General Information of Drug Transporter (DT)
DT ID	DTD0251 Transporter Info
Gene Name	SLC2A1
Protein Name	Glucose transporter type 1, erythrocyte/brain
Gene ID	6513
UniProt ID	P11166
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs710218
Site of GPD	chr1:42961547 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	T>A
Minor Allele Frequency	A=0.2196/984 (Global)
Genotype TT	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
N.A.	N.A.	In-stent Restenosis	Correlated with the higher risk for angiographically significant in-stent restenosis (comare with genotypes AA + AT)		[ 1]
Genetic Polymorphism	g.22999G>T
Allele T	Click to Show/Hide the Full List of Affected Drugs:           2 Drugs in Total
N.A.	N.A.	Human T-lymphotropic virus 1 infection	Irrelevant to the Human T-lymphotropic virus 1 infection (compare with allele G)		[ 2]
N.A.	N.A.	Human T-lymphotropic virus 1 infection	Irrelevant to the genetic susceptibility of tropical spastic paraparesis in BrazilianHuman T-lymphotropic virus 1 infected individuals (compare with allele G)		[ 2]
Genetic Polymorphism	g.15339T>C
Allele C	Click to Show/Hide the Full List of Affected Drugs:           2 Drugs in Total
N.A.	N.A.	Human T-lymphotropic virus 1 infection	Irrelevant to the Human T-lymphotropic virus 1 infection (compare with allele T)		[ 2]
N.A.	N.A.	Human T-lymphotropic virus 1 infection	Irrelevant to the genetic susceptibility of tropical spastic paraparesis in BrazilianHuman T-lymphotropic virus 1 infected individuals (compare with allele T)		[ 2]
Genetic Polymorphism	c.2841A>T
Allele T	Click to Show/Hide the Full List of Affected Drugs:           2 Drugs in Total
N.A.	N.A.	Human T-lymphotropic virus 1 infection	Irrelevant to the Human T-lymphotropic virus 1 infection (compare with allele A)		[ 2]
N.A.	N.A.	Human T-lymphotropic virus 1 infection	Irrelevant to the genetic susceptibility of tropical spastic paraparesis in BrazilianHuman T-lymphotropic virus 1 infected individuals (compare with allele A)		[ 2]
Genetic Polymorphism	rs3738514
Site of GPD	chr1:42960920 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	C>T
Minor Allele Frequency	C=0.7850/1553 (Global)
Allele T	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Platinum	N.A.	Drug Toxicity	Allele T is associated with decreased severity of Drug Toxicity when treated with platinum in people with Lung Neoplasms as compared to allele C.		[ 3]
Genetic Polymorphism	rs4658
Site of GPD	chr1:42926579 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	C>G / C>T
Minor Allele Frequency	C=0.6050/1197 (Global)
Genotype CC	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Platinum	N.A.	Drug Toxicity	Genotype CC is associated with decreased severity of Drug Toxicity when treated with platinum in people with as compared to genotypes CG + GG.		[ 3]
References
1	Functional polymorphism rs710218 in the gene coding GLUT1 protein is associated with in-stent restenosis. Biomark Med. 2015;9(8):743-50.
2	Polymorphisms at GLUT1 gene are not associated with the development of TSP/HAM in Brazilian HTLV-1 infected individuals and the discovery of a new polymorphism at GLUT1 gene. J Med Virol. 2009 Mar;81(3):552-7.
3	Effect of transporter and DNA repair gene polymorphisms to lung cancer chemotherapy toxicity. Tumour Biol. 2016 Feb;37(2):2275-84.

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