/drugs in the health condition [5], [13], [3], [4]

Regulating Factor
mntH

Studied Tissue

 Liver

In Vivo Model

 C57BL/6 mice

Detailed Description

 The protein mntH of Staphylococcus aureus subsp. aureus str. Newman has been reported to transport similar substrates/drugs of SLC11A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence2

 Co-transport of human SLC11A1 substrates/drugs in the health condition [3], [4], [5], [6], [14]

Regulating Factor
mntH

Detailed Description

 The protein mntH of Staphylococcus aureus subsp. aureus NCTC 8325 has been reported to transport similar substrates/drugs of SLC11A1, which affects the distribution of its substrate/drug in vivo.

Bacteria: Pseudomonadota

   Genus: Bradyrhizobium

     Bradyrhizobium diazoefficiens 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC11A1 substrates/drugs in the health condition [3], [4], [5], [15], [16]

Regulating Factor
mntH

Detailed Description

 The protein mntH of Bradyrhizobium diazoefficiens has been reported to transport similar substrates/drugs of SLC11A1, which affects the distribution of its substrate/drug in vivo.

   Genus: Brucella

     Brucella abortus 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC11A1 substrates/drugs in the health condition [5], [17], [3], [4]

Regulating Factor
mntH

Studied Tissue

 Blood

In Vivo Model

 C57BL/6 mice

Detailed Description

 The protein mnth of Brucella abortus 2308 has been reported to transport similar substrates/drugs of SLC11A1, which affects the distribution of its substrate/drug in vivo.

   Genus: Escherichia

     Escherichia coli 

Microbe Info

Click to Show/Hide the Full List 3 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC11A1 substrates/drugs in the health condition [3], [4], [5], [18], [19]

Regulating Factor
mntH

Detailed Description

 The protein mntH of Escherichia coli EMG2 has been reported to transport similar substrates/drugs of SLC11A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence2

 Co-transport of human SLC11A1 substrates/drugs in the health condition [3], [4], [5], [18], [19]

Regulating Factor
mntH

Detailed Description

 The protein mntH of Escherichia coli EMG2 has been reported to transport similar substrates/drugs of SLC11A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence3

 Co-transport of human SLC11A1 substrates/drugs in the health condition [3], [4], [5], [6], [18]

Regulating Factor
mntH

Detailed Description

 The protein mntH of Escherichia coli MM1925 has been reported to transport similar substrates/drugs of SLC11A1, which affects the distribution of its substrate/drug in vivo.

   Genus: Salmonella

     Salmonella enterica 

Microbe Info

Click to Show/Hide the Full List 3 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC11A1 substrates/drugs in the health condition [5], [13], [3], [4]

Regulating Factor
mntH

Studied Tissue

 Liver

In Vivo Model

 C57BL/6 mice

Detailed Description

 The protein mntH of Salmonella enterica subsp. enterica serovar Typhimurium IR715 has been reported to transport similar substrates/drugs of SLC11A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence2

 Co-transport of human SLC11A1 substrates/drugs in the health condition [5], [20], [3], [4]

Regulating Factor
mntH

Studied Tissue

 Blood

In Vivo Model

 129/SvJ mice

Detailed Description

 The protein mntH of Salmonella enterica subsp. enterica serovar Typhimurium has been reported to transport similar substrates/drugs of SLC11A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence3

 Co-transport of human SLC11A1 substrates/drugs in the health condition [3], [4], [5], [6], [18]

Regulating Factor
mntH

Detailed Description

 The protein mntH of Salmonella enterica subsp. enterica serovar Typhimurium MM1255 has been reported to transport similar substrates/drugs of SLC11A1, which affects the distribution of its substrate/drug in vivo.

   Genus: Shigella

     Shigella flexneri 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC11A1 substrates/drugs in the health condition [5], [21], [3], [4]

Regulating Factor
mntH

Detailed Description

 The protein mntH of Shigella flexneri SA100 has been reported to transport similar substrates/drugs of SLC11A1, which affects the distribution of its substrate/drug in vivo.

   Genus: Yersinia

     Yersinia pestis 

Microbe Info

Click to Show/Hide the Full List 2 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC11A1 substrates/drugs in pneumonic plague condition [5], [22], [3], [4]

Regulating Factor
mntH

Studied Phenotype

 Pneumonic plague [ICD11: 1B93.2]

Studied Tissue

 Nose

In Vivo Model

 Swiss Webster mice

Detailed Description

 The protein mnth of Yersinia pestis has been reported to transport similar substrates/drugs of SLC11A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence2

 Co-transport of human SLC11A1 substrates/drugs in the health condition [5], [22], [3], [4]

Regulating Factor
mntH

Detailed Description

 The protein mntH of Yersinia pestis KIM6 has been reported to transport similar substrates/drugs of SLC11A1, which affects the distribution of its substrate/drug in vivo.

     Yersinia pseudotuberculosis 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC11A1 substrates/drugs in the health condition [5], [23], [3], [4]

Regulating Factor
mntH

Detailed Description

 The protein mntH of Yersinia pseudotuberculosis IP 32953 has been reported to transport similar substrates/drugs of SLC11A1, which affects the distribution of its substrate/drug in vivo.
References
1 Mycobacterium tuberculosis acquires iron by cell-surface sequestration and internalization of human holo-transferrin. Nat Commun. 2014 Aug 28;5:4730.
2 Elemental analysis of Mycobacterium avium-, Mycobacterium tuberculosis-, and Mycobacterium smegmatis-containing phagosomes indicates pathogen-induced microenvironments within the host cell's endosomal system. J Immunol. 2005 Feb 1;174(3):1491-500.
3 Human iron transporters. Genes Nutr. 2011 Feb;6(1):45-54.
4 Iron transport machinery of human cells: players and their interactions. Curr Top Membr. 2012;69:67-93.
5 Manganese homeostasis and utilization in pathogenic bacteria. Mol Microbiol. 2015 Jul;97(2):216-28.
6 Manganese transport and the role of manganese in virulence. Annu Rev Microbiol. 2006;60:187-209.
7 Overexpression, purification, and site-directed spin labeling of the Nramp metal transporter from Mycobacterium leprae. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8608-13.
8 Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesis. Front Cell Infect Microbiol. 2014 Jan 24;4:2.
9 Mycobactin-mediated iron acquisition within macrophages. Nat Chem Biol. 2005 Aug;1(3):149-53.
10 Mycobacterium tuberculosis expresses a novel pH-dependent divalent cation transporter belonging to the Nramp family. J Exp Med. 1999 Sep 6;190(5):717-24.
11 Manganese homeostasis in Bacillus subtilis is regulated by MntR, a bifunctional regulator related to the diphtheria toxin repressor family of proteins. Mol Microbiol. 2000 Mar;35(6):1454-68.
12 Transport of magnesium by a bacterial Nramp-related gene. PLoS Genet. 2014 Jun 26;10(6):e1004429.
13 MntABC and MntH contribute to systemic Staphylococcus aureus infection by competing with calprotectin for nutrient manganese. Infect Immun. 2013 Sep;81(9):3395-405.
14 MntR modulates expression of the PerR regulon and superoxide resistance in Staphylococcus aureus through control of manganese uptake. Mol Microbiol. 2002 Jun;44(5):1269-86.
15 Bacterial outer membrane channel for divalent metal ion acquisition. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15390-5.
16 The mntH gene encodes the major Mn(2+) transporter in Bradyrhizobium japonicum and is regulated by manganese via the Fur protein. Mol Microbiol. 2009 Apr;72(2):399-409.
17 The manganese transporter MntH is a critical virulence determinant for Brucella abortus 2308 in experimentally infected mice. Infect Immun. 2009 Aug;77(8):3466-74.
18 The NRAMP proteins of Salmonella typhimurium and Escherichia coli are selective manganese transporters involved in the response to reactive oxygen. Mol Microbiol. 2000 Jun;36(5):1085-100.
19 Identification of the Escherichia coli K-12 Nramp orthologue (MntH) as a selective divalent metal ion transporter. Mol Microbiol. 2000 Mar;35(5):1065-78.
20 Acquisition of Mn(II) in addition to Fe(II) is required for full virulence of Salmonella enterica serovar Typhimurium. Infect Immun. 2002 Nov;70(11):6032-42.
21 Role and regulation of the Shigella flexneri sit and MntH systems. Infect Immun. 2006 Aug;74(8):4666-72.
22 Manganese transporters Yfe and MntH are Fur-regulated and important for the virulence of Yersinia pestis. Microbiology (Reading). 2012 Mar;158(Pt 3):804-815.
23 Yersinia pseudotuberculosis mntH functions in intracellular manganese accumulation, which is essential for virulence and survival in cells expressing functional Nramp1. Microbiology (Reading). 2011 Apr;157(Pt 4):1115-1122.

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