Drug Transporter (DT) Information

General Information of DT
DT ID DTD0117
Gene Name SLC17A4
Protein Name Probable small intestine urate exporter
Gene ID
10050
UniProt ID
Q9Y2C5
TCDB ID
2.A.1.14.24
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:6V4D_A

Identity:33.198%

Minimized Score:-924.609 kcal/mol

Detail: Structure Info

Synonyms KAIA2138; SLC17A4; Solute carrier family 17 member 4
DT Family Major Facilitator Superfamily (MFS)
Anion:Cation Symporter (ACS) Family
Tissue Specificity Abundantly expressed in pancreas, liver, colonand small intestine, less in kidney. Not detected in the adrenalglands, brain, placenta, heart, testis, skeletal muscle, andlungs.
Function This membrane potential-dependent organic anion transporter can actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro), and may be involved in urate extrusion from the intestinal duct. And it may recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates.
Endogenous Substrate(s) Na+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Probable small intestine urate exporter
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Probable small intestine urate exporter
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Probable small intestine urate exporter
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Probable small intestine urate exporter
Microbiota Influence (MBI)

(β) Post-translational Modification of Probable small intestine urate exporter
Post-translational Modification (PTM)

(δ) Epigenetic Regulation of Probable small intestine urate exporter
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Probable small intestine urate exporter
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Probable small intestine urate exporter
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Probable small intestine urate exporter
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           5 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Aspirin
 Approved Drug Info Pain MG30-MG7Z [1]
Ibuprofen
 Approved Drug Info Pain MG30-MG7Z [1]
Phosphate
 Approved Drug Info Constipation ME05.0 [1]
Pravastatin
 Approved Drug Info Hypercholesterolemia 5C80.0 [1]
Salicylic acid
 Approved Drug Info Dermatitis EA80-EA8Z [1]

Drug-DT Affinity Assessed by Cell Line

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:           9 Drugs in Total
Drug Name Highest Status Detail Cell Line Affinity Ref
Aminohippuric acid Withdrawn Drug Info E.coli C43 (DE3) cells-hNPT homologue Km =700 microM [1]
Aminohippuric acid Withdrawn Drug Info E.coli C43 (DE3) cells-hNPT homologue Km =700 microM [1]
Aminohippuric acid Withdrawn Drug Info E.coli C43 (DE3) cells-hNPT homologue Km =700 microM [1]
Aminohippuric acid Withdrawn Drug Info E.coli C43 (DE3) cells-hNPT homologue Km =700 microM [1]
Aminohippuric acid Withdrawn Drug Info E.coli C43 (DE3) cells-hNPT homologue Km =700 microM [1]
Aminohippuric acid Withdrawn Drug Info E.coli C43 (DE3) cells-hNPT homologue Km =700 microM [1]
Aminohippuric acid Withdrawn Drug Info E.coli C43 (DE3) cells-hNPT homologue Km =700 microM [1]
Aminohippuric acid Withdrawn Drug Info E.coli C43 (DE3) cells-hNPT homologue Km =700 microM [1]
Aminohippuric acid Withdrawn Drug Info E.coli C43 (DE3) cells-hNPT homologue Km =700 microM [1]
References
1 A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1652-60.

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