Drug Transporter (DT) Information

General Information of DT
DT ID DTD0500
Gene Name SLCO2A1
Protein Name Organic anion transporting polypeptide 2A1
Gene ID
6578
UniProt ID
Q92959
TCDB ID
2.A.60.1.19
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms MATR1; OATP2A1; PGT; PHOAR2; Prostaglandin transporter; SLC21A2; SLCO2A1; Solute carrier family 21 member 2; Solute carrier organic anion transporter family member 2A1
DT Family Organo Anion Transporter (OAT) Family ;
Tissue Specificity Ubiquitous. Significant expression observed inling, kidney, spleen, and heart.
Function This transporter may mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.
Disease(s) Medical abortion [ICD-11:JA00.1]
Open angle glaucoma [ICD-11:9C61]
Pulmonary arterial hypertension [ICD-11:BB01.0]
Endogenous Substrate(s) Organoanions
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Organic anion transporting polypeptide 2A1
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Organic anion transporting polypeptide 2A1
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Organic anion transporting polypeptide 2A1
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Organic anion transporting polypeptide 2A1
Microbiota Influence (MBI)

(β) Post-translational Modification of Organic anion transporting polypeptide 2A1
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Organic anion transporting polypeptide 2A1
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Organic anion transporting polypeptide 2A1
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Organic anion transporting polypeptide 2A1
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Organic anion transporting polypeptide 2A1
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Organic anion transporting polypeptide 2A1
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           4 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Alprostadil
 Approved Drug Info Erectile dysfunction HA01 [1]
Dinoprostone
 Approved Drug Info Medical abortion JA00.1 [2]
Iloprost
 Approved Drug Info Pulmonary arterial hypertension BB01.0 [1]
Latanoprost
 Approved Drug Info Open angle glaucoma 9C61 [3]

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Prostaglandin f2Alpha
 Preclinical Drug Info Solid tumours 2D4Z [1]

Endogenous Metabolites (EMs) Handled by This DT

 Endogenous Metabolites (EMs)

 Click to Show/Hide the Full List of EMs:           2 EMs in Total
EM Name PubChem CID Detail Experimental Material Ref
Prostaglandin E2
5280360
EM Info Identified using thiazide-induced hyponatremia patients SLCO2A1 396 Ala/Thr/Glu variants [4]
Tetranor-prostaglandin EM
161468
EM Info Identified using thiazide-induced hyponatremia patients SLCO2A1 396 Ala/Thr/Glu variants [4]
References
1 Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT). J Clin Invest. 1996 Sep 1;98(5):1142-9.
2 Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60.
3 The prostaglandin transporter OATP2A1 is expressed in human ocular tissues and transports the antiglaucoma prostanoid latanoprost. Invest Ophthalmol Vis Sci. 2010 May;51(5):2504-11.
4 Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia. J Clin Invest. 2017 Sep 1;127(9):3367-3374.

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