Detail Information of Mutation-induced Spatial Variation
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0520 Transporter Info | ||||
| Gene Name | CACNA1E | ||||
| Transporter Name | Voltage-gated calcium channel alpha Cav2.3 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Mutation-induced Structural Variation (MSV) of This DT | |||||
| PDB ID | |||||
| Expression System | Homo sapiens | ||||
| Method | EM | ||||
| Resolution | 3.1 Å | ||||
| Corresponding chain | A | ||||
| Mutation Site(s) | N.A. | [1] | |||
| Structure Details | |||||
| Modeling Method | EM | ||||
| Publication year | 2022 | ||||
| PDB ID | Scanning Method | Resolution | Mutation Sites | Details | Ref |
| 8EPM | EM | 3.1 Å | N.A. | [1] | |
| Structure | |||||
| Expression System | Homo sapiens | ||||
| Corresponding chain | A | ||||
| Sequence Length | 1-2313 | Mutation | Yes | ||
| References | |||||
| 1 | Structures of the R-type human Ca(v)2.3 channel reveal conformational crosstalk of the intracellular segments. Nat Commun. 2022;13(1):7358. | ||||
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