Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0251 Transporter Info
Gene Name	SLC2A1
Transporter Name	Glucose transporter type 1, erythrocyte/brain
Gene ID	6513
UniProt ID	P11166

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 9 TF(s) Regulating This DT
ATF2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[1]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-2		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-dependent transcription factor ATF-2 (ATF2) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
ATF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC2A1 gene in glioblastoma multiforme condition			[2]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Cyclic AMP-dependent transcription factor ATF-3 (ATF3) has been reported to repress the transcription of SLC2A1 gene in glioblastoma multiforme condition, which leads to a decreased expression of the drug transporter Glucose transporter type 1.
BACH2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[3]
TF Protein Name	Transcription regulator protein BACH2		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription regulator protein BACH2 (BACH2) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
FOSL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[4]
TF Protein Name	Fos-related antigen 1		Transcription Factor Info
Tissue	Bone marrow; Breast; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 1 (FOSL1) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
FOSL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[4]
TF Protein Name	Fos-related antigen 2		Transcription Factor Info
Tissue	Brain; Breast; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 2 (FOSL2) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
JUN		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A1 gene in Coronary artery disease condition			[5]
TF Protein Name	Transcription factor Jun		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor Jun (JUN) has been reported to bind to the SLC2A1 gene in Coronary artery disease condition, which leads to a affected expression of the drug transporter Glucose transporter type 1.
JUND		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A1 gene in coronary artery disease condition			[5]
TF Protein Name	Transcription factor JunD		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor JunD (JUND) has been reported to bind to the transcription of SLC2A1 gene in coronary artery disease condition, which leads to an affected expression of the drug transporter Glucose transporter type 1.
NFE2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[1]
TF Protein Name	Transcription factor NF-E2 45 kDa subunit		Transcription Factor Info
Tissue	Blood; Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor NF-E2 45 kDa subunit (NFE2) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
NFE2L2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A1 gene in health condition			[6]
TF Protein Name	Nuclear factor erythroid 2-related factor 2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Nuclear factor erythroid 2-related factor 2 (NFE2L2) has been reported to activate the transcription of SLC2A1 gene in health condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 16 TF(s) Regulating This DT
AHR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC2A1 gene in teratocarcinoma condition			[7]
TF Protein Name	Aryl hydrocarbon receptor		Transcription Factor Info
Affected Drug/Substrate	Glucose
Studied Phenotype	Teratocarcinoma [ICD11: 2C12.0Y]
Tissue	Embryo
Related DT Changes	Down regulating
Experimental Material	Mouse teratocarcinoma cells (P19)
Detailed Description	Aryl hydrocarbon receptor (AHR) has been reported to repress the transcription of SLC2A1 gene in teratocarcinoma condition, which leads to a decreased expression of the drug transporter Glucose transporter type 1.
ASCL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[3]
TF Protein Name	Achaete-scute homolog 1		Transcription Factor Info
Tissue	Embryo; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Achaete-scute homolog 1 (ASCL1) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
EPAS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC2A1 gene in health condition			[8]
TF Protein Name	Endothelial PAS domain-containing protein 1		Transcription Factor Info
Affected Drug/Substrate	Glucose
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Embryo
Related DT Changes	Down regulating
Experimental Material	Mouse white adipose tissue preadipocytes cells (3T3-L1)
Detailed Description	Endothelial PAS domain-containing protein 1 (EPAS1) has been reported to repress the transcription of SLC2A1 gene in health condition, which leads to a decreased expression of the drug transporter Glucose transporter type 1.
HIF1A		Click to Show/Hide to Show 12 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A1 gene in ataxia Telangiectasia condition			[9]
TF Protein Name	Hypoxia-inducible factor 1-alpha		Transcription Factor Info
Affected Drug/Substrate	Glucose
Studied Phenotype	Ataxia telangiectasia [ICD11: 4A01.31]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	Human ataxia telangiectasia syndrome cells (GM03332)
Detailed Description	Hypoxia-inducible factor 1-alpha (HIF1A) has been reported to activate the transcription of SLC2A1 gene in ataxia Telangiectasia condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
Transcriptional Phenomenon2	Activation of SLC2A1 gene in gestational choriocarcinoma condition			[10]
TF Protein Name	Hypoxia-inducible factor 1-alpha		Transcription Factor Info
Affected Drug/Substrate	Glucose
Studied Phenotype	Gestational choriocarcinoma [ICD11: 2C75]
Tissue	Trophoderm
Related DT Changes	Up regulating
Experimental Material	Human gestational choriocarcinoma cells (BeWo)
Detailed Description	Hypoxia-inducible factor 1-alpha (HIF1A) has been reported to activate the transcription of SLC2A1 gene in gestational choriocarcinoma condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
Transcriptional Phenomenon3	Activation of SLC2A1 gene in health condition			[11]
TF Protein Name	Hypoxia-inducible factor 1-alpha		Transcription Factor Info
Affected Drug/Substrate	Glucose
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Knee
Related DT Changes	Up regulating
Experimental Material	C57BL/6 mice
Detailed Description	Hypoxia-inducible factor 1-alpha (HIF1A) has been reported to activate the transcription of SLC2A1 gene in health condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
Transcriptional Phenomenon4	Activation of SLC2A1 gene in pregnancy condition			[12]
TF Protein Name	Hypoxia-inducible factor 1-alpha		Transcription Factor Info
Affected Drug/Substrate	Glucose
Studied Phenotype	Pregnancy [ICD11: JA00-JA2Z]
Tissue	Breast
Related DT Changes	Up regulating
Experimental Material	C57BL/6 mice
Detailed Description	Hypoxia-inducible factor 1-alpha (HIF1A) has been reported to activate the transcription of SLC2A1 gene in pregnancy condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
Transcriptional Phenomenon5	Activation of SLC2A1 gene in hypoxia condition			[13]
TF Protein Name	Hypoxia-inducible factor 1-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Hypoxia-inducible factor 1-alpha (HIF1A) has been reported to activate the transcription of SLC2A1 gene in hypoxia condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
Transcriptional Phenomenon6	Activation of SLC2A1 gene in mammary gland cancer condition
TF Protein Name	Hypoxia-inducible factor 1-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Hypoxia-inducible factor 1-alpha (HIF1A) has been reported to activate the transcription of SLC2A1 gene in mammary gland cancer condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
Transcriptional Phenomenon7	Activation of SLC2A1 gene in breast cancer condition			[14]
TF Protein Name	Hypoxia-inducible factor 1-alpha		Transcription Factor Info
Studied Phenotype	Breast cancer [ICD11: 2C60-2C6Z]
Tissue	Breast
Related DT Changes	Up regulating
Experimental Material	Human invasive breast carcinoma of no special type cells (MCF-7)
Detailed Description	Hypoxia-inducible factor 1-alpha (HIF1A) has been reported to activate the transcription of SLC2A1 gene in breast cancer condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
Transcriptional Phenomenon8	Activation of SLC2A1 gene in ovarian cancer condition			[15]
TF Protein Name	Hypoxia-inducible factor 1-alpha		Transcription Factor Info
Studied Phenotype	Ovarian cancer [ICD11: 2C73]
Tissue	Ovary
Related DT Changes	Up regulating
Experimental Material	human ovarian adenocarcinoma cell isolates
Detailed Description	Hypoxia-inducible factor 1-alpha (HIF1A) has been reported to activate the transcription of SLC2A1 gene in ovarian cancer condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
Transcriptional Phenomenon9	Activation of SLC2A1 gene in prostate cancer condition			[16]
TF Protein Name	Hypoxia-inducible factor 1-alpha		Transcription Factor Info
Studied Phenotype	Prostate cancer [ICD11: 2C82]
Tissue	Prostate
Related DT Changes	Up regulating
Experimental Material	Human prostate carcinoma cells (LNCaP)
Detailed Description	Hypoxia-inducible factor 1-alpha (HIF1A) has been reported to activate the transcription of SLC2A1 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
Transcriptional Phenomenon10	Activation of SLC2A1 gene in sARS-CoV-2 infection condition			[17]
TF Protein Name	Hypoxia-inducible factor 1-alpha		Transcription Factor Info
Studied Phenotype	SARS-CoV-2 infection [ICD11: 1D92]
Tissue	Lung
Related DT Changes	Up regulating
Experimental Material	Syrian hamsters
Detailed Description	Hypoxia-inducible factor 1-alpha (HIF1A) has been reported to activate the transcription of SLC2A1 gene in sARS-CoV-2 infection condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
Transcriptional Phenomenon11	Activation of SLC2A1 gene in hepatoblastoma condition			[18]
TF Protein Name	Hypoxia-inducible factor 1-alpha		Transcription Factor Info
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	up regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Hypoxia-inducible factor 1-alpha (HIF1A), influenced by the exogenous ibuprofen, has been reported to activate the transcription of SLC2A1 gene in hepatoblastoma condition , which leads to an increased expression of the drug transporter Glucose transporter type 1.
Transcriptional Phenomenon12	Activation of SLC2A1 gene in hepatocellular carcinoma condition			[19]
TF Protein Name	Hypoxia-inducible factor 1-alpha		Transcription Factor Info
Studied Phenotype	Hepatocellular carcinoma [ICD11: 2C12.02]
Tissue	Liver
Related DT Changes	up regulating
Experimental Material	Human childhood hepatocellular carcinoma cells (Hep3B)
Detailed Description	Hypoxia-inducible factor 1-alpha (HIF1A), influenced by the exogenous ibuprofen, has been reported to activate the transcription of SLC2A1 gene in hepatocellular carcinoma condition , which leads to an increased expression of the drug transporter Glucose transporter type 1.
MITF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A1 gene in MELANOMA condition			[20]
TF Protein Name	Microphthalmia-associated transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC2A1 gene in MELANOMA condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
MXI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[21]
TF Protein Name	Max-interacting protein 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Cervix; Embryo; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Max-interacting protein 1 (MXI1) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
MYC		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC2A1 gene in Burkitt lymphoma condition			[22]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Myc proto-oncogene protein (MYC) has been reported to repress the transcription of SLC2A1 gene in Burkitt lymphoma condition, which leads to a decreased expression of the drug transporter Glucose transporter type 1.
Transcriptional Phenomenon2	Activation of SLC2A1 gene in liver cancer condition			[23]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Studied Phenotype	Liver cancer [ICD11: 2C12]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	BALB/c mice
Detailed Description	Myc proto-oncogene protein (MYC) has been reported to activate the transcription of SLC2A1 gene in liver cancer condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
MYOD1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC2A1 gene in health condition			[24]
TF Protein Name	Myoblast determination protein 1		Transcription Factor Info
Affected Drug/Substrate	Glucose
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Skeletal muscle
Related DT Changes	Down regulating
Experimental Material	Rat skeletal muscle myoblast cells (L6E9)
Detailed Description	Myoblast determination protein 1 (MYOD1) has been reported to repress the transcription of SLC2A1 gene in health condition, which leads to a decreased expression of the drug transporter Glucose transporter type 1.
SREBF2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A1 gene in glioma condition			[25]
TF Protein Name	Sterol regulatory element-binding protein 2		Transcription Factor Info
Studied Phenotype	Glioma [ICD11: 2A00.0]
Tissue	Brain
Related DT Changes	Up regulating
Experimental Material	human glioma cell isolates
Detailed Description	Sterol regulatory element-binding protein 2 (SREBF2) has been reported to activate the transcription of SLC2A1 gene in glioma condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
TCF12		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[3]
TF Protein Name	Transcription factor 12		Transcription Factor Info
Tissue	Blood; Brain; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 12 (TCF12) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
TCF21		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene in Coronary artery disease condition			[5]
TF Protein Name	Transcription factor 21		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor 21 (TCF21) has been reported to bind to the SLC2A1 gene in Coronary artery disease condition, which affects the expression or function of the drug transporter Glucose transporter type 1.
TCF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[4]
TF Protein Name	Transcription factor E2-alpha		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2-alpha (TCF3) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
TCF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A1 gene in glioblastoma multiforme condition			[26]
TF Protein Name	Transcription factor 4		Transcription Factor Info
Affected Drug/Substrate	Temozolomide
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor 4 (TCF4) has been reported to bind to the transcription of SLC2A1 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Glucose transporter type 1.
TFAP4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[21]
TF Protein Name	Transcription factor AP-4		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-4 (TFAP4) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
TWIST1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A1 gene in health condition			[27]
TF Protein Name	Twist-related protein 1		Transcription Factor Info
Affected Drug/Substrate	Glucose
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Kidney
Related DT Changes	Up regulating
Experimental Material	Human kidney human embryonic kidney 293T cells (HEK 293T)
Detailed Description	Twist-related protein 1 (TWIST1) has been reported to activate the transcription of SLC2A1 gene in health condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
USF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[21]
TF Protein Name	Upstream stimulatory factor 1		Transcription Factor Info
Tissue	Bone marrow; Brain; Embryo; Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Upstream stimulatory factor 1 (USF1) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TFAP2C		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[1]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast; Cervix; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 11 TF(s) Regulating This DT
AR		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A1 gene in prostate cancer condition			[28]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Androgen receptor (AR) has been reported to activate the transcription of SLC2A1 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
Transcriptional Phenomenon2	Binding to SLC2A1 gene in prostate cancer condition			[29]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the transcription of SLC2A1 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Glucose transporter type 1.
ESR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A1 gene in breast cancer condition			[30]
TF Protein Name	Estrogen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Estrogen receptor (ESR1) has been reported to bind to the SLC2A1 gene in breast cancer condition, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
ESR2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC2A1 gene in breast cancer condition			[30]
TF Protein Name	Estrogen receptor beta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Estrogen receptor beta (ESR2) has been reported to repress the transcription of SLC2A1 gene in breast cancer condition, which leads to a decreased expression of the drug transporter Glucose transporter type 1.
HNF4A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A1 gene			[31]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC2A1 gene in . condition, which leads to a affected expression of the drug transporter Glucose transporter type 1.
HNF4G		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[21]
TF Protein Name	Hepatocyte nuclear factor 4-gamma		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 4-gamma (HNF4G) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
NR1H3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A1 gene in atherosclerotic foam cells condition			[32]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Affected Drug/Substrate	T0901317
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of SLC2A1 gene in atherosclerotic foam cells condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
NR3C1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A1 gene in ER(-) breast cancer condition			[33]
TF Protein Name	Glucocorticoid receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Glucocorticoid receptor (NR3C1) has been reported to activate the transcription of SLC2A1 gene in ER(-) breast cancer condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
Transcriptional Phenomenon2	Activation of SLC2A1 gene in pregnancy condition			[34]
TF Protein Name	Glucocorticoid receptor		Transcription Factor Info
Studied Phenotype	Pregnancy [ICD11: JA00-JA2Z]
Tissue	Trophoderm
Related DT Changes	Up regulating
Experimental Material	human mononucleated trophoblast cell isolates
Detailed Description	Glucocorticoid receptor (NR3C1) has been reported to activate the transcription of SLC2A1 gene in pregnancy condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
PGR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A1 gene in pregnancy condition			[35]
TF Protein Name	Progesterone receptor		Transcription Factor Info
Studied Phenotype	Pregnancy [ICD11: JA00-JA2Z]
Tissue	Endometrium
Related DT Changes	Up regulating
Experimental Material	Suffolk sheep
Detailed Description	Progesterone receptor (PGR) has been reported to activate the transcription of SLC2A1 gene in pregnancy condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
PPARD		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A1 gene in myofibroblasts condition			[36]
TF Protein Name	Peroxisome proliferator-activated receptor delta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Peroxisome proliferator-activated receptor delta (PPARD) has been reported to activate the transcription of SLC2A1 gene in myofibroblasts condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
Transcriptional Phenomenon2	Repression of SLC2A1 gene in health condition			[37]
TF Protein Name	Peroxisome proliferator-activated receptor delta		Transcription Factor Info
Affected Drug/Substrate	Hexose
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Aorta
Related DT Changes	Down regulating
Experimental Material	Bovine aortic endothelial cells
Detailed Description	Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of SLC2A1 gene in health condition, which leads to a decreased expression of the drug transporter Glucose transporter type 1.
PPARG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A1 gene in health condition			[38]
TF Protein Name	Peroxisome proliferator-activated receptor gamma		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Embryo
Related DT Changes	up regulating
Experimental Material	Mouse differentiated adipocytes (3T3-L1)
Detailed Description	Peroxisome proliferator-activated receptor gamma (PPARG), influenced by the exogenous rosiglitazone, has been reported to activate the transcription of SLC2A1 gene in health condition , which leads to an increased expression of the drug transporter Glucose transporter type 1.
VDR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A1 gene in THP-1 human monocytic leukemia cells			[39]
TF Protein Name	Vitamin D3 receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Vitamin D3 receptor (VDR) has been reported to bind to the transcription of SLC2A1 gene in THP-1 human monocytic leukemia cells, which leads to an affected expression of the drug transporter Glucose transporter type 1.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
GATA1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A1 gene in hematopoiesis condition			[40]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC2A1 gene in hematopoiesis condition, which leads to an affected expression of the drug transporter Glucose transporter type 1.
Transcriptional Phenomenon2	Binding to SLC2A1 gene in megakaryocytes condition			[41]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC2A1 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Glucose transporter type 1.
GATA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A1 gene in hematopoiesis condition			[40]
TF Protein Name	Endothelial transcription factor GATA-2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Endothelial transcription factor GATA-2 (GATA2) has been reported to activate the transcription of SLC2A1 gene in hematopoiesis condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
GATA4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A1 gene in gastric cancer condition			[42]
TF Protein Name	Transcription factor GATA-4		Transcription Factor Info
Affected Drug/Substrate	Metformin
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor GATA-4 (GATA4) has been reported to activate the transcription of SLC2A1 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
GATA6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A1 gene in gastric cancer condition			[42]
TF Protein Name	Transcription factor GATA-6		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor GATA-6 (GATA6) has been reported to activate the transcription of SLC2A1 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 14 TF(s) Regulating This DT
EGR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A1 gene in erythroleukemia condition			[43]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC2A1 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Glucose transporter type 1.
KLF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[21]
TF Protein Name	Krueppel-like factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 1 (KLF1) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
KLF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[1]
TF Protein Name	Krueppel-like factor 3		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 3 (KLF3) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
KLF5		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A1 gene in gastric cancer condition			[42]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Krueppel-like factor 5 (KLF5) has been reported to activate the transcription of SLC2A1 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
Transcriptional Phenomenon2	Direct binding to SLC2A1 gene			[3]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Tissue	Colon; Pancreatic ductal; Stomach
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 5 (KLF5) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
KLF9		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[4]
TF Protein Name	Krueppel-like factor 9		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 9 (KLF9) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[1]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
MECOM		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[21]
TF Protein Name	Histone-lysine N-methyltransferase MECOM		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Histone-lysine N-methyltransferase MECOM (MECOM) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
SP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A1 gene in health condition			[24]
TF Protein Name	Transcription factor Sp1		Transcription Factor Info
Affected Drug/Substrate	Glucose
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Skeletal muscle
Related DT Changes	Up regulating
Experimental Material	Rat skeletal muscle myoblast cells (L6E9)
Detailed Description	Transcription factor Sp1 (SP1) has been reported to activate the transcription of SLC2A1 gene in health condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
SP4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[3]
TF Protein Name	Transcription factor Sp4		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor Sp4 (SP4) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
WT1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A1 gene in podocyte condition			[44]
TF Protein Name	Wilms tumor protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Wilms tumor protein (WT1) has been reported to activate the transcription of SLC2A1 gene in podocyte condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
ZBTB7A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[4]
TF Protein Name	Zinc finger and BTB domain-containing protein 7A		Transcription Factor Info
Tissue	Bone marrow; Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
ZFX		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[1]
TF Protein Name	Zinc finger X-chromosomal protein		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger X-chromosomal protein (ZFX) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[3]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Bone marrow; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
ZNF92		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[4]
TF Protein Name	Zinc finger protein 92		Transcription Factor Info
Tissue	Retina
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 92 (ZNF92) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
CUX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A1 gene in multiple human cancer types condition			[45]
TF Protein Name	Homeobox protein cut-like 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Homeobox protein cut-like 1 (CUX1) has been reported to activate the transcription of SLC2A1 gene in multiple human cancer types condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
LHX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[1]
TF Protein Name	LIM/homeobox protein Lhx2		Transcription Factor Info
Tissue	Epithelium
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	LIM/homeobox protein Lhx2 (LHX2) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
PBX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[3]
TF Protein Name	Pre-B-cell leukemia transcription factor 1		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 1 (PBX1) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
PBX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[4]
TF Protein Name	Pre-B-cell leukemia transcription factor 3		Transcription Factor Info
Tissue	Blood; Brain; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
E2F7		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[21]
TF Protein Name	Transcription factor E2F7		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F7 (E2F7) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
FOXM1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A1 gene in breast cancer condition			[46]
TF Protein Name	Forkhead box protein M1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Forkhead box protein M1 (FOXM1) has been reported to activate the transcription of SLC2A1 gene in breast cancer condition, which leads to an increased expression of the drug transporter Glucose transporter type 1.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 9 TF(s) Regulating This DT
EHF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[1]
TF Protein Name	ETS homologous factor		Transcription Factor Info
Tissue	Bronchus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS homologous factor (EHF) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
ELK3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A1 gene in hypoxia condition			[47]
TF Protein Name	ETS domain-containing protein Elk-3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	ETS domain-containing protein Elk-3 (ELK3) has been reported to bind to the transcription of SLC2A1 gene in hypoxia condition, which leads to an affected expression of the drug transporter Glucose transporter type 1.
ETV1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[3]
TF Protein Name	ETS translocation variant 1		Transcription Factor Info
Tissue	Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS translocation variant 1 (ETV1) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
FLI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A1 gene in megakaryocytes condition			[41]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC2A1 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Glucose transporter type 1.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[4]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Blood; Bone marrow; Liver; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
IRF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[3]
TF Protein Name	Interferon regulatory factor 1		Transcription Factor Info
Tissue	Bone marrow; Pancreatic ductal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Interferon regulatory factor 1 (IRF1) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
IRF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[21]
TF Protein Name	Interferon regulatory factor 4		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Interferon regulatory factor 4 (IRF4) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
MYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[4]
TF Protein Name	Transcriptional activator Myb		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional activator Myb (MYB) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
SPI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A1 gene in K562 cells			[48]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLC2A1 gene in K562 cells, which leads to an affected expression of the drug transporter Glucose transporter type 1.
TF Superclass5: alpha-Helices exposed by beta-structures
Class5.1: MADS box factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SRF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[21]
TF Protein Name	Serum response factor		Transcription Factor Info
Tissue	Embryo; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Serum response factor (SRF) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
EBF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[21]
TF Protein Name	Transcription factor COE1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor COE1 (EBF1) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
TP53		Click to Show/Hide to Show 4 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A1 gene in tumor condition			[49]
TF Protein Name	Cellular tumor antigen p53		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC2A1 gene in tumor condition, which leads to an affected expression of the drug transporter Glucose transporter type 1.
Transcriptional Phenomenon2	Repression of SLC2A1 gene in osteosarcoma condition			[50]
TF Protein Name	Cellular tumor antigen p53		Transcription Factor Info
Affected Drug/Substrate	Glucose
Studied Phenotype	Osteosarcoma [ICD11: 2B51]
Tissue	Bone
Related DT Changes	Down regulating
Experimental Material	Human osteosarcoma cells (Saos-2)
Detailed Description	Cellular tumor antigen p53 (TP53) has been reported to repress the transcription of SLC2A1 gene in osteosarcoma condition, which leads to a decreased expression of the drug transporter Glucose transporter type 1.
Transcriptional Phenomenon3	Repression of SLC2A1 gene in colon cancer condition			[51]
TF Protein Name	Cellular tumor antigen p53		Transcription Factor Info
Studied Phenotype	Colon cancer [ICD11: 2B90]
Tissue	Colon
Related DT Changes	Down regulating
Experimental Material	Human colon carcinoma cells (HCT-116)
Detailed Description	Cellular tumor antigen p53 (TP53) has been reported to repress the transcription of SLC2A1 gene in colon cancer condition, which leads to a decreased expression of the drug transporter Glucose transporter type 1.
Transcriptional Phenomenon4	Repression of SLC2A1 gene in wilms tumor condition			[52]
TF Protein Name	Cellular tumor antigen p53		Transcription Factor Info
Studied Phenotype	Wilms tumor [ICD11: 2C90.Y]
Tissue	Kidney
Related DT Changes	Down regulating
Experimental Material	human Wilms tumor cell isolates
Detailed Description	Cellular tumor antigen p53 (TP53) has been reported to repress the transcription of SLC2A1 gene in wilms tumor condition, which leads to a decreased expression of the drug transporter Glucose transporter type 1.
TP63		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A1 gene in epithelial to mesenchymal transition condition			[53]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC2A1 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Glucose transporter type 1.
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
RUNX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A1 gene in megakaryocytes condition			[41]
TF Protein Name	Runt-related transcription factor 1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC2A1 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Glucose transporter type 1.
Class6.7: Grainyhead domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GRHL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[1]
TF Protein Name	Grainyhead-like protein 2 homolog		Transcription Factor Info
Tissue	Breast; Bronchus; Ovary; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold
Class7.1: SMAD/NF-1 DNA-binding domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
NFIC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[1]
TF Protein Name	Nuclear factor 1 C-type		Transcription Factor Info
Tissue	Brain; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear factor 1 C-type (NFIC) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
TF Superclass10: Yet undefined DNA-binding domains
Class10.1: Other factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GTF2B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[3]
TF Protein Name	Transcription initiation factor IIB		Transcription Factor Info
Tissue	Cervix; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription initiation factor IIB (GTF2B) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.
Class10.5: GTF2I domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GTF2I		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A1 gene			[4]
TF Protein Name	General transcription factor II-I		Transcription Factor Info
Tissue	Foreskin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	General transcription factor II-I (GTF2I) can directly bind to the SLC2A1 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 1.

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