Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00260
|
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| Drug Name |
Dehydroascorbic acid
|
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| Synonyms |
dehydroascorbate
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD11:N.A.] | Investigative | ||||
| Structure |
|
 |
||||
| 3D MOL | 2D MOL | |||||
| Formula |
C6H6O6
|
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| Canonical SMILES |
C(C(C1C(=O)C(=O)C(=O)O1)O)O
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| InChI |
InChI=1S/C6H6O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-8H,1H2/t2-,5+/m0/s1
|
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| InChIKey |
SBJKKFFYIZUCET-JLAZNSOCSA-N
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| CAS Number |
CAS 490-83-5
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| Pharmaceutical Properties | Molecular Weight | 174.11 | Topological Polar Surface Area | 101 | ||
| Heavy Atom Count | 12 | Rotatable Bond Count | 2 | |||
| Hydrogen Bond Donor Count | 2 | Hydrogen Bond Acceptor Count | 6 | |||
| XLogP |
-1
|
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| PubChem CID | ||||||
| PubChem SID |
10298636
,104623586
,117613608
,131316051
,135874386
,137003204
,140408100
,15219547
,162199578
,162221209
,164792853
,175444061
,178101444
,179150496
,198982379
,223509582
,226447355
,241082335
,24712288
,24855820
,24894191
,252346267
,29204021
,36884658
,53789738
,57403417
,68530687
,77327812
,7786
,88835380
,92297615
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| ChEBI ID |
ChEBI:27956
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | GLUT1 | Transporter Info | Glucose transporter type 1 | Substrate | [1] | |
| GLUT14 | Transporter Info | Glucose transporter type 14 | Substrate | [2] | ||
| Drug-Transporter Activity Data | ||||||
| Drug-Transporter Activity Data | GLUT1 | Transporter Info | Km =1100 microM | Chinese hamster ovary (CHO) cells-GLUT1 | [1] | |
| References | ||||||
| 1 | Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid. J Biol Chem. 1997 Jul 25;272(30):18982-9. | |||||
| 2 | The SLC2A14 gene, encoding the novel glucose/dehydroascorbate transporter GLUT14, is associated with inflammatory bowel disease. Am J Clin Nutr. 2017 Dec;106(6):1508-1513. | |||||
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