Detail Information of Microbiota Influence
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0117 Transporter Info | ||||
| Gene Name | SLC17A4 | ||||
| Transporter Name | Probable small intestine urate exporter | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Microbiota Influence of This DT (MBI) | |||||
|---|---|---|---|---|---|
|
Bacteria: Host unspecified microbiota | |||||
|
Genus: Unknown microbiota |
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|
Host unspecified microbiota |
Click to Show/Hide the Full List 1 Microbe Influence Related to This Species |
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|
Microbe Influence1 |
Down regulating of SLC17A4 expression in clostridium difficile infection condition | [1] | |||
|
Regulating Factor |
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|
Studied Phenotype |
Colitis [ICD11: 1A40.0] | ||||
|
In Vitro Model |
HT29 cells | ||||
|
Detailed Description |
The metabolite urolithin A generated from the metabolism of dietary precursors by the host unspecified microbiota has been reported to downregulate the expression of the drug transporter SLC17A4. | ||||
| References | |||||
|---|---|---|---|---|---|
| 1 | Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway. Nat Commun. 2019 Jan 9;10(1):89. | ||||
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