Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0461 Transporter Info
Gene Name	SLC6A9
Transporter Name	Sodium- and chloride-dependent glycine transporter 1
Gene ID	6536
UniProt ID	P48067

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 8 TF(s) Regulating This DT
ATF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[1]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-3		Transcription Factor Info
Tissue	Bone marrow; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
CEBPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[2]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[3]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Bone
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
CEBPD		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[4]
TF Protein Name	CCAAT/enhancer-binding protein delta		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein delta (CEBPD) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[1]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
FOSL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[3]
TF Protein Name	Fos-related antigen 1		Transcription Factor Info
Tissue	Breast; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 1 (FOSL1) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
MAFF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[4]
TF Protein Name	Transcription factor MafF		Transcription Factor Info
Tissue	Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor MafF (MAFF) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
NFE2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[1]
TF Protein Name	Transcription factor NF-E2 45 kDa subunit		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor NF-E2 45 kDa subunit (NFE2) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
ARNT		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[4]
TF Protein Name	Aryl hydrocarbon receptor nuclear translocator		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Aryl hydrocarbon receptor nuclear translocator (ARNT) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
BHLHE40		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[2]
TF Protein Name	Class E basic helix-loop-helix protein 40		Transcription Factor Info
Tissue	Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
MITF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC6A9 gene in melanoma condition			[5]
TF Protein Name	Microphthalmia-associated transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC6A9 gene in melanoma condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
MYC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC6A9 gene in Burkitt lymphoma condition			[6]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Myc proto-oncogene protein (MYC) has been reported to repress the transcription of SLC6A9 gene in Burkitt lymphoma condition, which leads to a decreased expression of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
TAL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[2]
TF Protein Name	T-cell acute lymphocytic leukemia protein 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Colon; Liver; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	T-cell acute lymphocytic leukemia protein 1 (TAL1) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
TCF12		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[3]
TF Protein Name	Transcription factor 12		Transcription Factor Info
Tissue	Blood; Brain; Embryo; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 12 (TCF12) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
TCF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[4]
TF Protein Name	Transcription factor E2-alpha		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2-alpha (TCF3) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
TFAP2A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[2]
TF Protein Name	Transcription factor AP-2-alpha		Transcription Factor Info
Tissue	Cervix; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2-alpha (TFAP2A) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
TFAP2C		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[3]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast; Cervix; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
AR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC6A9 gene in prostate cancer condition			[7]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the transcription of SLC6A9 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
HNF4A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC6A9 gene in health condition			[8]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC6A9 gene in health condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
NR2F2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[3]
TF Protein Name	COUP transcription factor 2		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	COUP transcription factor 2 (NR2F2) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
GATA1		Click to Show/Hide to Show 3 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC6A9 gene in hematopoiesis condition			[9]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC6A9 gene in hematopoiesis condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
Transcriptional Phenomenon2	Binding to SLC6A9 gene in megakaryocytes condition			[10]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC6A9 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
Transcriptional Phenomenon3	Direct binding to SLC6A9 gene			[1]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Tissue	Blood; Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Erythroid transcription factor (GATA1) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
GATA2		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC6A9 gene in hematopoiesis condition			[9]
TF Protein Name	Endothelial transcription factor GATA-2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Endothelial transcription factor GATA-2 (GATA2) has been reported to activate the transcription of SLC6A9 gene in hematopoiesis condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
Transcriptional Phenomenon2	Direct binding to SLC6A9 gene			[2]
TF Protein Name	Endothelial transcription factor GATA-2		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Endothelial transcription factor GATA-2 (GATA2) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
GATA6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC6A9 gene in gastric cancer condition			[11]
TF Protein Name	Transcription factor GATA-6		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor GATA-6 (GATA6) has been reported to activate the transcription of SLC6A9 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 13 TF(s) Regulating This DT
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[4]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
CTCFL		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[4]
TF Protein Name	Transcriptional repressor CTCFL		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCFL (CTCFL) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
EGR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC6A9 gene in erythroleukemia condition			[12]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC6A9 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
KLF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[3]
TF Protein Name	Krueppel-like factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 1 (KLF1) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
KLF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[4]
TF Protein Name	Krueppel-like factor 4		Transcription Factor Info
Tissue	Breast; Foreskin; Pancreatic ductal; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 4 (KLF4) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
KLF5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[1]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Tissue	Colon; Pancreatic ductal; Stomach
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 5 (KLF5) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
KLF9		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[2]
TF Protein Name	Krueppel-like factor 9		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 9 (KLF9) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[1]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
ZBTB17		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[2]
TF Protein Name	Zinc finger and BTB domain-containing protein 17		Transcription Factor Info
Tissue	Bone
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 17 (ZBTB17) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
ZBTB7A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[3]
TF Protein Name	Zinc finger and BTB domain-containing protein 7A		Transcription Factor Info
Tissue	Bone marrow; Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
ZBTB7B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[4]
TF Protein Name	Zinc finger and BTB domain-containing protein 7B		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 7B (ZBTB7B) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[1]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Bone marrow; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
ZNF384		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[2]
TF Protein Name	Zinc finger protein 384		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 384 (ZNF384) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
DUX4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[4]
TF Protein Name	Double homeobox protein 4		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Double homeobox protein 4 (DUX4) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
PBX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[2]
TF Protein Name	Pre-B-cell leukemia transcription factor 3		Transcription Factor Info
Tissue	Blood; Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 5 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[2]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F1 (E2F1) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[3]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
E2F8		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[1]
TF Protein Name	Transcription factor E2F8		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F8 (E2F8) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
FOXA2		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC6A9 gene in health condition			[8]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of SLC6A9 gene in health condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
Transcriptional Phenomenon2	Direct binding to SLC6A9 gene			[1]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Tissue	Embryo; Liver; Lung; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
FOXP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[3]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein P1 (FOXP1) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 6 TF(s) Regulating This DT
ETS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[4]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Lung; Prostate; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
FLI1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC6A9 gene in megakaryocytes condition			[10]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC6A9 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
Transcriptional Phenomenon2	Direct binding to SLC6A9 gene			[2]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[4]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Bone marrow; Embryo; Liver; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
IRF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[2]
TF Protein Name	Interferon regulatory factor 1		Transcription Factor Info
Tissue	Bone marrow; Pancreatic ductal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Interferon regulatory factor 1 (IRF1) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
MYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[3]
TF Protein Name	Transcriptional activator Myb		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional activator Myb (MYB) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
SPI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[3]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
Class3.7: ARID domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
KDM5B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[1]
TF Protein Name	Lysine-specific demethylase 5B		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Lysine-specific demethylase 5B (KDM5B) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
TF Superclass5: alpha-Helices exposed by beta-structures
Class5.1: MADS box factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SRF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[4]
TF Protein Name	Serum response factor		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Serum response factor (SRF) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
Class5.3: SAND domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GMEB2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[1]
TF Protein Name	Glucocorticoid modulatory element-binding protein 2		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Glucocorticoid modulatory element-binding protein 2 (GMEB2) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
TF Superclass6: Immunoglobulin fold
Class6.2: STAT domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
STAT3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC6A9 gene in glioblastoma multiforme condition			[13]
TF Protein Name	Signal transducer and activator of transcription 3		Transcription Factor Info
Affected Drug/Substrate	Temozolomide
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Signal transducer and activator of transcription 3 (STAT3) has been reported to bind to the transcription of SLC6A9 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold
Class7.1: SMAD/NF-1 DNA-binding domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
NFIC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A9 gene			[1]
TF Protein Name	Nuclear factor 1 C-type		Transcription Factor Info
Tissue	Brain; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear factor 1 C-type (NFIC) can directly bind to the SLC6A9 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent glycine transporter 1.
TF Superclass10: Yet undefined DNA-binding domains
Class10.1: Other factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
HMGN3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC6A9 gene in health condition			[14]
TF Protein Name	High mobility group nucleosome-binding domain-containing protein 3		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Eye
Related DT Changes	Up regulating
Experimental Material	C57BL/6J mice
Detailed Description	High mobility group nucleosome-binding domain-containing protein 3 (HMGN3) has been reported to activate the transcription of SLC6A9 gene in health condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent glycine transporter 1.

References
1	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
3	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
4	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-437. (ID:ENSG00000196517)
5	Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
6	Deep sequencing of MYC DNA-binding sites in Burkitt lymphoma. PLoS One. 2011;6(11):e26837.
7	Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
8	Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
9	Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell. 2009;36(4):667-81.
10	Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
11	Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
12	Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
13	Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
14	Chromosomal proteins HMGN3a and HMGN3b regulate the expression of glycine transporter 1. Mol Cell Biol. 2004 May;24(9):3747-56.

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