Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0520 Transporter Info
Gene Name CACNA1E
Transporter Name Voltage-gated calcium channel alpha Cav2.3
Gene ID
777
UniProt ID
Q15878
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  DT Modulation1

 Valproic Acid affects the expression of CACNA1E mRNA [24]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Valproic Acid results in decreased methylation of CACNA1E gene [25]

Regulation Mechanism

 Transcription Factor Info

  abrine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 abrine results in increased expression of CACNA1E mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  Barium

            4 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 CACNA1E mRNA alternative form results in increased transport of Barium [13]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 CACNA1E protein affects the transport of Barium [14]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 CACNA1E protein results in increased transport of Barium [15]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation4

 SNX 482 inhibits the reaction CACNA1E mRNA alternative form results in increased transport of Barium [13]

Regulation Mechanism

 Transcription Factor Info

  Benzo(a)pyrene

            4 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Benzo(a)pyrene affects the methylation of CACNA1E exon [16]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Benzo(a)pyrene affects the methylation of CACNA1E promoter [16]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Benzo(a)pyrene results in increased methylation of CACNA1E 5' UTR [16]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation4

 Benzo(a)pyrene results in increased mutagenesis of CACNA1E gene [17]

Regulation Mechanism

 Transcription Factor Info

  bisphenol A

            5 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 bisphenol A promotes the reaction Estradiol results in decreased activity of CACNA1E protein binds to CACNB3 protein [18]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 bisphenol A results in decreased activity of CACNA1E protein binds to CACNB3 protein [18]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 bisphenol A results in decreased methylation of CACNA1E gene [19]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation4

 bisphenol A results in increased expression of CACNA1E mRNA [8]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation5

 Estradiol promotes the reaction bisphenol A results in decreased activity of CACNA1E protein binds to CACNB3 protein [18]

Regulation Mechanism

 Transcription Factor Info

  CGP 52608

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 CGP 52608 promotes the reaction RORA protein binds to CACNA1E gene [20]

Regulation Mechanism

 Transcription Factor Info

  Estradiol

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 bisphenol A promotes the reaction Estradiol results in decreased activity of CACNA1E protein binds to CACNB3 protein [18]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Estradiol promotes the reaction bisphenol A results in decreased activity of CACNA1E protein binds to CACNB3 protein [18]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Estradiol results in decreased activity of CACNA1E protein binds to CACNB3 protein [18]

Regulation Mechanism

 Transcription Factor Info

  ethyl-p-hydroxybenzoate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 ethyl-p-hydroxybenzoate results in decreased expression of CACNA1E mRNA [21]

Regulation Mechanism

 Transcription Factor Info

  Niclosamide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Niclosamide results in increased expression of CACNA1E mRNA [22]

Regulation Mechanism

 Transcription Factor Info

  SNX 482

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 SNX 482 inhibits the reaction CACNA1E mRNA alternative form results in increased transport of Barium [13]

Regulation Mechanism

 Transcription Factor Info

  Sodium

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 CACNA1E protein results in increased transport of Sodium [15]

Regulation Mechanism

 Transcription Factor Info

  sodium arsenite

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 sodium arsenite results in increased expression of CACNA1E mRNA [23]

Regulation Mechanism

 Transcription Factor Info

Carcinogen

  Cadmium

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cadmium inhibits the reaction CACNA1E protein results in increased transport of Calcium [15]

Regulation Mechanism

 Transcription Factor Info

  Nickel

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Nickel inhibits the reaction CACNA1E protein results in increased transport of Calcium [15]

Regulation Mechanism

 Transcription Factor Info

Dietary Constituent

  Calcium

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 CACNA1E protein results in increased transport of Calcium [15]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Cadmium inhibits the reaction CACNA1E protein results in increased transport of Calcium [15]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Nickel inhibits the reaction CACNA1E protein results in increased transport of Calcium [15]

Regulation Mechanism

 Transcription Factor Info

Approved Drug

  Menthol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Menthol inhibits the expression of CACNA1E [1]

  Arsenic Trioxide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Arsenic Trioxide increases the expression of CACNA1E [2]

  Valproic Acid

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Valproic Acid increases the expression of CACNA1E [3]

Drug in Phase 2 Trial

  Bisphenol A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Bisphenol A increases the expression of CACNA1E [8]

Drug in Preclinical Test

  (+)-JQ1

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 (+)-JQ1 inhibits the expression of CACNA1E [6]

Discontinued Drug

  TH-9229

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 TH-9229 modulates the activity of CACNA1E [10]

Investigative Drug

  CPU-228

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 CPU-228 modulates the activity of CACNA1E [11]

Natural Product

  Tobacco Smoke Pollution

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Tobacco Smoke Pollution inhibits the expression of CACNA1E [9]

Mycotoxins

  Aflatoxin B1

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Aflatoxin B1 inhibits the expression of CACNA1E [4]

Cyanotoxin

  Cylindrospermopsin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cylindrospermopsin inhibits the expression of CACNA1E [5]

  cylindrospermopsin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 cylindrospermopsin results in decreased expression of CACNA1E mRNA [5]

Regulation Mechanism

 Transcription Factor Info

Health and Environmental Toxicant

  Lead

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Lead affects the expression of CACNA1E [7]
References
1 Repurposing L-Menthol for Systems Medicine and Cancer Therapeutics? L-Menthol Induces Apoptosis through Caspase 10 and by Suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
2 Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
3 Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
4 Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):176-87.
5 Modulation of chromatin remodelling induced by the freshwater cyanotoxin cylindrospermopsin in human intestinal caco-2 cells. PLoS One. 2014 Jun 12;9(6):e99121.
6 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
7 RNA-Seq of Human Neural Progenitor Cells Exposed to Lead (Pb) Reveals Transcriptome Dynamics, Splicing Alterations and Disease Risk Associations. Toxicol Sci. 2017 Sep 1;159(1):251-265.
8 Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
9 Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model. Arch Toxicol. 2021 May;95(5):1739-1761.
10 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008159)
11 Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 534).
12 Integration of transcriptomics, proteomics and metabolomics data to reveal the biological mechanisms of abrin injury in human lung epithelial cells. Toxicol Lett. 2019;312:1-10.
13 Functional coupling between 'R-type' Ca2+ channels and insulin secretion in the insulinoma cell line INS-1. Eur J Biochem. 2001;268(4):1066-75.
14 Auxiliary subunit regulation of high-voltage activated calcium channels expressed in mammalian cells. Eur J Neurosci. 2004;20(1):1-13.
15 Inactivation properties of human recombinant class E calcium channels. J Neurophysiol. 2000;83(2):671-84.
16 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
17 Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014;775-776:48-54.
18 Bisphenol A inhibits voltage-activated Ca(2+) channels in vitro: mechanisms and structural requirements. Mol Pharmacol. 2013;83(2):501-11.
19 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019;11(1):138.
20 Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines. Exp Cell Res. 2017;353(1):6-15.
21 Risk assessment of parabens in a transcriptomics-based in vitro test. Chem Biol Interact. 2023;384:110699.
22 Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023;83(2):181-194.
23 High-Throughput Transcriptomics of Nontumorigenic Breast Cells Exposed to Environmentally Relevant Chemicals. Environ Health Perspect. 2024;132(4):47002.
24 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20.
25 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.

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