Drug Transporter (DT) Information

General Information of DT
DT ID DTD0071
Gene Name ABCG1
Protein Name ATP-binding cassette sub-family G member 1
Gene ID
9619
UniProt ID
P45844
TCDB ID
3.A.1.204.12
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:6ETI_A

Identity:30.957%

Minimized Score:-1183.878 kcal/mol

Detail: Structure Info

Synonyms ABC8; ABCG1; ATP-binding cassette transporter 8; WHITE1; WHT1; White protein homolog
DT Family ATP-Binding Cassette (ABC) Superfamily
Eye Pigment Precursor Transporter (EPP) Family (ABCG)
Tissue Specificity Expressed in several tissues. Expressed inmacrophages; expression is increased in macrophages from patientswith Tangier disease.
Function This transporter involved in macrophage lipid homeostasis and is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes.
Endogenous Substrate(s) Lipids
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of ATP-binding cassette sub-family G member 1
Tissue Distribution Level (TD)

(β) Cell Distribution Level of ATP-binding cassette sub-family G member 1
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of ATP-binding cassette sub-family G member 1
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of ATP-binding cassette sub-family G member 1
Microbiota Influence (MBI)

(β) Post-translational Modification of ATP-binding cassette sub-family G member 1
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of ATP-binding cassette sub-family G member 1
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of ATP-binding cassette sub-family G member 1
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of ATP-binding cassette sub-family G member 1
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(α) Mutation-induced Structural Variation
Mutation-induced Structural Variation (MSV)

General Variability Data of This DT

(α) Genetic Polymorphisms of ATP-binding cassette sub-family G member 1
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of ATP-binding cassette sub-family G member 1
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:         10 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Atorvastatin
 Approved Drug Info Hyperlipidaemia 5C8Z [1]
Cisplatin
 Approved Drug Info Testicular cancer 2C80 [2]
Doxorubicin
 Approved Drug Info Leukemia 2A60-2B33 [3]
Etoposide
 Approved Drug Info Testicular cancer 2C80 [3]
Methotrexate
 Approved Drug Info Leukemia 2A60-2B33 [4]
Oxaliplatin
 Approved Drug Info Colorectal cancer 2B91 [2]
Phenylephrine
 Approved Drug Info Juvenile rheumatoid arthritis FA24 [5]
Simvastatin
 Approved Drug Info Hypercholesterolemia 5C80.0 [1]
Lapatinib Ditosylate
 Phase 4 Drug Info Breast cancer 2C60-2C6Z [7]
Oxycodone Hydrochloride
 Phase 4 Drug Info Chronic pain MG30 [8]

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Cholesterol
 Phase 2 Drug Info Cone-Rod dystrophy 9B70 [6]
References
1 HMG-CoA reductase inhibitors, simvastatin and atorvastatin, downregulate ABCG1-mediated cholesterol efflux in human macrophages. J Cardiovasc Pharmacol. 2013 Jul;62(1):90-8.
2 The role of ATP-binding cassette subfamily G member 1 in tumor progression. Cancer Med. 2024 Jun;13(12):e7285.
3 ABCG1 and Pgp identify drug resistant, self-renewing osteosarcoma cells. Cancer Lett. 2019 Jul 1;453:142-157.
4 Up-regulation of ABCG1 is associated with methotrexate resistance in acute lymphoblastic leukemia cells. Front Pharmacol. 2024 Jan 8;14:1331687.
5 SMC Abca1 and Abcg1 Deficiency Enhances Urinary Bladder Distension but Not Atherosclerosis. Circ Res. 2025 Feb 28;136(5):491-507.
6 Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses. Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):139-43.
7 FDA approval package document
8 Induction of xenobiotic receptors, transporters, and drug metabolizing enzymes by oxycodone. Drug Metab Dispos. 2013 May;41(5):1060-9.

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