Drug Information

General Information
Drug ID
DR00663
Drug Name
Ibuprofen
Synonyms
ACHES-N-PAIN; Act-3; Act-3 (TN); Actiprofen; Adex 200; Adran; Advil; Advil (TN); Ak+C2278tren; Aktre (TN); Alaxan; Alaxan (TN); Algofen; Algoflex (TN); Alivium (TN); Am-Fam 400; Amelior; Amersol; Amibufen; Anafen; Anco; Andran; Anflagen; Antagil; Antalfene; Antarene; Antiflam; Apsifen; Apsifen-F; Arthrofen (TN); Artofen; Artril; Artril 300; Balkaprofen; Betaprofen; Bloom; Bluton; Bonifen (TN); Brofen; Brufanic; Brufen; Brufen (TN); Brufen 400; Bruflam; Brufort; Buburone; Bufeno; Bufigen; Bugesic (TN); Bukrefen; Bupron; Buracaps; Burana; Burana (TN); Butylenin; Caldolor (TN); Calprofen (TN); Cap-Profen; Carol;Cesra; Citalgan; Cobo; Codral; Combiflam; Cunil; DOLO PUREN; Daiprophen; Dalsy; Dalsy (TN); Dansida; Deep Relief; Dentigoa; Dibufen; Dignoflex; Dismenol (TN); Diverin (TN); Dolgirid; Dolgit; Dolgit (TN); Dolibu; Dolmaral; Dolo-Dolgit; Dolo-Spedifen (TN); Dolocyl; Dolofen; Dolofen-F; Dolofin; Dolofort; Dolofort (TN); Dologel; Dolomax; Doloraz (TN); Doloren; Dolormin; Dolormin (TN); Doltibil; Dolven; Donjust B; Dorival; Dorival (TN); Drin; Duafen; Duobrus; Dura-Ibu; Dysdolen; Easifon; Ebufac; Ebufac (TN); Emflam; Emflam-200; EmuProfen (TN); Epobron; Eputex; Ergix; Espidifen (TN); Esprenit; Eve (TN); Exneural; Faspic; Femadon; Femafen; Femapirin; Femidol; Fenbid (TN); Fenbid;Fendol; Fenpaed (TN); Fenspan; Fibraflex; Finalflex (TN); Galprofen (TN); Gelufene; Gofen; Grefen; Gynofug; Haltran; Hedex (TN); Herron Blue (TN); I 4883; I-profen (TN); IB-100; IBU-Ratiopharm (TN); IBUFEN (TN); IP 82; IP-82; IP82; Ibalgin (TN); Ibol; Ibren; Ibu; Ibu-Attritin; Ibu-Tab; Ibu-Tab 200; Ibu-Vivimed (TN); Ibu-slo; Ibu-slow; IbuHEXAL (TN); Ibubest; Ibubeta; Ibucasen; Ibudol; Ibudolor; Ibufen; Ibuflamar; Ibufug; Ibugel; Ibugel (TN); Ibugen; Ibugesic; Ibuhexal; Ibulagic; Ibular; Ibulav; Ibuleve; Ibuleve (TN); Ibulgan; Ibum (TN); Ibumax (TN); Ibumed; Ibumerck; Ibumetin; Ibumetin (TN); Ibupirac; Ibuprin; Ibuprocin; Ibuprofene; Ibuprofeno; Ibuprofenum; Ibuprohm; Ibuprom (TN); Ibuprophen; Ibuprosyn (TN); Ibusal; Ibutid; Ibux (TN); Ibuxin (TN); Ifen; Inabrin; Inflam; Inoven; Ipren; Ipren (TN); Irfen; Isodol; Jenaprofen; Junifen; Kesan; Kratalgin; Kratalgin (TN); Lamidon; Lebrufen; Librofem; Lidifen; Liptan; Lopane; Malafene; Manypren; Medicol (TN); Medipren; Melfen; Mensoton; Midol; Midol 200; Moment; Moment (TN); Motrin; Motrin (TN); Motrin IB; Mynosedin; Nagifen-D; Napacetin; Narfen; Narfen (TN); Neo-Helvagit; Neo-Mindol; Neobrufen; Neobrufen (TN); Neofen (TN); Nerofen; Noalgil; Nobafon; Nobfelon; Nobfen; Nobgen; Noritis; Norton; Norvectan (TN); Novadol; Novo-Profen; Novogent; Novogent N; Novoprofen; Nuprilan; Nuprin; Nuprin (TN); Nureflex (TN); Nurofen; Nurofen (TN); Optifen; Opturem; Oralfene; Orbifen (TN); Ostarin; Ostofen; Ozonol; Paduden; Panafen; Panafen (TN); Pantrop; Paxofen; Pedia-Profen; PediaProfen; Perifar (TN); Perofen; Proartinal; Profen; Profin (TN); Proflex; Provon; Quadrax; R.D. 13621; RD 13621; Rafen; Ranofen; Ratiodolor (TN); Rebugen; Relcofen; Retard (TN); Rhinadvil; Rimafen (TN); Rofen; Roidenin; Rufen; Rufin; Rupan; Sadefen; Salivia; Salprofen; Salvarina (TN); Seclodin; Sednafen; Seklodin; Seskafen; Siyafen; Solpaflex; Solpaflex (TN); Solufen; Spedifen (TN); Speedpain NANO (TN); Spidifen (TN); Stelar; Sugafen; Suprafen; Suspren; Syntofene; Tab-Profen; Tabalon; Tabalon 400; Tatanal; Tempil; Tofen; Togal N; Tonal; Trendar; U 18573; U-18,573; U-18573; UCB 79171; Unipron; Upfen; Upfen (TN); Uprofen; Urem; VUFB 9649; Zafen; Zofen
Drug Type
Small molecular drug
Indication Pain [ICD11:MG30-MG7Z] Approved [1]
Therapeutic Class
Analgesics
Structure
3D MOL 2D MOL
Formula
C13H18O2
Canonical SMILES
CC(C)CC1=CC=C(C=C1)C(C)C(=O)O
InChI
InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
InChIKey
HEFNNWSXXWATRW-UHFFFAOYSA-N
CAS Number
CAS 15687-27-1
Pharmaceutical Properties Molecular Weight 206.28 Topological Polar Surface Area 37.3
Heavy Atom Count 15 Rotatable Bond Count 4
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
XLogP
3.5
PubChem CID
3672
PubChem SID
10509306 ,11152950 ,11336062 ,11361301 ,11363743 ,11366305 ,11368867 ,11371490 ,11373528 ,11377029 ,11406458 ,11462273 ,11483914 ,11487945 ,11490281 ,11491830 ,11494663 ,138460 ,14822381 ,17405252 ,24277715 ,24896130 ,25623341 ,26611780 ,26679534 ,26747223 ,26747224 ,26752326 ,26758921 ,29222795 ,3140375 ,46507255 ,47217047 ,4743 ,47515579 ,47885643 ,47959999 ,48413891 ,48416098 ,49761821 ,49831178 ,611158 ,7647311 ,7847194 ,7979568 ,8062120 ,8147017 ,8149384 ,8152318 ,855602
ChEBI ID
ChEBI:5855
TTD Drug ID
D0R1QE
DT(s) Transporting This Drug MCT2 Transporter Info Monocarboxylate transporter 2 Substrate [2]
SLC17A4 Transporter Info Probable small intestine urate exporter Substrate [3]
References
1 Ibuprofen was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 Monocarboxylate Transporters in Drug Disposition: Role in the Toxicokinetics and Toxicodynamics of the Drug of Abuse GHB.
3 A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1652-60.

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