| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0520 | ||||
| Gene Name | CACNA1E | ||||
| Protein Name | Voltage-gated calcium channel alpha Cav2.3 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:6JPA_A Identity:48.82% Minimized Score:-1476.087 kcal/mol Detail: Structure Info |
||||
| Synonyms | BII; Brain calcium channel II; CACH6; CACNA1E; CACNL1A6; Calcium channel, L type, alpha-1 polypeptide, isoform 6; Cav2.3; EIEE69; Voltage-dependent R-type calcium channel subunit alpha-1E; gm139; Voltage-gated calcium channel subunit alpha Cav2.3 | ||||
| DT Family | Voltage-Gated Ion Channel (VIC) Superfamily ; | ||||
| Tissue Specificity | Expressed in neuronal tissues and in kidney. | ||||
| Function | This voltage-sensitive calcium transporter mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. | ||||
| Endogenous Substrate(s) | Ca2+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
|
Regulatory Variability Data of This DT (VARIDT 4.0) |
|||||
|
(α) Tissue Distribution Level of Voltage-gated calcium channel alpha Cav2.3 |
|||||
|
(β) Cell Distribution Level of Voltage-gated calcium channel alpha Cav2.3 |
|||||
|
(γ) Organelle Distribution Level of Voltage-gated calcium channel alpha Cav2.3 |
|||||
|
Regulatory Variability Data of This DT |
|||||
|
(β) Post-translational Modification of Voltage-gated calcium channel alpha Cav2.3 |
|||||
|
(δ) Epigenetic Regulation of Voltage-gated calcium channel alpha Cav2.3 |
|||||
|
(ε) Exogenous Modulation of Voltage-gated calcium channel alpha Cav2.3 |
|||||
|
Structural Variability Data of This DT |
|||||
|
(α) Mutation-induced Structural Variation |
|||||
|
(β) Inter-species Structural Differences |
|||||
|
General Variability Data of This DT |
|||||
|
(α) Genetic Polymorphisms of Voltage-gated calcium channel alpha Cav2.3 |
|||||
|
(β) Disease-specific Protein Abundances of Voltage-gated calcium channel alpha Cav2.3 |
|||||
|
(γ) Species- and Tissue-specific DT Abundances |
|||||
If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.