Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0461 Transporter Info
Gene Name	SLC6A9
Transporter Name	Sodium- and chloride-dependent glycine transporter 1
Gene ID	6536
UniProt ID	P48067

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Cisplatin co-treated with jinfukang results in increased expression of SLC6A9 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC6A9 intron		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene results in increased expression of SLC6A9 mRNA		[42]
Regulation Mechanism			Transcription Factor Info
1-Butanol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Gasoline co-treated with 1-Butanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in increased expression of SLC6A9 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
8-Bromo Cyclic Adenosine Monophosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SLC6A9 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of SLC6A9 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
adefovir dipivoxil	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	adefovir dipivoxil results in decreased expression of SLC6A9 mRNA		[2]
Regulation Mechanism			Transcription Factor Info
aristolochic acid I	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I results in decreased expression of SLC6A9 mRNA		[40]
Regulation Mechanism			Transcription Factor Info
beta-lapachone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	beta-lapachone results in decreased expression of SLC6A9 mRNA		[43]
Regulation Mechanism			Transcription Factor Info
bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A results in increased expression of SLC6A9 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
Cadmium Chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in decreased expression of SLC6A9 mRNA		[2]
Regulation Mechanism			Transcription Factor Info
chloroacetaldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	chloroacetaldehyde results in decreased expression of SLC6A9 mRNA		[2]
Regulation Mechanism			Transcription Factor Info
Copper	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Disulfiram binds to Copper which results in increased expression of SLC6A9 mRNA		[44]
Regulation Mechanism			Transcription Factor Info
Diazinon	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Diazinon results in increased methylation of SLC6A9 gene		[45]
Regulation Mechanism			Transcription Factor Info
dibenzo(a,l)pyrene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene results in increased expression of SLC6A9 mRNA		[42]
Regulation Mechanism			Transcription Factor Info
Dichlorodiphenyl Dichloroethylene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dichlorodiphenyl Dichloroethylene results in decreased expression of SLC6A9 mRNA		[46]
Regulation Mechanism			Transcription Factor Info
Disulfiram	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Disulfiram binds to Copper which results in increased expression of SLC6A9 mRNA		[44]
Regulation Mechanism			Transcription Factor Info
enniatins	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	enniatins results in increased expression of SLC6A9 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
Estradiol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol co-treated with TGFB1 protein results in decreased expression of SLC6A9 mRNA		[47]
Regulation Mechanism			Transcription Factor Info
Ethanol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Gasoline co-treated with Ethanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in increased expression of SLC6A9 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
ferrous chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ferrous chloride results in decreased expression of SLC6A9 mRNA		[48]
Regulation Mechanism			Transcription Factor Info
Gasoline	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Gasoline co-treated with 1-Butanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in increased expression of SLC6A9 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Gasoline co-treated with Ethanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in increased expression of SLC6A9 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Gasoline results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in increased expression of SLC6A9 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
ICG 001	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ICG 001 results in increased expression of SLC6A9 mRNA		[17]
Regulation Mechanism			Transcription Factor Info
Methamphetamine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC6A9 gene SNP results in increased susceptibility to Methamphetamine		[49]
Regulation Mechanism			Transcription Factor Info
mivebresib	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	mivebresib results in decreased expression of SLC6A9 mRNA		[50]
Regulation Mechanism			Transcription Factor Info
mono-(2-ethylhexyl)phthalate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	mono-(2-ethylhexyl)phthalate results in increased expression of SLC6A9 mRNA		[51]
Regulation Mechanism			Transcription Factor Info
nobiletin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	nobiletin results in increased expression of SLC6A9 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
NSC668394	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NSC668394 results in increased expression of SLC6A9 mRNA		[19]
Regulation Mechanism			Transcription Factor Info
NVP-BKM120	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sotorasib co-treated with trametinib co-treated with NVP-BKM120 results in increased expression of SLC6A9 mRNA		[52]
Regulation Mechanism			Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in increased expression of SLC6A9 mRNA		[53]
Regulation Mechanism			Transcription Factor Info
OTX015	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	OTX015 results in decreased expression of SLC6A9 mRNA		[50]
Regulation Mechanism			Transcription Factor Info
Oxygen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Oxygen deficiency results in decreased expression of SLC6A9 mRNA		[2]
Regulation Mechanism			Transcription Factor Info
perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluorooctane sulfonic acid results in increased expression of SLC6A9 mRNA		[55]
Regulation Mechanism			Transcription Factor Info
perfluorooctanoic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid results in increased expression of SLC6A9 mRNA		[56]
Regulation Mechanism			Transcription Factor Info
S-(1,2-dichlorovinyl)cysteine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	S-(1,2-dichlorovinyl)cysteine results in increased expression of SLC6A9 mRNA		[57]
Regulation Mechanism			Transcription Factor Info
Silicon Dioxide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog results in increased expression of SLC6A9 mRNA		[58]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Silicon Dioxide results in decreased expression of SLC6A9 mRNA		[59]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in decreased expression of SLC6A9 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased expression of SLC6A9 mRNA		[60]
Regulation Mechanism			Transcription Factor Info
Sodium Selenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium Selenite results in increased expression of SLC6A9 mRNA		[61]
Regulation Mechanism			Transcription Factor Info
sotorasib	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sotorasib co-treated with trametinib co-treated with NVP-BKM120 results in increased expression of SLC6A9 mRNA		[52]
Regulation Mechanism			Transcription Factor Info
titanium dioxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	titanium dioxide results in increased expression of SLC6A9 mRNA		[11]
Regulation Mechanism			Transcription Factor Info
trametinib	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sotorasib co-treated with trametinib co-treated with NVP-BKM120 results in increased expression of SLC6A9 mRNA		[52]
Regulation Mechanism			Transcription Factor Info
tris(2-butoxyethyl) phosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tris(2-butoxyethyl) phosphate affects the expression of SLC6A9 mRNA		[62]
Regulation Mechanism			Transcription Factor Info
Vanadium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vanadium results in decreased expression of SLC6A9 mRNA		[12]
Regulation Mechanism			Transcription Factor Info
Mycotoxins
Aflatoxin B1	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 results in increased methylation of SLC6A9 intron		[39]
Regulation Mechanism			Transcription Factor Info
aflatoxin B2	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	aflatoxin B2 results in increased methylation of SLC6A9 intron		[39]
Regulation Mechanism			Transcription Factor Info
Nanoparticle
perfluoro-n-nonanoic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluoro-n-nonanoic acid results in increased expression of SLC6A9 mRNA		[54]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Dexamethasone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dexamethasone inhibits the expression of SLC6A9		[1]
Adefovir dipivoxil	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Adefovir dipivoxil inhibits the expression of SLC6A9		[2]
Cidofovir	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cidofovir inhibits the expression of SLC6A9		[2]
Cisplatin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cisplatin inhibits the expression of SLC6A9		[2]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclosporine increases the expression of SLC6A9		[2]
Fenofibrate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Fenofibrate increases the expression of SLC6A9		[2]
Ibuprofen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ibuprofen increases the expression of SLC6A9		[2]
Ifosfamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ifosfamide inhibits the expression of SLC6A9		[2]
Acetaminophen	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of SLC6A9		[3]
DT Modulation2	Acetaminophen results in increased expression of SLC6A9 mRNA		[38]
Regulation Mechanism			Transcription Factor Info
Rifampin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Rifampin increases the expression of SLC6A9		[4]
Arsenic Trioxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic Trioxide increases the expression of SLC6A9		[5]
Urethane	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Urethane inhibits the expression of SLC6A9		[6]
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Doxorubicin inhibits the expression of SLC6A9		[7]
Cannabidiol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cannabidiol increases the expression of SLC6A9		[9]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sunitinib increases the expression of SLC6A9		[10]
Titanium dioxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Titanium dioxide increases the expression of SLC6A9		[11]
Drug Marketed but not Approved by US FDA
Clodronic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Clodronic Acid inhibits the expression of SLC6A9		[2]
Rotenone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Rotenone inhibits the expression of SLC6A9		[8]
Drug in Phase 3 Trial
R1678	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	R1678 blocks the activity of SLC6A9		[31]
Drug in Phase 2 Trial
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol A increases the expression of SLC6A9		[22]
AMG 747	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	AMG 747 modulates the activity of SLC6A9		[28]
PF-3463275	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	PF-3463275 inhibits the activity of SLC6A9		[28]
ORG-25935	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ORG-25935 inhibits the activity of SLC6A9		[28], [29]
Drug in Phase 1 Trial
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite inhibits the expression of SLC6A9		[24]
ALX 5407	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ALX 5407 blocks the activity of SLC6A9		[26], [27]
MK-2637	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	MK-2637 modulates the activity of SLC6A9		[30]
GlyT1 PET radiotracers	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	GlyT1 PET radiotracers modulates the activity of SLC6A9		[32]
DCCCyB	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	DCCCyB modulates the activity of SLC6A9		[33]
JNJ-17305600	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	JNJ-17305600 inhibits the activity of SLC6A9		[34]
Drug in Preclinical Test
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 inhibits the expression of SLC6A9		[18]
Patented Pharmaceutical Agent
ICG-001	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ICG-001 increases the expression of SLC6A9		[17]
NSC-668394	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NSC-668394 increases the expression of SLC6A9		[19]
Natural Product
Coal Ash	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Coal Ash inhibits the expression of SLC6A9		[12]
Thapsigargin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thapsigargin increases the expression of SLC6A9		[14]
Nobiletin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nobiletin increases the expression of SLC6A9		[15]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the expression of SLC6A9		[21]
Traditional Medicine
Jinfukang	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Jinfukang increases the expression of SLC6A9		[20]
Acute Toxic Substance
Enniatins	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Enniatins increases the expression of SLC6A9		[25]
Carcinogen
Benzo(a)pyrene	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of SLC6A9		[13]
Arsenic	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic affects the methylation of SLC6A9 gene		[41]
Regulation Mechanism			Transcription Factor Info
Pesticide/Insecticide
Endosulfan	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Endosulfan increases the expression of SLC6A9		[23]
Health and Environmental Toxicant
tris(1,3-dichloro-2-propyl)phosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tris(1,3-dichloro-2-propyl)phosphate increases the expression of SLC6A9		[16]

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60	Cellular and Molecular Effects of Prolonged Low-Level Sodium Arsenite Exposure on Human Hepatic HepaRG Cells. Toxicol Sci. 2018 Apr 1;162(2):676-687.
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62	Toxicogenomics of the flame retardant tris (2-butoxyethyl) phosphate in HepG2 cells using RNA-seq. Toxicol In Vitro. 2018;46:178-188.

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