Detail Information of DT Wildtype Structure
| General Information of Drug Transporter (DT) | ||||||
|---|---|---|---|---|---|---|
| DT ID | DTD0520 Transporter Info | |||||
| Gene Name | CACNA1E | |||||
| Transporter Name | Voltage-gated calcium channel alpha Cav2.3 | |||||
| Gene ID | ||||||
| UniProt ID | ||||||
| Modelled Structures of This DT | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Detail Information of Structural Model | ||||||
| Method | Homology modeling | |||||
| Template PDB | 6JPA_A | Identity | 48.82% | |||
| Performance | Minimized Score | -1476.087 kcal/mol | ||||
| Ramachandra Favored | Medium |
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| QMEANBrane Quality | High |
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| Ramachandran Plot |
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| Click to Save Ramachandran Plot in PNG Format | ||||||
| Ramz Z Score | -1.31 ±0.29 | |||||
| Residues in Favored Region | 632 | Ramachandran favored | 96.78% | |||
| Number of Outliers | 2 | Ramachandran outliers | 0.31% | |||
| Local Quality |
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| Click to Save Local Quality Plot in PNG Format | ||||||
| QMEANBrane Score | 0.8 | |||||
| AlphaFold Protein Structure Database | ||||||
| SWISS-MODEL Database | ||||||
| Experimental Structures of This DT | ||||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref | |
| 3BXL | X-ray | 2.3 Å | Escherichia coli | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | B | |||||
| Sequence Length | 1867-1887 | Mutation | No | |||
| 7XLQ | EM | 3.1 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 2313 | Mutation | No | |||
| 7YG5 | EM | 3 Å | Homo sapiens | [3] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 2313 | Mutation | No | |||
| 8EPL | EM | 3.1 Å | Homo sapiens | [4] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 2313 | Mutation | No | |||
| 8EPM | EM | 3.1 Å | Homo sapiens | [4] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 2313 | Mutation | Yes | |||
| References | ||||||
| 1 | RCSB PDB: Crystal structure of the CaV2 IQ domain in complex with Ca2+/calmodulin | |||||
| 2 | Molecular insights into the gating mechanisms of voltage-gated calcium channel Ca(V)2.3. Nat Commun. 2023;14(1):516. | |||||
| 3 | Structural insights into the allosteric effects of the antiepileptic drug topiramate on the Ca(V)2.3 channel. Biochem Biophys Res Commun. 2024;725:150271. | |||||
| 4 | Structures of the R-type human Ca(v)2.3 channel reveal conformational crosstalk of the intracellular segments. Nat Commun. 2022;13(1):7358. | |||||
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