Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0071 Transporter Info
Gene Name	ABCG1
Transporter Name	ATP-binding cassette sub-family G member 1
Gene ID	9619
UniProt ID	P45844

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 10 TF(s) Regulating This DT
ATF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[1]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-1		Transcription Factor Info
Tissue	Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-dependent transcription factor ATF-1 (ATF1) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
ATF3		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of ABCG1 gene in glioblastoma multiforme condition			[2]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Cyclic AMP-dependent transcription factor ATF-3 (ATF3) has been reported to repress the transcription of ABCG1 gene in glioblastoma multiforme condition, which leads to a decreased expression of the drug transporter ATP-binding cassette sub-family G member 1.
Transcriptional Phenomenon2	Direct binding to ABCG1 gene			[3]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-3		Transcription Factor Info
Tissue	Bone marrow; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
BACH2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[3]
TF Protein Name	Transcription regulator protein BACH2		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription regulator protein BACH2 (BACH2) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
CEBPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[4]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[5]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
FOSL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[4]
TF Protein Name	Fos-related antigen 1		Transcription Factor Info
Tissue	Breast; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 1 (FOSL1) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
JUN		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene in Coronary artery disease condition			[6]
TF Protein Name	Transcription factor Jun		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor Jun (JUN) has been reported to bind to the ABCG1 gene in coronary artery disease condition, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
JUND		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[5]
TF Protein Name	Transcription factor JunD		Transcription Factor Info
Tissue	Cervix; Colon; Coronary artery; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor JunD (JUND) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
MAFF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[1]
TF Protein Name	Transcription factor MafF		Transcription Factor Info
Tissue	Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor MafF (MAFF) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
MAFK		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[3]
TF Protein Name	Transcription factor MafK		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Embryo; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor MafK (MAFK) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 5 TF(s) Regulating This DT
ASCL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[5]
TF Protein Name	Achaete-scute homolog 1		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Achaete-scute homolog 1 (ASCL1) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
MYOD1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[1]
TF Protein Name	Myoblast determination protein 1		Transcription Factor Info
Tissue	Myotube
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myoblast determination protein 1 (MYOD1) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
TCF12		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[4]
TF Protein Name	Transcription factor 12		Transcription Factor Info
Tissue	Blood; Embryo; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 12 (TCF12) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
TCF21		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene in Coronary Artery Disease condition			[6]
TF Protein Name	Transcription factor 21		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor 21 (TCF21) has been reported to bind to the ABCG1 gene in Coronary Artery Disease condition, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
TCF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[5]
TF Protein Name	Transcription factor E2-alpha		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2-alpha (TCF3) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
TFAP2A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[7]
TF Protein Name	Transcription factor AP-2-alpha		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Transcription factor AP-2-alpha (TFAP2A) has been reported to bind to the transcription of ABCG1 gene in . condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family G member 1.
TFAP2C		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[4]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast; Cervix
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
NR1H2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG1 gene in pregnancy condition			[8]
TF Protein Name	Oxysterols receptor LXR-beta		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Pregnancy [ICD11: JA00-JA2Z]
Tissue	Placenta
Related DT Changes	Up regulating
Experimental Material	human placentas cell isolates
Detailed Description	Oxysterols receptor LXR-beta (NR1H2) has been reported to activate the transcription of ABCG1 gene in pregnancy condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family G member 1.
NR1H3		Click to Show/Hide to Show 7 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG1 gene in atherosclerosis condition			[9]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Atherosclerosis [ICD11: BD40]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	C57BL/6J mice
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of ABCG1 gene in atherosclerosis condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family G member 1.
Transcriptional Phenomenon2	Activation of ABCG1 gene in pregnancy condition			[8]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Pregnancy [ICD11: JA00-JA2Z]
Tissue	Placenta
Related DT Changes	Up regulating
Experimental Material	human placentas cell isolates
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of ABCG1 gene in pregnancy condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family G member 1.
Transcriptional Phenomenon3	Activation of ABCG1 gene in atherosclerotic foam cells condition			[10]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Affected Drug/Substrate	T0901317
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of ABCG1 gene in atherosclerotic foam cells condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family G member 1.
Transcriptional Phenomenon4	Activation of ABCG1 gene in health condition
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of ABCG1 gene in health condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family G member 1.
Transcriptional Phenomenon5	Activation of ABCG1 gene in obesity condition			[11]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Studied Phenotype	Obesity [ICD11: 5B81]
Tissue	White adipose tissue
Related DT Changes	Up regulating
Experimental Material	C57BL/6 mice
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of ABCG1 gene in obesity condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family G member 1.
Transcriptional Phenomenon6	Activation of ABCG1 gene in hepatocellular carcinoma condition			[12]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Studied Phenotype	Hepatocellular carcinoma [ICD11: 2C12.02]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	Human adult hepatocellular carcinoma cells (Huh7)
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of ABCG1 gene in hepatocellular carcinoma condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family G member 1.
Transcriptional Phenomenon7	Activation of ABCG1 gene in health condition			[13]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Skin
Related DT Changes	Up regulating
Experimental Material	C57BL/6 mice
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of ABCG1 gene in health condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family G member 1.
NR2F2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[4]
TF Protein Name	COUP transcription factor 2		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	COUP transcription factor 2 (NR2F2) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
PPARG		Click to Show/Hide to Show 4 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG1 gene in atherosclerosis condition			[14]
TF Protein Name	Peroxisome proliferator-activated receptor gamma		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Atherosclerosis [ICD11: BD40]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	C57BL/6J mice
Detailed Description	Peroxisome proliferator-activated receptor gamma (PPARG) has been reported to activate the transcription of ABCG1 gene in atherosclerosis condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family G member 1.
Transcriptional Phenomenon2	Activation of ABCG1 gene in pulmonary alveolar proteinosis condition			[15]
TF Protein Name	Peroxisome proliferator-activated receptor gamma		Transcription Factor Info
Studied Phenotype	Pulmonary alveolar proteinosis [ICD11: CB04.31]
Tissue	Lung
Related DT Changes	Up regulating
Experimental Material	Human alveolar macrophages isolates
Detailed Description	Peroxisome proliferator-activated receptor gamma (PPARG) has been reported to activate the transcription of ABCG1 gene in pulmonary alveolar proteinosis condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family G member 1.
Transcriptional Phenomenon3	Activation of ABCG1 gene in health condition			[16]
TF Protein Name	Peroxisome proliferator-activated receptor gamma		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Lung
Related DT Changes	up regulating
Experimental Material	C57BL/6J alveolar macrophages
Detailed Description	Peroxisome proliferator-activated receptor gamma (PPARG), influenced by the exogenous rosiglitazone, has been reported to activate the transcription of ABCG1 gene in health condition , which leads to an increased expression of the drug transporter ATP-binding cassette sub-family G member 1.
Transcriptional Phenomenon4	Activation of ABCG1 gene in health condition			[17]
TF Protein Name	Peroxisome proliferator-activated receptor gamma		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	human leukocyte isolates
Detailed Description	Peroxisome proliferator-activated receptor gamma (PPARG) has been reported to activate the transcription of ABCG1 gene in health condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family G member 1.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GATA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCG1 gene in megakaryocytes condition			[18]
TF Protein Name	Endothelial transcription factor GATA-2		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Endothelial transcription factor GATA-2 (GATA2) has been reported to bind to the transcription of ABCG1 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family G member 1.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 9 TF(s) Regulating This DT
BCL6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG1 gene in health condition			[19]
TF Protein Name	B-cell lymphoma 6 protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	B-cell lymphoma 6 protein (BCL6) has been reported to activate the transcription of ABCG1 gene in health condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family G member 1.
EGR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCG1 gene in erythroleukemia condition			[20]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Early growth response protein 1 (EGR1) has been reported to bind to the transcription of ABCG1 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family G member 1.
KLF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[4]
TF Protein Name	Krueppel-like factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 1 (KLF1) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
KLF9		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[3]
TF Protein Name	Krueppel-like factor 9		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 9 (KLF9) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[5]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
WT1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG1 gene in podocyte condition			[21]
TF Protein Name	Wilms tumor protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Wilms tumor protein (WT1) has been reported to activate the transcription of ABCG1 gene in podocyte condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family G member 1.
ZBTB7A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[1]
TF Protein Name	Zinc finger and BTB domain-containing protein 7A		Transcription Factor Info
Tissue	Bone marrow; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
ZNF202		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of ABCG1 gene in hepatoblastoma condition			[22]
TF Protein Name	Zinc finger protein 202		Transcription Factor Info
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	Down regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Zinc finger protein 202 (ZNF202) has been reported to repress the transcription of ABCG1 gene in hepatoblastoma condition, which leads to a decreased expression of the drug transporter ATP-binding cassette sub-family G member 1.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[5]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Bone marrow; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
DUX4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[3]
TF Protein Name	Double homeobox protein 4		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Double homeobox protein 4 (DUX4) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
HOXB13		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG1 gene in lung adenocarcinoma condition			[23]
TF Protein Name	Homeobox protein Hox-B13		Transcription Factor Info
Affected Drug/Substrate	Cisplatin
Studied Phenotype	Lung adenocarcinoma [ICD11: 2C25.0]
Tissue	Lung
Related DT Changes	up regulating
Experimental Material	Human lung adenocarcinoma isolates
Detailed Description	Homeobox protein Hox-B13 (HOXB13), influenced by the exogenous cisplatin, has been reported to activate the transcription of ABCG1 gene in lung adenocarcinoma condition , which leads to an increased expression of the drug transporter ATP-binding cassette sub-family G member 1.
PBX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG1 gene in ovarian cancer condition			[24]
TF Protein Name	Pre-B-cell leukemia transcription factor 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Pre-B-cell leukemia transcription factor 1 (PBX1) has been reported to activate the transcription of ABCG1 gene in ovarian cancer condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family G member 1.
PBX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[3]
TF Protein Name	Pre-B-cell leukemia transcription factor 3		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
Class3.2: Paired box factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
PAX5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[1]
TF Protein Name	Paired box protein Pax-5		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Paired box protein Pax-5 (PAX5) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCG1 gene in MCF7 cells			[7]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Transcription factor E2F1 (E2F1) has been reported to bind to the transcription of ABCG1 gene in MCF7 cells, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family G member 1.
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[1]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Bone marrow; Embryo; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
FOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[4]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Embryo; Lung; Pancreatic ductal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 5 TF(s) Regulating This DT
ETS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[3]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
FLI1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCG1 gene in megakaryocytes condition			[18]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of ABCG1 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family G member 1.
Transcriptional Phenomenon2	Direct binding to ABCG1 gene			[4]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
IRF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[5]
TF Protein Name	Interferon regulatory factor 1		Transcription Factor Info
Tissue	Blood; Pancreatic ductal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Interferon regulatory factor 1 (IRF1) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
MYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[1]
TF Protein Name	Transcriptional activator Myb		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional activator Myb (MYB) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
SPI1		Click to Show/Hide to Show 4 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCG1 gene in K562 cells			[25]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of ABCG1 gene in K562 cells, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family G member 1.
Transcriptional Phenomenon2	Binding to ABCG1 gene in acute promyelocytic leukemia condition			[26]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of ABCG1 gene in acute promyelocytic leukemia condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family G member 1.
Transcriptional Phenomenon3	Binding to ABCG1 gene in HL60 condition			[27]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of ABCG1 gene in HL60 condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family G member 1.
Transcriptional Phenomenon4	Direct binding to ABCG1 gene			[4]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
Class3.7: ARID domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
KDM5B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[5]
TF Protein Name	Lysine-specific demethylase 5B		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Lysine-specific demethylase 5B (KDM5B) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
TF Superclass4: Other all-alpha-helical DNA-binding domains
Class4.1: High-mobility group domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SOX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG1 gene in colorectal cancer condition			[28]
TF Protein Name	Transcription factor SOX-2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor SOX-2 (SOX2) has been reported to activate the transcription of ABCG1 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family G member 1.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
EBF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[5]
TF Protein Name	Transcription factor COE1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor COE1 (EBF1) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TP63		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCG1 gene in epithelial to mesenchymal transition condition			[29]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of ABCG1 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family G member 1.
Transcriptional Phenomenon2	Binding to ABCG1 gene in health condition			[30]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of ABCG1 gene in health condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family G member 1.
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
RUNX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCG1 gene in megakaryocytes condition			[18]
TF Protein Name	Runt-related transcription factor 1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of ABCG1 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family G member 1.
RUNX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG1 gene in prostate cancer condition			[31]
TF Protein Name	Runt-related transcription factor 2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of ABCG1 gene in prostate cancer condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family G member 1.
Class6.7: Grainyhead domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
GRHL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[1]
TF Protein Name	Grainyhead-like protein 2 homolog		Transcription Factor Info
Tissue	Breast; Bronchus; Ovary
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
GRHL3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG1 gene			[3]
TF Protein Name	Grainyhead-like protein 3 homolog		Transcription Factor Info
Tissue	Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 3 homolog (GRHL3) can directly bind to the ABCG1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family G member 1.
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold
Class7.1: SMAD/NF-1 DNA-binding domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SMAD4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG1 gene in human embryonic stem cells (hESCs) condition			[32]
TF Protein Name	Mothers against decapentaplegic homolog 4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of ABCG1 gene in human embryonic stem cells (hESCs) condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family G member 1.

References
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19	The transcriptional regulator BCL6 participates in the secondary gene regulatory response to vitamin D. Biochim Biophys Acta. 2015;1849(3):300-8.
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21	Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
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26	Structurally differentiated cis-elements that interact with PU.1 are functionally distinguishable in acute promyelocytic leukemia. J Hematol Oncol. 2013;6:25.
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