Drug Information

General Information
Drug ID
DR00242
Drug Name
Glycine
Synonyms
(1-13c)glycinato; (15N)Glycine; 2,2-dialkylglycines; 2-Aminoacetic acid; AB-131/40217813; AMINOACETIC ACID 1.5% IN PLASTIC CONTAINER; Acide aminoacetique; Acide aminoacetique [INN-French]; Acido aminoacetico; Acido aminoacetico [INN-Spanish]; Acidum aminoaceticum; Acidum aminoaceticum [INN-Latin]; Aciport; Aminoacetic acid; Aminoazijnzuur; Aminoessigsaeure; Aminoethanoic acid; Amitone; An alpha amino acid ester; Corilin; GLY (IUPAC abbrev); GLYCINE 1.5% IN PLASTIC CONTAINER; GLYCINE, ACS; Glicina; Glicina [INN-Spanish]; Glicoamin; Gly; Glycin; Glycine (JP15/USP); Glycine [INN]; Glycine iron sulphate (1:1); Glycine, homopolymer (VAN); Glycine, labeled with carbon-14; Glycine, non-medical; Glycine-UL-14C hydrochloride; Glycinum; Glycinum [INN-Latin]; Glycocoll; Glycolixir; Glycosthene; Glykokoll; Glyzin; Gyn-hydralin; H-Gly-OH; H2N-CH2-COOH; Hampshire glycine; Hgly; L-Glycine; L-alpha-amino acids; Leimzucker; Padil; Polyglycine; Polyglycine II; S04-0135; Sucre de gelatine
Drug Type
Small molecular drug
Indication Dietary shortage [ICD11:5B7Z] Approved [1]
Therapeutic Class
Dietary supplement
Structure
3D MOL 2D MOL
Formula
C2H5NO2
Canonical SMILES
C(C(=O)O)N
InChI
InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChIKey
DHMQDGOQFOQNFH-UHFFFAOYSA-N
CAS Number
CAS 56-40-6
Pharmaceutical Properties Molecular Weight 75.07 Topological Polar Surface Area 63.3
Heavy Atom Count 5 Rotatable Bond Count 1
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
XLogP
-3.2
PubChem CID
750
PubChem SID
10527483 ,11113413 ,11528254 ,14747327 ,16955354 ,17404564 ,24439112 ,24775647 ,24849510 ,24860042 ,24865701 ,24873323 ,24895210 ,24895217 ,24895290 ,24895306 ,24895353 ,24895355 ,24898980 ,24901611 ,26718882 ,26751653 ,3133349 ,3339 ,33728423 ,37415007 ,46295148 ,585843 ,589752 ,626974 ,6435754 ,7346033 ,7847079 ,7887927 ,7979426 ,8026292 ,8026825 ,8138085 ,8145759 ,8150769 ,827140 ,829229 ,829387 ,830123 ,833865 ,836630 ,836631 ,838484 ,841093 ,86929
ChEBI ID
ChEBI:15428
TTD Drug ID
D0M8AB
DT(s) Transporting This Drug ASCT2 Transporter Info Alanine/serine/cysteine/threonine transporter 2 Substrate [2]
BGT1 Transporter Info Na(+)/Cl(-) betaine/GABA transporter Substrate [3]
GLYT1 Transporter Info Sodium- and chloride-dependent glycine transporter 1 Substrate [4]
GLYT2 Transporter Info Sodium- and chloride-dependent glycine transporter 2 Substrate [5]
LAT2 Transporter Info L-type amino acid transporter 2 Substrate [6]
PAT1 Transporter Info Proton-coupled amino acid transporter 1 Substrate [7]
Drug-Transporter Activity Data
Drug-Transporter Activity Data ASCT2 Transporter Info Km =320 microM HRPE cells-ASCT2 [2]
References
1 Cannabidiol was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+). Am J Physiol Gastrointest Liver Physiol. 2007 Nov;293(5):G1046-53.
3 Interpreting metabolomic profiles using unbiased pathway models. PLoS Comput Biol. 2010 Feb 26;6(2):e1000692.
4 Mutation in SLC6A9 encoding a glycine transporter causes a novel form of non-ketotic hyperglycinemia in humans. Hum Genet. 2016 Nov;135(11):1263-1268.
5 Mutations in the GlyT2 gene (SLC6A5) are a second major cause of startle disease. J Biol Chem. 2012 Aug 17;287(34):28975-85.
6 The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.3.8.20)
7 Transport of amino acids and GABA analogues via the human proton-coupled amino acid transporter, hPAT1: characterization of conditions for affinity and transport experiments in Caco-2 cells. Eur J Pharm Sci. 2008 Sep 2;35(1-2):86-95.

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