Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0137 Transporter Info
Gene Name	SLC20A2
Transporter Name	Sodium-dependent phosphate transporter 2
Gene ID	6575
UniProt ID	Q08357

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC20A2 5' UTR		[27]
Regulation Mechanism			Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC20A2 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
Acrolein	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in increased expression of SLC20A2 mRNA		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in increased expression of SLC20A2 mRNA		[23]
Regulation Mechanism			Transcription Factor Info
alpha-pinene	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in increased expression of SLC20A2 mRNA		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in increased expression of SLC20A2 mRNA		[23]
Regulation Mechanism			Transcription Factor Info
benzo(e)pyrene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	benzo(e)pyrene results in increased methylation of SLC20A2 intron		[25]
Regulation Mechanism			Transcription Factor Info
beta-lapachone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	beta-lapachone results in increased expression of SLC20A2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
bisphenol A	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A results in decreased methylation of SLC20A2 gene		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	bisphenol A results in increased expression of SLC20A2 mRNA		[19]
Regulation Mechanism			Transcription Factor Info
bisphenol F	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol F co-treated with Fulvestrant results in increased methylation of SLC20A2 gene		[29]
Regulation Mechanism			Transcription Factor Info
bisphenol S	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol S results in increased methylation of SLC20A2 gene		[29]
Regulation Mechanism			Transcription Factor Info
Choline	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Choline promotes the reaction SLC20A2 protein results in increased uptake of Phosphates		[31]
Regulation Mechanism			Transcription Factor Info
coumarin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	coumarin results in decreased phosphorylation of SLC20A2 protein		[30]
Regulation Mechanism			Transcription Factor Info
dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	dicrotophos results in increased expression of SLC20A2 mRNA		[16]
Regulation Mechanism			Transcription Factor Info
dorsomorphin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC20A2 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
Foscarnet	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Foscarnet inhibits the reaction Phosphates results in increased expression of SLC20A2 mRNA		[14]
Regulation Mechanism			Transcription Factor Info
FR900359	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	FR900359 affects the phosphorylation of SLC20A2 protein		[32]
Regulation Mechanism			Transcription Factor Info
Fulvestrant	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol F co-treated with Fulvestrant results in increased methylation of SLC20A2 gene		[29]
Regulation Mechanism			Transcription Factor Info
Lithium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Lithium promotes the reaction SLC20A2 protein results in increased uptake of Phosphates		[31]
Regulation Mechanism			Transcription Factor Info
methacrylaldehyde	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in increased expression of SLC20A2 mRNA		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in increased expression of SLC20A2 mRNA		[23]
Regulation Mechanism			Transcription Factor Info
Methapyrilene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methapyrilene results in increased methylation of SLC20A2 intron		[25]
Regulation Mechanism			Transcription Factor Info
Ozone	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in increased expression of SLC20A2 mRNA		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in increased expression of SLC20A2 mRNA		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Ozone results in decreased expression of SLC20A2 mRNA		[33]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Volatile Organic Compounds co-treated with Ozone results in increased expression of SLC20A2 mRNA		[23]
Regulation Mechanism			Transcription Factor Info
Phenylmercuric Acetate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC20A2 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
Phosphates	6 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Choline promotes the reaction SLC20A2 protein results in increased uptake of Phosphates		[31]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Foscarnet inhibits the reaction Phosphates results in increased expression of SLC20A2 mRNA		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Lithium promotes the reaction SLC20A2 protein results in increased uptake of Phosphates		[31]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Phosphates results in increased expression of SLC20A2 mRNA		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	SLC20A2 protein results in increased uptake of Phosphates		[31]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	Sodium promotes the reaction SLC20A2 protein results in increased uptake of Phosphates		[31]
Regulation Mechanism			Transcription Factor Info
Silver	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Silver results in increased expression of SLC20A2 mRNA		[17]
Regulation Mechanism			Transcription Factor Info
Sodium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium promotes the reaction SLC20A2 protein results in increased uptake of Phosphates		[31]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased expression of SLC20A2 mRNA		[12]
Regulation Mechanism			Transcription Factor Info
Tetrachlorodibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tetrachlorodibenzodioxin results in increased expression of SLC20A2 mRNA		[13]
Regulation Mechanism			Transcription Factor Info
triphenyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	triphenyl phosphate affects the expression of SLC20A2 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
Valproic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid results in increased methylation of SLC20A2 gene		[35]
Regulation Mechanism			Transcription Factor Info
Vitamin K 3	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vitamin K 3 affects the expression of SLC20A2 mRNA		[2]
Regulation Mechanism			Transcription Factor Info
Mycotoxins
Aflatoxin B1	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 results in decreased methylation of SLC20A2 gene		[24]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Aflatoxin B1 results in increased methylation of SLC20A2 intron		[25]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate increases the expression of SLC20A2		[1]
Menadione	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Menadione affects the expression of SLC20A2		[2]
Zidovudine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zidovudine increases the expression of SLC20A2		[3]
Rifampin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Rifampin inhibits the expression of SLC20A2		[4]
Urethane	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Urethane inhibits the expression of SLC20A2		[5]
Leflunomide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Leflunomide increases the expression of SLC20A2		[6]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sunitinib inhibits the expression of SLC20A2		[7]
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tretinoin inhibits the expression of SLC20A2		[8]
Testosterone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Testosterone increases the expression of SLC20A2		[9]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of SLC20A2		[10]
Phosphonoformate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phosphonoformate inhibits the activity of SLC20A2		[11]
Drug in Phase 3 Trial
Triclosan	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Triclosan inhibits the expression of SLC20A2		[18]
Drug in Phase 2 Trial
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol A increases the expression of SLC20A2		[19]
Drug in Phase 1 Trial
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite increases the expression of SLC20A2		[12]
Investigative Drug
Phosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phosphate increases the expression of SLC20A2		[14]
Natural Product
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution increases the expression of SLC20A2		[20]
Caffeine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Caffeine affects the phosphorylation of SLC20A2 protein		[30]
Regulation Mechanism			Transcription Factor Info
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin increases the expression of SLC20A2		[13]
Acute Toxic Substance
Cadmium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium increases the expression of SLC20A2		[15]
Carcinogen
Benzo(a)pyrene	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of SLC20A2		[21]
Arsenic	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic affects the methylation of SLC20A2 gene		[26]
Regulation Mechanism			Transcription Factor Info
Pesticide/Insecticide
Dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dicrotophos increases the expression of SLC20A2		[16]
Nanoparticle
Silver nanoparticle	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Silver nanoparticle increases the expression of SLC20A2		[17]

References
1	Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
2	Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203.
3	Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23.
4	Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
5	Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
6	Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
7	Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761.
8	Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423.
9	The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384.
10	Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
11	Inflammatory Effects of Nitrogen-Containing Bisphosphonates (N-BPs): Modulation by Non-N-BPs. Biol Pharm Bull. 2017;40(1):25-33.
12	Exit from arsenite-induced mitotic arrest is p53 dependent. Environ Health Perspect. 2006 Sep;114(9):1401-6.
13	Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
14	High expression of the Pi-transporter SLC20A1/Pit1 in calcific aortic valve disease promotes mineralization through regulation of Akt-1. PLoS One. 2013;8(1):e53393.
15	Short and long term gene expression variation and networking in human proximal tubule cells when exposed to cadmium. BMC Med Genomics. 2013;6 Suppl 1(Suppl 1):S2.
16	Molecular mechanisms of discrotophos-induced toxicity in HepG2 cells: The role of CSA in oxidative stress. Food Chem Toxicol. 2017 May;103:253-260.
17	Altered global gene expression profiles in human gastrointestinal epithelial Caco2 cells exposed to nanosilver. Toxicol Rep. 2016 Jan 22;3:262-268.
18	Transcriptome and DNA Methylome Dynamics during Triclosan-Induced Cardiomyocyte Differentiation Toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
19	Involvement of the Endocrine-Disrupting Chemical Bisphenol A (BPA) in Human Placentation. J Clin Med. 2020 Feb 3;9(2):405.
20	Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model. Arch Toxicol. 2021 May;95(5):1739-1761.
21	Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297.
22	Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
23	Post-transcriptional air pollution oxidation to the cholesterol biosynthesis pathway promotes pulmonary stress phenotypes. Commun Biol. 2020;3(1):392.
24	Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma. Toxicology. 2016 Mar 28;350-352:31-9.
25	Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018;121:214-223.
26	Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106.
27	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
28	Lapachone induces ferroptosis of colorectal cancer cells via NCOA4-mediated ferritinophagy by activating JNK pathway. Chem Biol Interact. 2024;389:110866.
29	DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019;11(1):138.
30	Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022;449:116110.
31	Deciphering PiT transport kinetics and substrate specificity using electrophysiology and flux measurements. Am J Physiol Cell Physiol. 2007;293(2):C606-20.
32	Protein Kinase Signaling Networks Driven by Oncogenic Gq/11 in Uveal Melanoma Identified by Phosphoproteomic and Bioinformatic Analyses. Mol Cell Proteomics. 2023;22(11):100649.
33	Individuals with increased inflammatory response to ozone demonstrate muted signaling of immune cell trafficking pathways. Respir Res. 2012;13(1):89.
34	Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60-69 Years of Age: Evidence from the China BAPE Study. Environ Health Perspect. 2023;131(4):47009.
35	Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.

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Detail Information of Exogenous Modulation

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