Drug Transporter (DT) Information

General Information of DT
DT ID DTD0461
Gene Name SLC6A9
Protein Name Sodium- and chloride-dependent glycine transporter 1
Gene ID
6536
UniProt ID
P48067
TCDB ID
2.A.22.2.12
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:4XPT_A

Identity:44.803%

Minimized Score:-1450.84 kcal/mol

Detail: Structure Info

Synonyms GCENSG; GlyT-1; GlyT1; SLC6A9; Solute carrier family 6 member 9
DT Family Neurotransmitter:Sodium Symporter (NSS) Family ;
Tissue Specificity Isoform GlyT-1A and isoform GlyT-1B can befound in brain, kidney, pancreas, lung, placenta and liver butisoform GlyT-1C is only found in brain.
Function This transporter can terminate the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals and may play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.
Endogenous Substrate(s) Cl-; Na+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium- and chloride-dependent glycine transporter 1
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium- and chloride-dependent glycine transporter 1
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium- and chloride-dependent glycine transporter 1
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Sodium- and chloride-dependent glycine transporter 1
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium- and chloride-dependent glycine transporter 1
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium- and chloride-dependent glycine transporter 1
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium- and chloride-dependent glycine transporter 1
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

(δ) Xenobiotics-regulated Structural Variability
Xenobiotics-regulated Structural Variability (XSV)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium- and chloride-dependent glycine transporter 1
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium- and chloride-dependent glycine transporter 1
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Glycine
 Approved Drug Info Dietary shortage 5B7Z [1]

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Sarcosine
 Phase 2 Drug Info Schizophrenia 6A20 [2]
References
1 Mutation in SLC6A9 encoding a glycine transporter causes a novel form of non-ketotic hyperglycinemia in humans. Hum Genet. 2016 Nov;135(11):1263-1268.
2 Glycine is taken up through GLYT1 and GLYT2 transporters into mouse spinal cord axon terminals and causes vesicular and carrier-mediated release of its proposed co-transmitter GABA. J Neurochem. 2001 Mar;76(6):1823-32.

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