Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00556
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| Drug Name |
Salicylic acid
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| Synonyms |
2 Hydroxybenzoic Acid; 2-Carboxyphenol; 2-Hydroxybenzenecarboxylic acid; 2-Hydroxybenzoic acid; 2-hydroxy(1-14c)benzoic acid; ALPHA/BETA HYDROXY ACIDS (SALICYLIC ACID) (SEE ALPHA/BETA HYDROXY ACIDS); ATA fraction 10, ammonium salt; Acid, 2-Hydroxybenzoic; Acid, Salicylic; Acid, o-Hydroxybenzoic; Acid, ortho-Hydroxybenzoic; Acido o-idrossibenzoico; Acido o-idrossibenzoico [Italian]; Acido salicilico; Acido salicilico [Italian]; Acidum salicylicum; Advanced pain relief callus removers; Advanced pain relief corn removers; Akurza Cream; Akurza Lotion; Alpha/Beta Hydroxy Acids (Glycolic Acid, Salicylic Acid); BENZOIC ACID,2-HYDROXY SALICYLIC ACID; Benzoic acid, 2-hydroxy-(9CI); CMC_13852; Clear away wart remover; DHS Sal Shampoo; Domerine; Dr. Scholl's callus removers; Dr. Scholl's corn removers; Dr. Scholl's wart remover kit; DuoPlant Gel; Duofil wart remover; Duofilm; Duoplant; E9A559BE-383B-4F83-BC02-3031D03D558A; Freezone; Hydrisalic Gel; Ionil; Ionil plus; Ionil-Plus; K 537; Keralyt; Kyselina 2-hydroxybenzoova; Kyselina 2-hydroxybenzoova [Czech]; Kyselina salicylova; Kyselina salicylova [Czech]; Mediplast pads; O Hydroxybenzoic Acid; O-Carboxyphenol; O-hydroxybenzoic acid; Occlusal; Ortho Hydroxybenzoic Acid; Ortho-Hydroxybenzoic Acid; Orthohydroxybenzoic acid; P&S Shampoo; Phenol derivative, 7; Phenol-2-carboxylic acid; Propa pH Peel-Off Acne Mask; Psoriacid-S-stift; Retarder SAX; Retarder W; Rutranex; SALICYLIC ACID (SEE ALSO ALPHA HYDROXY ACIDS); SALICYLIC ACID, ACS; SAX; Salex Cream; Salex Lotion; Salicylate; Salicylic acid; Salicylic acid & Sulfur Soap; Salicylic acid (6CI,8CI); Salicylic acid (JP15/USP); Salicylic acid (TN); Salicylic acid [USAN:JAN]; Salicylic acid collodion; Salicylic acid soap; Salicylic acid, tech; Salicylic acid, tech.; Salicylic acid-ring-UL-14C; Saligel; Salonil; Sebucare; Sebulex; Stri-Dex; Trans-Ver-Sal; Verrugon
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| Drug Type |
Small molecular drug
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| Indication | Acne vulgaris [ICD11:ED80] | Approved | [1] | |||
| Dermatitis [ICD11:EA80-EA8Z] | Approved | [1] | ||||
| Therapeutic Class |
Antiinflammatory Agents
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C7H6O3
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| Canonical SMILES |
C1=CC=C(C(=C1)C(=O)O)O
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| InChI |
InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)
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| InChIKey |
YGSDEFSMJLZEOE-UHFFFAOYSA-N
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| CAS Number |
CAS 69-72-7
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| Pharmaceutical Properties | Molecular Weight | 138.12 | Topological Polar Surface Area | 57.5 | ||
| Heavy Atom Count | 10 | Rotatable Bond Count | 1 | |||
| Hydrogen Bond Donor Count | 2 | Hydrogen Bond Acceptor Count | 3 | |||
| XLogP |
2.3
|
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| PubChem CID | ||||||
| PubChem SID |
10318573
,10533161
,11335476
,11360715
,11363842
,11366404
,11368966
,11377128
,11461687
,11494762
,14747739
,17435988
,17435989
,22391538
,24438713
,24715046
,24846714
,24854876
,24856524
,24888186
,24899681
,24899745
,24899797
,24901960
,26512236
,26736241
,26754507
,29215390
,29497303
,3135021
,33247984
,4063
,46487944
,587978
,602430
,6435737
,67116
,7694870
,7847165
,7890372
,7980555
,8139912
,8145741
,8150584
,819755
,819897
,823464
,826329
,841486
,854399
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| ChEBI ID |
ChEBI:16914
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | MCT1 | Transporter Info | Monocarboxylate transporter 1 | Substrate | [2] | |
| MCT2 | Transporter Info | Monocarboxylate transporter 2 | Substrate | [3] | ||
| SLC17A4 | Transporter Info | Probable small intestine urate exporter | Substrate | [4] | ||
| SMCT2 | Transporter Info | Sodium-coupled monocarboxylate transporter 2 | Substrate | [5] | ||
| References | ||||||
| 1 | Salicylic acid was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | H+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine. Exp Physiol. 2007 Jul;92(4):603-19. | |||||
| 3 | Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy. Clin Transl Sci. 2018 Jul;11(4):352-364. | |||||
| 4 | A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1652-60. | |||||
| 5 | Sodium-coupled monocarboxylate transporters in normal tissues and in cancer. AAPS J. 2008;10(1):193-9. | |||||
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