Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0500 Transporter Info
Gene Name	SLCO2A1
Transporter Name	Organic anion transporting polypeptide 2A1
Gene ID	6578
UniProt ID	Q92959

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Nanoparticle
perfluoro-n-nonanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluoro-n-nonanoic acid results in increased expression of SLCO2A1 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Latanoprost	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Latanoprost inhibits the transportation of Prostaglandin E2 by SLCO2A1 (Ki > 10 microM)			[1]
Affected Drug/Substrate	Prostaglandin E2	Modulation Type	Inhibition
Cell System	Human cervical cancer cell line (Hela)-OATP2A1
DT Modulation2	Latanoprost inhibits the activity of SLCO2A1			[2]
Rosiglitazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rosiglitazone increases the expression of SLCO2A1			[3]
Regulation Mechanism	via enhancement of Peroxisome proliferator-activated receptor gamma (PPARG)			Transcription Factor Info
Cell System	Pig conceptus trophoblast cells
Decitabine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Decitabine increases the expression of SLCO2A1			[4]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Cell System	Human head and neck squamous cell carcinoma isolates
Fluorouracil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluorouracil affects the expression of SLCO2A1			[5]
Methotrexate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methotrexate inhibits the expression of SLCO2A1			[6]
Phenobarbital	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenobarbital increases the expression of SLCO2A1			[7]
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tretinoin increases the expression of SLCO2A1			[8]
Estradiol	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol increases the expression of SLCO2A1			[9]
Nicotine polacrilex	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nicotine polacrilex increases the expression of SLCO2A1			[10]
Zidovudine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zidovudine inhibits the expression of SLCO2A1			[11]
Zoledronic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zoledronic Acid increases the expression of SLCO2A1			[12]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of SLCO2A1			[13]
Arsenic	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arsenic inhibits the expression of SLCO2A1			[14]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sunitinib increases the expression of SLCO2A1			[15]
Drug in Phase 3 Trial
Resveratrol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Resveratrol increases the expression of SLCO2A1			[16]
Triclosan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Triclosan inhibits the expression of SLCO2A1			[21]
Sulforafan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulforafan inhibits the expression of SLCO2A1			[23]
Drug in Phase 2 Trial
Genistein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Genistein increases the expression of SLCO2A1			[9]
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol A increases the expression of SLCO2A1			[26]
Drug in Phase 1 Trial
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite increases the expression of SLCO2A1			[28]
Drug in Preclinical Test
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 inhibits the expression of SLCO2A1			[19]
Investigative Drug
Bromsulphthalein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bromsulphthalein inhibits the activity of SLCO2A1			[29]
Natural Product
Tobacco tar	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco tar inhibits the expression of SLCO2A1			[17]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the expression of SLCO2A1			[27]
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLCO2A1 protein results in increased uptake of Quercetin			[45]
Regulation Mechanism				Transcription Factor Info
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin increases the expression of SLCO2A1			[18]
Bisphenol F	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol F increases the expression of SLCO2A1			[26]
Mycotoxins
Aflatoxin B1	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 increases the expression of SLCO2A1			[24]
DT Modulation2	Aflatoxin B1 results in decreased methylation of SLCO2A1 intron			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Aflatoxin B1 results in increased methylation of SLCO2A1 gene			[31]
Regulation Mechanism				Transcription Factor Info
Carcinogen
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in decreased expression of SLCO2A1 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic which results in decreased expression of SLCO2A1 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
Benzo(a)pyrene	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene increases the expression of SLCO2A1			[24]
Health and Environmental Toxicant
Diethylhexyl Phthalate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diethylhexyl Phthalate increases the expression of SLCO2A1			[22]
Perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Perfluorooctane sulfonic acid increases the expression of SLCO2A1			[25]
Chemical Compound
DT Modulation1	Rifampin inhibits the reaction Decitabine results in increased expression of SLCO2A1 mRNA			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Estradiol binds to ESR2 protein which results in increased expression of SLCO2A1 mRNA			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Estradiol co-treated with Progesterone results in decreased expression of SLCO2A1 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Estradiol co-treated with TGFB1 protein results in increased expression of SLCO2A1 mRNA			[41]
Regulation Mechanism				Transcription Factor Info
Tungsten	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tungsten inhibits the expression of SLCO2A1			[20]
DT Modulation1	Benzo(a)pyrene affects the methylation of SLCO2A1 intron			[30]
Regulation Mechanism				Transcription Factor Info
aristolochic acid I	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I results in decreased expression of SLCO2A1 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
Arsenicals	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arsenicals results in decreased expression of SLCO2A1 mRNA			[14]
Regulation Mechanism				Transcription Factor Info
bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A results in increased expression of SLCO2A1 mRNA			[16]
Regulation Mechanism				Transcription Factor Info
bisphenol F	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol F results in increased expression of SLCO2A1 mRNA			[26]
Regulation Mechanism				Transcription Factor Info
bisphenol S	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol S results in increased expression of SLCO2A1 mRNA			[26]
Regulation Mechanism				Transcription Factor Info
bufotalin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bufotalin results in decreased expression of SLCO2A1 mRNA			[34]
Regulation Mechanism				Transcription Factor Info
cupric chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cupric chloride results in decreased expression of SLCO2A1 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
Diazinon	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diazinon results in increased methylation of SLCO2A1 gene			[36]
Regulation Mechanism				Transcription Factor Info
Diclofenac	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diclofenac inhibits the reaction SLCO2A1 protein results in increased transport of Dinoprostone			[37]
Regulation Mechanism				Transcription Factor Info
Dinoprostone	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diclofenac inhibits the reaction SLCO2A1 protein results in increased transport of Dinoprostone			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Indomethacin promotes the reaction SLCO2A1 protein results in increased transport of Dinoprostone			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Ketoprofen promotes the reaction SLCO2A1 protein results in increased transport of Dinoprostone			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	lumiracoxib inhibits the reaction SLCO2A1 protein results in increased transport of Dinoprostone			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Naproxen promotes the reaction SLCO2A1 protein results in increased transport of Dinoprostone			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	SLCO2A1 protein results in increased transport of Dinoprostone			[37]
Regulation Mechanism				Transcription Factor Info
Esketamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Esketamine results in decreased expression of SLCO2A1 mRNA			[38]
Regulation Mechanism				Transcription Factor Info
ethyl-p-hydroxybenzoate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ethyl-p-hydroxybenzoate results in increased expression of SLCO2A1 mRNA			[42]
Regulation Mechanism				Transcription Factor Info
Indomethacin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indomethacin promotes the reaction SLCO2A1 protein results in increased transport of Dinoprostone			[37]
Regulation Mechanism				Transcription Factor Info
Ketoprofen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ketoprofen promotes the reaction SLCO2A1 protein results in increased transport of Dinoprostone			[37]
Regulation Mechanism				Transcription Factor Info
lead acetate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	lead acetate results in decreased expression of SLCO2A1 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
lumiracoxib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	lumiracoxib inhibits the reaction SLCO2A1 protein results in increased transport of Dinoprostone			[37]
Regulation Mechanism				Transcription Factor Info
Manganese	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in decreased expression of SLCO2A1 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
manganese chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in decreased expression of SLCO2A1 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
Mifepristone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mifepristone promotes the reaction Progesterone affects the expression of SLCO2A1 mRNA			[43]
Regulation Mechanism				Transcription Factor Info
Naproxen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Naproxen promotes the reaction SLCO2A1 protein results in increased transport of Dinoprostone			[37]
Regulation Mechanism				Transcription Factor Info
Nicotine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nicotine results in increased expression of SLCO2A1 mRNA			[10]
Regulation Mechanism				Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in increased expression of SLCO2A1 mRNA			[44]
Regulation Mechanism				Transcription Factor Info
o,p'-DDT	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	o,p'-DDT results in increased expression of SLCO2A1 mRNA			[16]
Regulation Mechanism				Transcription Factor Info
perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctane sulfonic acid results in increased expression of SLCO2A1 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
perfluorooctanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid results in increased expression of SLCO2A1 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
Progesterone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol co-treated with Progesterone results in decreased expression of SLCO2A1 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Mifepristone promotes the reaction Progesterone affects the expression of SLCO2A1 mRNA			[43]
Regulation Mechanism				Transcription Factor Info
Rifampin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifampin inhibits the reaction Decitabine results in increased expression of SLCO2A1 mRNA			[4]
Regulation Mechanism				Transcription Factor Info
sodium arsenite	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in decreased expression of SLCO2A1 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	sodium arsenite results in decreased methylation of SLCO2A1 exon			[46]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in decreased expression of SLCO2A1 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	sodium arsenite results in increased abundance of Arsenic which results in decreased expression of SLCO2A1 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	sodium arsenite results in increased expression of SLCO2A1 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
sulforaphane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sulforaphane results in decreased expression of SLCO2A1 mRNA			[23]
Regulation Mechanism				Transcription Factor Info
Tetrachlorodibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrachlorodibenzodioxin results in increased expression of SLCO2A1 mRNA			[18]
Regulation Mechanism				Transcription Factor Info
Thiram	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thiram results in decreased expression of SLCO2A1 mRNA			[35]
Regulation Mechanism				Transcription Factor Info

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Detail Information of Exogenous Modulation

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