Detail Information of Genetic Polymorphisms
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0520 Transporter Info | ||||
| Gene Name | CACNA1E | ||||
| Protein Name | Voltage-gated calcium channel alpha Cav2.3 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Genetic Polymorphisms of DT (GPD) | |||||
| Genetic Polymorphism | rs12060765 | ||||
| Site of GPD | chr1:181490624 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | G>T | ||||
| Minor Allele Frequency | T=0.0136/61 (Global) | ||||
| Genotype TT | Click to Show/Hide the Full List of Affected Drugs: 2 Drugs in Total | ||||
| Antipsychotics | N.A. | Hypertension | Genotype TT is associated with increased response to antipsychotics in people with Schizophrenia as compared to genotype GG. | [ 1] | |
| Antipsychotics | N.A. | Schizophrenia | Correlated with the increased drug response in patients (compare with genotype GG) | [ 1] | |
| Genetic Polymorphism | rs3845446 | ||||
| Site of GPD | chr1:181797301 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | T>C | ||||
| Minor Allele Frequency | T=0.8870/1755 (Global) | ||||
| Genotype TT | Click to Show/Hide the Full List of Affected Drugs: 2 Drugs in Total | ||||
| Fentanyl | N.A. | Hypertension | Genotype TT is not associated with dose of fentanyl in people with Pain, Postoperative as compared to genotypes CC + CT. | [ 2] | |
| Fentanyl | N.A. | Pain, Postoperative | Genotype TT is not associated with dose of fentanyl in people with Pain, Postoperative as compared to genotypes CC + CT. | [ 2] | |
| Genotypes CC + CT | Click to Show/Hide the Full List of Affected Drugs: 2 Drugs in Total | ||||
| Fentanyl | N.A. | Hypertension | Genotypes CC + CT are associated with decreased dose of fentanyl in people with Pain, Postoperative as compared to genotype TT. | [ 3] | |
| Fentanyl | N.A. | Pain, Postoperative | Genotypes CC + CT are associated with decreased dose of fentanyl in people with Pain, Postoperative as compared to genotype TT. | [ 3] | |
| Genotype CC | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Fentanyl | N.A. | Pain, Postoperative | Patients with postoperative pain and the CC genotype may have decreased fentanyl dose requirements as compared to patients with the TT genotype. However, another study failed to find a significant association between this variant and fentanyl dose requirements. Other genetic or clinical factors may also affect a patient's fentanyl dose requirements. | [ 2] | |
| Genotype CT | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Fentanyl | N.A. | Pain, Postoperative | Patients with postoperative pain and the CT genotype may have decreased fentanyl dose requirements as compared to patients with the TT genotype. However, another study failed to find a significant association between this variant and fentanyl dose requirements. Other genetic or clinical factors may also affect a patient's fentanyl dose requirements. | [ 2] | |
| References | |||||
| 1 | Variation within voltage-gated calcium channel genes and antipsychotic treatment response in a South African first episode schizophrenia cohort. Pharmacogenomics J. 2019 Feb;19(1):109-114. | ||||
| 2 | Prediction formulas for individual opioid analgesic requirements based on genetic polymorphism analyses. PLoS One. 2015 Jan 23;10(1):e0116885. | ||||
| 3 | Association between genetic polymorphisms in Ca(v)2.3 (R-type) Ca2+ channels and fentanyl sensitivity in patients undergoing painful cosmetic surgery. PLoS One. 2013;8(8):e70694. | ||||
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