Drug Transporter (DT) Information

General Information of DT
DT ID DTD0251
Gene Name SLC2A1
Protein Name Glucose transporter type 1, erythrocyte/brain
Gene ID
6513
UniProt ID
P11166
TCDB ID
2.A.1.1.28
3D Structure

Crystal Structure

Crystallisation Method:X-ray

PDB ID:5EQG

Corresponding Chain:A

Sequence Length:1-492

Detail: Struture Info

Synonyms CSE; DYT17; DYT18; DYT9; EIG12; GLUT; GLUT-1; GLUT1; GLUT1DS; HTLVR; HepG2 glucose transporter; PED; SDCHCN; SLC2A1; Solute carrier family 2, facilitated glucose transporter member 1
DT Family Major Facilitator Superfamily (MFS)
Sugar Porter (SP) Family
Tissue Specificity Detected in erythrocytes (at protein level).Expressed at variable levels in many human tissues.
Function This transporter has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake.
Endogenous Substrate(s) Dehydroascorbate; Arsenite; D-glucose
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Glucose transporter type 1, erythrocyte/brain
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Glucose transporter type 1, erythrocyte/brain
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Glucose transporter type 1, erythrocyte/brain
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Glucose transporter type 1, erythrocyte/brain
Microbiota Influence (MBI)

(β) Post-translational Modification of Glucose transporter type 1, erythrocyte/brain
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Glucose transporter type 1, erythrocyte/brain
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Glucose transporter type 1, erythrocyte/brain
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Glucose transporter type 1, erythrocyte/brain
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(α) Mutation-induced Structural Variation
Mutation-induced Structural Variation (MSV)

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

(δ) Xenobiotics-regulated Structural Variability
Xenobiotics-regulated Structural Variability (XSV)

General Variability Data of This DT

(α) Genetic Polymorphisms of Glucose transporter type 1, erythrocyte/brain
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Glucose transporter type 1, erythrocyte/brain
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
D-glucose
 Approved Drug Info Hypoglycemia 5A21; 5A41 [1]

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
2-Deoxyglucose
 Phase 1/2 Drug Info Cancer 2A00-2F9Z [3]

 Phase 3 Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Quercetin
 Phase 3 Drug Info Coronary artery disease BA6Z [2]

Endogenous Metabolites (EMs) Handled by This DT

 Endogenous Metabolites (EMs)

 Click to Show/Hide the Full List of EMs:           1 EMs in Total
EM Name PubChem CID Detail Experimental Material Ref
3-hydroxybutyrate
3541112
EM Info Unclear experiment used for identifying this EM [4]

Drug-DT Affinity Assessed by Cell Line

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:           2 Drugs in Total
Drug Name Highest Status Detail Cell Line Affinity Ref
Dehydroascorbic acid Investigative Drug Info Chinese hamster ovary (CHO) cells-GLUT1 Km =1100 microM [5]
Dehydroascorbic acid Investigative Drug Info Chinese hamster ovary (CHO) cells-GLUT1 Km =1100 microM [5]
References
1 The SLC2 (GLUT) family of membrane transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):121-38.
2 Oral Bioavailability and Disposition of Phytochemicals
3 Glutamine 161 of Glut1 glucose transporter is critical for transport activity and exofacial ligand binding. J Biol Chem. 1994 Aug 12;269(32):20533-8.
4 Epigenetic regulation of the glucose transporter gene Slc2a1 by beta-hydroxybutyrate underlies preferential glucose supply to the brain of fasted mice. Genes Cells. 2017 Jan;22(1):71-83.
5 Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid. J Biol Chem. 1997 Jul 25;272(30):18982-9.

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