Drug Transporter (DT) Information

General Information of DT
DT ID DTD0137
Gene Name SLC20A2
Protein Name Sodium-dependent phosphate transporter 2
Gene ID
6575
UniProt ID
Q08357
TCDB ID
2.A.20.2.3
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms GLVR-2; GLVR2; Gibbon ape leukemia virus receptor 2; IBGC1; IBGC3; MLVAR; Phosphate transporter 2; PiT-2; Pit2; RAM1; Ram-1; SLC20A2; Solute carrier family 20 member 2; hPit2
DT Family Inorganic Phosphate Transporter (PIT) Family ;
Tissue Specificity Ubiquitously expressed.
Function This sodium-phosphate transporter mediates phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants.
Endogenous Substrate(s) Na+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium-dependent phosphate transporter 2
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium-dependent phosphate transporter 2
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium-dependent phosphate transporter 2
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Sodium-dependent phosphate transporter 2
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium-dependent phosphate transporter 2
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium-dependent phosphate transporter 2
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium-dependent phosphate transporter 2
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium-dependent phosphate transporter 2
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium-dependent phosphate transporter 2
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Phosphate
 Approved Drug Info Constipation ME05.0 [1]
References
1 Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50.

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