General Information of Drug Transporter (DT)
DT ID	DTD0500 Transporter Info
Gene Name	SLCO2A1
Protein Name	Organic anion transporting polypeptide 2A1
Gene ID	6578
UniProt ID	Q92959
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs34550074
Site of GPD	chr3:133947365 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	C>G / C>T
Minor Allele Frequency	T=0.2837/1421 (Global)
Allele T	Click to Show/Hide the Full List of Affected Drugs:           3 Drugs in Total
Thiazides, Plain	N.A.	Hyponatremia	Allele T is associated with increased likelihood of Hyponatremia when treated with Thiazides, plain in people with Hypertension as compared to allele C.		[ 1]
Thiazides, Plain	N.A.	Hypertension	Allele T is associated with increased likelihood of Hyponatremia when treated with Thiazides, plain in people with Hypertension as compared to allele C.		[ 1]
Thiazides	N.A.	Hypertension	Correlated with the increased likelihood of hyponatremia in patients (compare with allele C)		[ 1]
Genotype CC	Click to Show/Hide the Full List of Affected Drugs:           2 Drugs in Total
Thiazides, Plain	N.A.	Hypertension	Patients with hypertension and the CC genotype who are administered thiazides may have a decreased likelihood of hyponatremia as compared to patients with the CT or TT genotypes. Other clinical and genetic factors may also influence likelihood of hyponatremia in patients with hypertension who are administered thiazides.		[ 1]
Thiazides, Plain	N.A.	Hyponatremia	Patients with hypertension and the CC genotype who are administered thiazides may have a decreased likelihood of hyponatremia as compared to patients with the CT or TT genotypes. Other clinical and genetic factors may also influence likelihood of hyponatremia in patients with hypertension who are administered thiazides.		[ 1]
Genotype CT	Click to Show/Hide the Full List of Affected Drugs:           2 Drugs in Total
Thiazides, Plain	N.A.	Hypertension	Patients with hypertension and the CT genotype who are administered thiazides may have a decreased likelihood of hyponatremia as compared to patients with the TT genotypes and an increased likelihood as compared to patients with the CC genotype. Other clinical and genetic factors may also influence likelihood of hyponatremia in patients with hypertension who are administered thiazides.		[ 1]
Thiazides, Plain	N.A.	Hyponatremia	Patients with hypertension and the CT genotype who are administered thiazides may have a decreased likelihood of hyponatremia as compared to patients with the TT genotypes and an increased likelihood as compared to patients with the CC genotype. Other clinical and genetic factors may also influence likelihood of hyponatremia in patients with hypertension who are administered thiazides.		[ 1]
Genotype TT	Click to Show/Hide the Full List of Affected Drugs:           2 Drugs in Total
Thiazides, Plain	N.A.	Hypertension	Patients with hypertension and the TT genotype who are administered thiazides may have an increased likelihood of hyponatremia as compared to patients with the CT or CC genotypes. Other clinical and genetic factors may also influence likelihood of hyponatremia in patients with hypertension who are administered thiazides.		[ 1]
Thiazides, Plain	N.A.	Hyponatremia	Patients with hypertension and the TT genotype who are administered thiazides may have an increased likelihood of hyponatremia as compared to patients with the CT or CC genotypes. Other clinical and genetic factors may also influence likelihood of hyponatremia in patients with hypertension who are administered thiazides.		[ 1]
References
1	Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia. J Clin Invest. 2017 Sep 1;127(9):3367-3374.

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