Drug Transporter (DT) Information

General Information of DT
DT ID DTD0184
Gene Name SLC25A23
Protein Name Calcium-binding mitochondrial carrier protein SCaMC-3
Gene ID
79085
UniProt ID
Q9BV35
TCDB ID
2.A.29.23.5
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:4N5X_A; 4C9G_A

Identity:50.556%;28.214%

Minimized Score:-904.406 kcal/mol

Detail: Structure Info

Synonyms APC2; MCSC2; Mitochondrial ATP-Mg/Pi carrier protein 2; Mitochondrial Ca(2+)-dependent solute carrier protein 2; SCAMC3; SCaMC-3; SLC25A23; Small calcium-binding mitochondrial carrier protein 3; Solute carrier family 25 member 23
DT Family Mitochondrial Carrier (MC) Family ;
Tissue Specificity Present in various cell lines (at proteinlevel). Expressed at low levels in most tissues examined, withhighest expression in brain, skeletal muscle and pancreas.
Function This calcium-dependent mitochondrial solute carrier may act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria, and it shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane.
Endogenous Substrate(s) Nucleotides; Cofactors; Adenine nucleotides
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Calcium-binding mitochondrial carrier protein SCaMC-3
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Calcium-binding mitochondrial carrier protein SCaMC-3
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Calcium-binding mitochondrial carrier protein SCaMC-3
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Calcium-binding mitochondrial carrier protein SCaMC-3
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Calcium-binding mitochondrial carrier protein SCaMC-3
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Calcium-binding mitochondrial carrier protein SCaMC-3
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Calcium-binding mitochondrial carrier protein SCaMC-3
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Calcium-binding mitochondrial carrier protein SCaMC-3
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Calcium-binding mitochondrial carrier protein SCaMC-3
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Phosphate
 Approved Drug Info Constipation ME05.0 [1]
References
1 Cellular expression and alternative splicing of SLC25A23, a member of the mitochondrial Ca2+-dependent solute carrier gene family. Gene. 2005 Jan 31;345(2):173-82.

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