Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0080 Transporter Info
Gene Name	SLC11A1
Transporter Name	Natural resistance-associated macrophage protein 1
Gene ID	6556
UniProt ID	P49279

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
CEBPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[1]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Tissue	Blood; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[2]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
NFE2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[3]
TF Protein Name	Transcription factor NF-E2 45 kDa subunit		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor NF-E2 45 kDa subunit (NFE2) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
ARNT		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[4]
TF Protein Name	Aryl hydrocarbon receptor nuclear translocator		Transcription Factor Info
Tissue	Breast; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Aryl hydrocarbon receptor nuclear translocator (ARNT) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
ASCL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[3]
TF Protein Name	Achaete-scute homolog 1		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Achaete-scute homolog 1 (ASCL1) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
HIF1A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC11A1 gene in typhoid fever condition			[5]
TF Protein Name	Hypoxia-inducible factor 1-alpha		Transcription Factor Info
Studied Phenotype	Typhoid fever [ICD11: 1A07]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	LysMcre HIF1a KO mice
Detailed Description	Hypoxia-inducible factor 1-alpha (HIF1A) has been reported to activate the transcription of SLC11A1 gene in typhoid fever condition, which leads to an increased expression of the drug transporter Natural resistance-associated macrophage protein 1.
MXI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[4]
TF Protein Name	Max-interacting protein 1		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Max-interacting protein 1 (MXI1) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
MYC		Click to Show/Hide to Show 3 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene in HL60 condition			[6]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Myc proto-oncogene protein (MYC) has been reported to bind to the transcription of SLC11A1 gene in HL60 condition, which leads to an affected expression of the drug transporter Natural resistance-associated macrophage protein 1.
Transcriptional Phenomenon2	Repression of SLC11A1 gene in medulloblastoma condition			[7]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Myc proto-oncogene protein (MYC) has been reported to repress the transcription of SLC11A1 gene in medulloblastoma condition, which leads to a decreased expression of the drug transporter Natural resistance-associated macrophage protein 1.
Transcriptional Phenomenon3	Repression of SLC11A1 gene in leukemia condition			[8]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Affected Drug/Substrate	Iron
Studied Phenotype	Leukemia [ICD11: 2A20-2B3Z]
Tissue	Blood
Related DT Changes	Down regulating
Experimental Material	Mouse leukemia cells (RAW264)
Detailed Description	Myc proto-oncogene protein (MYC) has been reported to repress the transcription of SLC11A1 gene in leukemia condition, which leads to a decreased expression of the drug transporter Natural resistance-associated macrophage protein 1.
TCF12		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[1]
TF Protein Name	Transcription factor 12		Transcription Factor Info
Tissue	Blood; Brain; Liver; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 12 (TCF12) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
TCF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[2]
TF Protein Name	Transcription factor E2-alpha		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2-alpha (TCF3) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TFAP2C		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[2]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast; Cervix; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
NR2F2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[1]
TF Protein Name	COUP transcription factor 2		Transcription Factor Info
Tissue	Breast; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	COUP transcription factor 2 (NR2F2) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
PGR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[3]
TF Protein Name	Progesterone receptor		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Progesterone receptor (PGR) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GATA1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC11A1 gene in megakaryocytes condition			[9]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC11A1 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Natural resistance-associated macrophage protein 1.
Transcriptional Phenomenon2	Direct binding to SLC11A1 gene			[3]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Erythroid transcription factor (GATA1) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 15 TF(s) Regulating This DT
BCL6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC11A1 gene in health condition			[10]
TF Protein Name	B-cell lymphoma 6 protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	B-cell lymphoma 6 protein (BCL6) has been reported to activate the transcription of SLC11A1 gene in health condition, which leads to an increased expression of the drug transporter Natural resistance-associated macrophage protein 1.
EGR1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC11A1 gene in UV irradiation condition			[11]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Early growth response protein 1 (EGR1) has been reported to activate the transcription of SLC11A1 gene in UV irradiation condition, which leads to an increased expression of the drug transporter Natural resistance-associated macrophage protein 1.
Transcriptional Phenomenon2	Binding to SLC11A1 gene in erythroleukemia condition			[12]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC11A1 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Natural resistance-associated macrophage protein 1.
KLF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[1]
TF Protein Name	Krueppel-like factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 1 (KLF1) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
KLF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[2]
TF Protein Name	Krueppel-like factor 4		Transcription Factor Info
Tissue	Pancreatic ductal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 4 (KLF4) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
KLF5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[4]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Tissue	Colon; Pancreatic ductal; Stomach
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 5 (KLF5) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
KLF9		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[3]
TF Protein Name	Krueppel-like factor 9		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 9 (KLF9) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[4]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
VEZF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[2]
TF Protein Name	Vascular endothelial zinc finger 1		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Vascular endothelial zinc finger 1 (VEZF1) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
WT1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC11A1 gene in podocyte condition			[13]
TF Protein Name	Wilms tumor protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Wilms tumor protein (WT1) has been reported to activate the transcription of SLC11A1 gene in podocyte condition, which leads to an increased expression of the drug transporter Natural resistance-associated macrophage protein 1.
YY1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC11A1 gene in melanocyte deficiency condition			[14]
TF Protein Name	Transcriptional repressor protein YY1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcriptional repressor protein YY1 (YY1) has been reported to activate the transcription of SLC11A1 gene in melanocyte deficiency condition, which leads to an increased expression of the drug transporter Natural resistance-associated macrophage protein 1.
Transcriptional Phenomenon2	Direct binding to SLC11A1 gene			[1]
TF Protein Name	Transcriptional repressor protein YY1		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Colon; Embryo; Liver; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor protein YY1 (YY1) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
ZBTB17		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC11A1 gene in leukemia condition			[8]
TF Protein Name	Zinc finger and BTB domain-containing protein 17		Transcription Factor Info
Affected Drug/Substrate	Iron
Studied Phenotype	Leukemia [ICD11: 2A20-2B3Z]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	Mouse leukemia cells (RAW264)
Detailed Description	Zinc finger and BTB domain-containing protein 17 (ZBTB17) has been reported to activate the transcription of SLC11A1 gene in leukemia condition, which leads to an increased expression of the drug transporter Natural resistance-associated macrophage protein 1.
ZBTB7A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[2]
TF Protein Name	Zinc finger and BTB domain-containing protein 7A		Transcription Factor Info
Tissue	Bone marrow; Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[4]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Bone marrow; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
ZNF384		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[3]
TF Protein Name	Zinc finger protein 384		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 384 (ZNF384) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
ZNF92		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[1]
TF Protein Name	Zinc finger protein 92		Transcription Factor Info
Tissue	Retina
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 92 (ZNF92) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
HOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[4]
TF Protein Name	Homeobox protein Hox-A1		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Homeobox protein Hox-A1 (HOXA1) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 6 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[15]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Transcription factor E2F1 (E2F1) has been reported to bind to the transcription of SLC11A1 gene in . condition, which leads to a affected expression of the drug transporter Natural resistance-associated macrophage protein 1.
Transcriptional Phenomenon2	Direct binding to SLC11A1 gene			[3]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Tissue	Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F1 (E2F1) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[1]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Bone marrow; Embryo; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
E2F7		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[3]
TF Protein Name	Transcription factor E2F7		Transcription Factor Info
Tissue	Colon; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F7 (E2F7) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
FOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[3]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Embryo; Liver; Lung; Pancreatic ductal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
FOXA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[1]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
FOXP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC11A1 gene in embryonic stem cell condition			[16]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Forkhead box protein P1 (FOXP1) has been reported to repress the transcription of SLC11A1 gene in embryonic stem cell condition, which leads to a decreased expression of the drug transporter Natural resistance-associated macrophage protein 1.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
ELF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC11A1 gene			[17]
TF Protein Name	ETS-related transcription factor Elf-1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	ETS-related transcription factor Elf-1 (ELF1) has been reported to bind to the transcription of SLC11A1 gene in . condition, which leads to a affected expression of the drug transporter Natural resistance-associated macrophage protein 1.
ERG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[2]
TF Protein Name	Transcriptional regulator ERG		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional regulator ERG (ERG) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
ETS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[4]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Lung; Prostate; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
FLI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[1]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[2]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Blood; Bone marrow; Breast; Embryo; Liver; Mesenchymal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
MYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[2]
TF Protein Name	Transcriptional activator Myb		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional activator Myb (MYB) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
SPI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC11A1 gene in HL60 condition			[17]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLC11A1 gene in HL60 condition, which leads to an affected expression of the drug transporter Natural resistance-associated macrophage protein 1.
Class3.7: ARID domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
ARID3A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[4]
TF Protein Name	AT-rich interactive domain-containing protein 3A		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	AT-rich interactive domain-containing protein 3A (ARID3A) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
KDM5B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[3]
TF Protein Name	Lysine-specific demethylase 5B		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Lysine-specific demethylase 5B (KDM5B) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
TF Superclass5: alpha-Helices exposed by beta-structures
Class5.1: MADS box factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SRF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[1]
TF Protein Name	Serum response factor		Transcription Factor Info
Tissue	Embryo; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Serum response factor (SRF) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
EBF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[1]
TF Protein Name	Transcription factor COE1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor COE1 (EBF1) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
Class6.2: STAT domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
STAT1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[18]
TF Protein Name	Signal transducer and activator of transcription 1-alpha/beta		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Signal transducer and activator of transcription 1-alpha/beta (STAT1) has been reported to bind to the transcription of SLC11A1 gene in . condition, which leads to an affected expression of the drug transporter Natural resistance-associated macrophage protein 1.
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TP63		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC11A1 gene in health condition			[19]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC11A1 gene in health condition, which leads to an affected expression of the drug transporter Natural resistance-associated macrophage protein 1.
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
RUNX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC11A1 gene in megakaryocytes condition			[9]
TF Protein Name	Runt-related transcription factor 1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC11A1 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Natural resistance-associated macrophage protein 1.
RUNX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[2]
TF Protein Name	Runt-related transcription factor 3		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Runt-related transcription factor 3 (RUNX3) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold
Class7.1: SMAD/NF-1 DNA-binding domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
NFIC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[4]
TF Protein Name	Nuclear factor 1 C-type		Transcription Factor Info
Tissue	Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear factor 1 C-type (NFIC) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.
TF Superclass10: Yet undefined DNA-binding domains
Class10.5: GTF2I domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GTF2I		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC11A1 gene			[4]
TF Protein Name	General transcription factor II-I		Transcription Factor Info
Tissue	Foreskin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	General transcription factor II-I (GTF2I) can directly bind to the SLC11A1 gene, which in turn affects the expression or function of the drug transporter Natural resistance-associated macrophage protein 1.

References
1	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-142. (ID:ENSG00000018280)
2	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
3	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
4	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
5	HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite. Blood. 2007 Oct 15;110(8):3039-48.
6	Optimization of experimental design parameters for high-throughput chromatin immunoprecipitation studies. Nucleic Acids Res. 2008;36(21):e144.
7	Silencing of thrombospondin-1 is critical for myc-induced metastatic phenotypes in medulloblastoma. Cancer Res. 2010;70(20):8199-210.
8	c-Myc represses and Miz-1 activates the murine natural resistance-associated protein 1 promoter. J Biol Chem. 2002 Sep 20;277(38):34997-5006.
9	Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
10	The transcriptional regulator BCL6 participates in the secondary gene regulatory response to vitamin D. Biochim Biophys Acta. 2015;1849(3):300-8.
11	Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip. Genome Biol. 2008;9(11):R166.
12	Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
13	Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
14	YY1 regulates melanocyte development and function by cooperating with MITF. PLoS Genet. 2012;8(5):e1002688.
15	Genome-wide analysis of transcription factor E2F1 mutant proteins reveals that N- and C-terminal protein interaction domains do not participate in targeting E2F1 to the human genome. J Biol Chem. 2011;286(14):11985-96.
16	An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 2011;147(1):132-46.
17	Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
18	MER41 repeat sequences contain inducible STAT1 binding sites. PLoS One. 2010;5(7):e11425.
19	Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.

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