Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0500 Transporter Info
Gene Name SLCO2A1
Transporter Name Organic anion transporting polypeptide 2A1
Gene ID
6578
UniProt ID
Q92959

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        BACH1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO2A1 gene in breast cancer bone metastasis condition [1]

TF Protein Name

 Transcription regulator protein BACH1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription regulator protein BACH1 (BACH1) has been reported to activate the transcription of SLCO2A1 gene in breast cancer bone metastasis condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 2A1.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2A1 gene [2]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Embryo; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLCO2A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2A1.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        AHR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO2A1 gene in breast cancer condition [3]

TF Protein Name

 Aryl hydrocarbon receptor Transcription Factor Info

Affected Drug/Substrate

 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Aryl hydrocarbon receptor (AHR) has been reported to activate the transcription of SLCO2A1 gene in breast cancer condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 2A1.

        ARNT 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO2A1 gene in breast cancer condition [3]

TF Protein Name

 Aryl hydrocarbon receptor nuclear translocator Transcription Factor Info

Affected Drug/Substrate

 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Aryl hydrocarbon receptor nuclear translocator (ARNT) has been reported to activate the transcription of SLCO2A1 gene in breast cancer condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 2A1.

        TCF12 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2A1 gene [4]

TF Protein Name

 Transcription factor 12 Transcription Factor Info

Tissue

 Blood; Brain; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor 12 (TCF12) can directly bind to the SLCO2A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2A1.

        TCF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2A1 gene [5]

TF Protein Name

 Transcription factor E2-alpha Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2-alpha (TCF3) can directly bind to the SLCO2A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2A1.

        TCF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO2A1 gene in glioblastoma multiforme condition [6]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to bind to the transcription of SLCO2A1 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 2A1.

      Class1.3: Basic helix-span-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TFAP2C 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2A1 gene [7]

TF Protein Name

 Transcription factor AP-2 gamma Transcription Factor Info

Tissue

 Breast; Cervix; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLCO2A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2A1.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 7 TF(s) Regulating This DT

        AR 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO2A1 gene in prostate cancer condition [8]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLCO2A1 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 2A1.

       Transcriptional Phenomenon2

 Direct binding to SLCO2A1 gene [7]

TF Protein Name

 Androgen receptor Transcription Factor Info

Tissue

 Breast; Cervix; Kidney; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Androgen receptor (AR) can directly bind to the SLCO2A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2A1.

        ESR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2A1 gene in breast cancer condition [9]

TF Protein Name

 Estrogen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Estrogen receptor (ESR1) has been reported to bind to the SLCO2A1 gene in breast cancer condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 2A1.

        ESR2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO2A1 gene in breast cancer condition [9]

TF Protein Name

 Estrogen receptor beta Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Estrogen receptor beta (ESR2) has been reported to bind to the transcription of SLCO2A1 gene in breast cancer condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 2A1.

        NR1I2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO2A1 gene in head and neck squamous cell carcinoma condition [10]

TF Protein Name

 Nuclear receptor subfamily 1 group I member 2 Transcription Factor Info

Studied Phenotype

 Head and neck squamous cell carcinoma [2D60.0]

Tissue

 Head and neck

Related DT Changes

 up regulating

Experimental Material

 Human head and neck squamous cell carcinoma isolates

Detailed Description

 Nuclear receptor subfamily 1 group I member 2 (NR1I2), influenced by the exogenous decitabine, has been reported to activate the transcription of SLCO2A1 gene in head and neck squamous cell carcinoma condition , which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 2A1.

        NR2F2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2A1 gene [2]

TF Protein Name

 COUP transcription factor 2 Transcription Factor Info

Tissue

 Bone marrow; Breast; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 COUP transcription factor 2 (NR2F2) can directly bind to the SLCO2A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2A1.

        PPARA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLCO2A1 gene in health condition [11]

TF Protein Name

 Peroxisome proliferator-activated receptor alpha Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Liver

Related DT Changes

 Down regulating

Experimental Material

 C57BL/6 mice

Detailed Description

 Peroxisome proliferator-activated receptor alpha (PPARA) has been reported to repress the transcription of SLCO2A1 gene in health condition, which leads to a decreased expression of the drug transporter Organic anion transporting polypeptide 2A1.

        PPARG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO2A1 gene in health condition [12]

TF Protein Name

 Peroxisome proliferator-activated receptor gamma Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Trophoderm

Related DT Changes

 up regulating

Experimental Material

 Pig conceptus trophoblast cells

Detailed Description

 Peroxisome proliferator-activated receptor gamma (PPARG), influenced by the exogenous rosiglitazone, has been reported to activate the transcription of SLCO2A1 gene in health condition , which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 2A1.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        GATA3 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO2A1 gene in breast cancer condition [13]

TF Protein Name

 Trans-acting T-cell-specific transcription factor GATA-3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) has been reported to bind to the transcription of SLCO2A1 gene in breast cancer condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 2A1.

       Transcriptional Phenomenon2

 Direct binding to SLCO2A1 gene [4]

TF Protein Name

 Trans-acting T-cell-specific transcription factor GATA-3 Transcription Factor Info

Tissue

 Blood; Brain; Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) can directly bind to the SLCO2A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2A1.

        GATA4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO2A1 gene in gastric cancer condition [14]

TF Protein Name

 Transcription factor GATA-4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor GATA-4 (GATA4) has been reported to activate the transcription of SLCO2A1 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 2A1.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2A1 gene [2]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Striated muscle

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the SLCO2A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2A1.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2A1 gene [5]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLCO2A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2A1.

        ZNF217 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO2A1 gene in breast cancer condition [15]

TF Protein Name

 Zinc finger protein 217 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Zinc finger protein 217 (ZNF217) has been reported to bind to the transcription of SLCO2A1 gene in breast cancer condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 2A1.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2A1 gene [4]

TF Protein Name

 Zinc finger protein 263 Transcription Factor Info

Tissue

 Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 263 (ZNF263) can directly bind to the SLCO2A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2A1.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        PBX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO2A1 gene in ovarian cancer condition [16]

TF Protein Name

 Pre-B-cell leukemia transcription factor 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Pre-B-cell leukemia transcription factor 1 (PBX1) has been reported to activate the transcription of SLCO2A1 gene in ovarian cancer condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 2A1.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        E2F6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2A1 gene [7]

TF Protein Name

 Transcription factor E2F6 Transcription Factor Info

Tissue

 Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F6 (E2F6) can directly bind to the SLCO2A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2A1.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO2A1 gene [17]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of SLCO2A1 gene in . condition, which leads to a affected expression of the drug transporter Organic anion transporting polypeptide 2A1.

        FOXP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2A1 gene [5]

TF Protein Name

 Forkhead box protein P1 Transcription Factor Info

Tissue

 Embryo; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Forkhead box protein P1 (FOXP1) can directly bind to the SLCO2A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2A1.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        FLI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2A1 gene [4]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLCO2A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2A1.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2A1 gene [7]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Embryo; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLCO2A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2A1.

      Class3.6: TEA domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TEAD4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2A1 gene [2]

TF Protein Name

 Transcriptional enhancer factor TEF-3 Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional enhancer factor TEF-3 (TEAD4) can directly bind to the SLCO2A1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2A1.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SMAD4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO2A1 gene in hESCs condition [18]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of SLCO2A1 gene in human embryonic stem cells (hESCs) condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 2A1.
References
1 Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis. J Biol Chem. 2012;287(40):33533-44.
2 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
3 High-resolution genome-wide mapping of AHR and ARNT binding sites by ChIP-Seq. Toxicol Sci. 2012 Dec;130(2):349-61.
4 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
5 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
6 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
7 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-404. (ID:ENSG00000174640)
8 Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor. Oncotarget. 2012;3(2):183-94.
9 Global analysis of estrogen receptor beta binding to breast cancer cell genome reveals an extensive interplay with estrogen receptor alpha for target gene regulation. BMC Genomics. 2011;12:36.
10 Transporter gene expression in human head and neck squamous cell carcinoma and associated epigenetic regulatory mechanisms. Am J Pathol. 2013 Jan;182(1):234-43.
11 Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways. Drug Metab Dispos. 2005 Sep;33(9):1276-82.
12 Peroxisome proliferator-activated receptor beta/delta and gamma agonists differentially affect prostaglandin E2 and cytokine synthesis and nutrient transporter expression in porcine trophoblast cells during implantation. Theriogenology. 2020 Aug;152:36-46.
13 Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover. BMC Cancer. 2014;14:278.
14 Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
15 Global analysis of ZNF217 chromatin occupancy in the breast cancer cell genome reveals an association with ERalpha. BMC Genomics. 2014;15(1):520.
16 Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites. PLoS One. 2012;7(5):e36054.
17 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
18 Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol. 2011;357(2):492-504.

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