Drug Transporter (DT) Information

General Information of DT
DT ID DTD0256
Gene Name SLC2A14
Protein Name Glucose transporter type 14
Gene ID
144195
UniProt ID
Q8TDB8
TCDB ID
2.A.1.1.90
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:4ZW9_A

Identity:94.737%

Minimized Score:-1440.603 kcal/mol

Detail: Structure Info

Synonyms GLUT-14; GLUT14; SLC2A14; SLC2A3P3; Solute carrier family 2, facilitated glucose transporter member 14
DT Family Major Facilitator Superfamily (MFS)
Sugar Porter (SP) Family
Tissue Specificity Expressed mainly in testis.
Function This transporter may have a specific function related to spermatogenesis and facilitates glucose transport.
Endogenous Substrate(s) Glucose
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Glucose transporter type 14
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Glucose transporter type 14
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Glucose transporter type 14
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Glucose transporter type 14
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Glucose transporter type 14
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Glucose transporter type 14
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Glucose transporter type 14
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

General Variability Data of This DT

(α) Genetic Polymorphisms of Glucose transporter type 14
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Glucose transporter type 14
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
2-Deoxyglucose
 Phase 1/2 Drug Info Cancer 2A00-2F9Z [1]
References
1 The SLC2A14 gene, encoding the novel glucose/dehydroascorbate transporter GLUT14, is associated with inflammatory bowel disease. Am J Clin Nutr. 2017 Dec;106(6):1508-1513.

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