Drug Information

General Information
Drug ID
DR00132
Drug Name
Phosphate
Synonyms
14265-44-2; AC1L1AN2; AKOS015903596; BDBM50155537; CHEBI:18367; CREATINE PHOSPHATE; CTK0H5978; DTXSID7039672; I14-18227; N-PHOSPHOCREATINE; NBIIXXVUZAFLBC-UHFFFAOYSA-K; NK08V8K8HR; O-Phosphate; Orthophosphate; PO4; PO4(3-); Phosphate ion; Phosphate ions; Phosphates; Phosphoric acid trianion; UNII-NK08V8K8HR; [PO4](3-); a phosphate group; phosphoric acid, ion(3-); tetraoxidophosphate(3-); tetraoxophosphate(3-); tetraoxophosphate(V)
Drug Type
Small molecular drug
Indication Constipation [ICD11:ME05.0] Approved [1]
Structure
3D MOL 2D MOL
Formula
O4P-3
Canonical SMILES
[O-]P(=O)([O-])[O-]
InChI
InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKey
NBIIXXVUZAFLBC-UHFFFAOYSA-K
CAS Number
CAS 14265-44-2
Pharmaceutical Properties Molecular Weight 94.971 Topological Polar Surface Area 86.2
Heavy Atom Count 5 Rotatable Bond Count 0
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 4
XLogP
-2.3
PubChem CID
1061
PubChem SID
103066731 ,103077071 ,104042950 ,104075345 ,104296651 ,125331104 ,125823182 ,126524047 ,134989311 ,135292823 ,137001640 ,142051012 ,14709385 ,152043015 ,15218698 ,163304750 ,175268694 ,176264609 ,176270178 ,223741247 ,24439414 ,3071 ,53787703 ,56310835 ,56311388 ,57320705 ,7728230 ,7889982 ,79295108 ,8144764 ,8150953 ,840917 ,841057
ChEBI ID
CHEBI:18367
TTD Drug ID
D08VYC
DT(s) Transporting This Drug DIC Transporter Info Mitochondrial dicarboxylate carrier Substrate [2]
G3PP Transporter Info Glycerol-3-phosphate permease Substrate [3]
NPT1 Transporter Info Sodium-dependent phosphate transport protein 1 Substrate [4]
NPT4 Transporter Info Sodium-dependent phosphate transport protein 4 Substrate [5]
PHC Transporter Info Phosphate carrier protein Substrate [6]
PIT1 Transporter Info Sodium-dependent phosphate transporter 1 Substrate [7]
PIT2 Transporter Info Sodium-dependent phosphate transporter 2 Substrate [7]
SCAMC1 Transporter Info Calcium-binding mitochondrial carrier protein SCaMC-1 Substrate [8]
SCAMC2 Transporter Info Calcium-binding mitochondrial carrier protein SCaMC-2 Substrate [9]
SCAMC3 Transporter Info Calcium-binding mitochondrial carrier protein SCaMC-3 Substrate [10]
SLC17A4 Transporter Info Probable small intestine urate exporter Substrate [11]
VGLUT1 Transporter Info Vesicular glutamate transporter 1 Substrate [12]
VGLUT2 Transporter Info Vesicular glutamate transporter 2 Substrate [4]
References
1 Phosphate was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 SLC25A10 biallelic mutations in intractable epileptic encephalopathy with complex I deficiency. Hum Mol Genet. 2018 Feb 1;27(3):499-504.
3 SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. PLoS One. 2011;6(9):e23157.
4 Type 1 sodium-dependent phosphate transporter (SLC17A1 Protein) is a Cl(-)-dependent urate exporter. J Biol Chem. 2010 Aug 20;285(34):26107-13.
5 Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. J Biol Chem. 2010 Nov 5;285(45):35123-32.
6 The mammalian phosphate carrier SLC25A3 is a mitochondrial copper transporter required for cytochrome c oxidase biogenesis. J Biol Chem. 2018 Feb 9;293(6):1887-1896.
7 Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50.
8 De Novo Mutations in SLC25A24 Cause a Disorder Characterized by Early Aging, Bone Dysplasia, Characteristic Face, and Early Demise. Am J Hum Genet. 2017 Nov 2;101(5):844-855.
9 Ketogenic diet induces expression of the muscle circadian gene Slc25a25 via neural pathway that might be involved in muscle thermogenesis. Sci Rep. 2017 Jun 6;7(1):2885.
10 Cellular expression and alternative splicing of SLC25A23, a member of the mitochondrial Ca2+-dependent solute carrier gene family. Gene. 2005 Jan 31;345(2):173-82.
11 A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1652-60.
12 SLC17: a functionally diverse family of organic anion transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):350-9.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.