| General Information of DT | |||||
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| DT ID | DTD0080 | ||||
| Gene Name | SLC11A1 | ||||
| Protein Name | Natural resistance-associated macrophage protein 1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:5M94_A Identity:35.023% Minimized Score:-1059.962 kcal/mol Detail: Structure Info |
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| Synonyms | LSH; NRAMP; NRAMP 1; NRAMP1; SLC11A1; Solute carrier family 11 member 1 | ||||
| DT Family | Metal Ion (Mn(2+)-Iron) Transporter (NRAMP) Family ; | ||||
| Tissue Specificity | Macrophages; peripheral blood leukocytes,lung, spleen and liver. | ||||
| Function | This transporter mediates the transport of divalent metal ion (iron and manganese) and involves in iron metabolism and host resistance to certain pathogens. | ||||
| Endogenous Substrate(s) | Mn2+; Fe2+; H+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Natural resistance-associated macrophage protein 1 |
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(β) Cell Distribution Level of Natural resistance-associated macrophage protein 1 |
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(γ) Organelle Distribution Level of Natural resistance-associated macrophage protein 1 |
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Regulatory Variability Data of This DT |
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(α) Microbiota Influence of Natural resistance-associated macrophage protein 1 |
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(β) Post-translational Modification of Natural resistance-associated macrophage protein 1 |
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(γ) Transcriptional Regulation of Natural resistance-associated macrophage protein 1 |
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(δ) Epigenetic Regulation of Natural resistance-associated macrophage protein 1 |
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(ε) Exogenous Modulation of Natural resistance-associated macrophage protein 1 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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(γ) Outward/inward-facing Conformation |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Natural resistance-associated macrophage protein 1 |
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(β) Disease-specific Protein Abundances of Natural resistance-associated macrophage protein 1 |
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(γ) Species- and Tissue-specific DT Abundances |
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