Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0071 Transporter Info
Gene Name	ABCG1
Transporter Name	ATP-binding cassette sub-family G member 1
Gene ID	9619
UniProt ID	P45844

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	T0901317 co-treated with Alitretinoin results in increased expression of ABCG1 mRNA			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Estradiol co-treated with Progesterone results in decreased expression of ABCG1 mRNA			[70]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Progesterone results in increased expression of ABCG1 mRNA			[80]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	PPARG mutant form inhibits the reaction Telmisartan results in increased expression of ABCG1 mRNA			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Valproic Acid affects the expression of ABCG1 mRNA			[90]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Valproic Acid affects the methylation of ABCG1 gene			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Estradiol co-treated with Progesterone results in decreased expression of ABCG1 mRNA			[70]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Estradiol co-treated with TGFB1 protein results in increased expression of ABCG1 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cisplatin affects the expression of ABCG1 mRNA			[10]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	IGF1 protein inhibits the reaction Ethanol results in decreased expression of ABCG1 mRNA			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	IGF1 protein inhibits the reaction Ethanol results in decreased expression of ABCG1 protein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of ABCG1 intron			[52]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Benzo(a)pyrene affects the methylation of ABCG1 promoter			[56]
Regulation Mechanism				Transcription Factor Info
1,2-linoleoylphosphatidylcholine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	1,2-linoleoylphosphatidylcholine results in decreased expression of ABCG1 protein			[47]
Regulation Mechanism				Transcription Factor Info
2,2',4,4'-tetrabromodiphenyl ether	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ABCG1 mRNA			[48]
Regulation Mechanism				Transcription Factor Info
22-hydroxycholesterol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	22-hydroxycholesterol results in increased expression of ABCG1 mRNA			[4]
Regulation Mechanism				Transcription Factor Info
2,3-bis(3'-hydroxybenzyl)butyrolactone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of ABCG1 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
24-hydroxycholesterol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	24-hydroxycholesterol results in increased expression of ABCG1 protein			[32]
Regulation Mechanism				Transcription Factor Info
8-Bromo Cyclic Adenosine Monophosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of ABCG1 mRNA			[50]
Regulation Mechanism				Transcription Factor Info
afimoxifene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	afimoxifene inhibits the reaction Estrogens results in decreased expression of ABCG1 mRNA			[51]
Regulation Mechanism				Transcription Factor Info
Amphotericin B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amphotericin B analog results in decreased expression of ABCG1 mRNA			[54]
Regulation Mechanism				Transcription Factor Info
Arachidonic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arachidonic Acid results in decreased expression of ABCG1 mRNA			[4]
Regulation Mechanism				Transcription Factor Info
beauvericin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	beauvericin co-treated with enniatins results in decreased expression of ABCG1 mRNA			[55]
Regulation Mechanism				Transcription Factor Info
benzo(e)pyrene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	benzo(e)pyrene results in increased methylation of ABCG1 intron			[52]
Regulation Mechanism				Transcription Factor Info
bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A results in decreased methylation of ABCG1 gene			[57]
Regulation Mechanism				Transcription Factor Info
bis(tri-n-butyltin)oxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bis(tri-n-butyltin)oxide results in increased expression of ABCG1 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
Cadmium Chloride	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of ABCG1 mRNA			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cadmium Chloride results in increased expression of ABCG1 mRNA			[60]
Regulation Mechanism				Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to ABCG1 gene			[61]
Regulation Mechanism				Transcription Factor Info
Chenodeoxycholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCG1 mRNA			[62]
Regulation Mechanism				Transcription Factor Info
chloroacetaldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	chloroacetaldehyde results in decreased expression of ABCG1 mRNA			[12]
Regulation Mechanism				Transcription Factor Info
Cholesterol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Resveratrol results in increased expression of ABCG1 protein which results in increased secretion of Cholesterol			[63]
Regulation Mechanism				Transcription Factor Info
clothianidin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	clothianidin results in decreased expression of ABCG1 mRNA			[38]
Regulation Mechanism				Transcription Factor Info
Copper	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Disulfiram binds to Copper which results in increased expression of ABCG1 mRNA			[64]
Regulation Mechanism				Transcription Factor Info
cordycepin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cordycepin results in increased expression of ABCG1 mRNA			[65]
Regulation Mechanism				Transcription Factor Info
Coumestrol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of ABCG1 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Coumestrol co-treated with Resveratrol results in decreased expression of ABCG1 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
cypermethrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cypermethrin results in decreased expression of ABCG1 mRNA			[34]
Regulation Mechanism				Transcription Factor Info
Deoxycholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCG1 mRNA			[62]
Regulation Mechanism				Transcription Factor Info
Dichlorodiphenyl Dichloroethylene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dichlorodiphenyl Dichloroethylene results in decreased expression of ABCG1 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
di-n-butylphosphoric acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	di-n-butylphosphoric acid affects the expression of ABCG1 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
Disulfiram	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Disulfiram binds to Copper which results in increased expression of ABCG1 mRNA			[64]
Regulation Mechanism				Transcription Factor Info
Diuron	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diuron results in decreased expression of ABCG1 mRNA			[68]
Regulation Mechanism				Transcription Factor Info
Docetaxel	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCG1 gene SNP affects the susceptibility to Docetaxel			[69]
Regulation Mechanism				Transcription Factor Info
Eicosapentaenoic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Eicosapentaenoic Acid results in decreased expression of ABCG1 mRNA			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Eicosapentaenoic Acid results in decreased expression of ABCG1 protein			[4]
Regulation Mechanism				Transcription Factor Info
enniatins	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	beauvericin co-treated with enniatins results in decreased expression of ABCG1 mRNA			[55]
Regulation Mechanism				Transcription Factor Info
entinostat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	entinostat results in increased expression of ABCG1 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
epigallocatechin gallate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	epigallocatechin gallate results in decreased expression of ABCG1 mRNA			[3]
Regulation Mechanism				Transcription Factor Info
Estrogens	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	afimoxifene inhibits the reaction Estrogens results in decreased expression of ABCG1 mRNA			[51]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Estrogens results in decreased expression of ABCG1 mRNA			[51]
Regulation Mechanism				Transcription Factor Info
fatostatin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CGA protein inhibits the reaction fatostatin promotes the reaction T0901317 results in increased expression of ABCG1 mRNA			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	fatostatin promotes the reaction T0901317 results in increased expression of ABCG1 mRNA			[72]
Regulation Mechanism				Transcription Factor Info
Glycochenodeoxycholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCG1 mRNA			[62]
Regulation Mechanism				Transcription Factor Info
Glycocholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCG1 mRNA			[62]
Regulation Mechanism				Transcription Factor Info
Glycodeoxycholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCG1 mRNA			[62]
Regulation Mechanism				Transcription Factor Info
GW 3965	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GW 3965 inhibits the reaction Nicotine results in decreased expression of ABCG1 mRNA			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	GW 3965 inhibits the reaction Nicotine results in decreased expression of ABCG1 protein			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	GW 3965 results in increased expression of ABCG1 mRNA			[73]
Regulation Mechanism				Transcription Factor Info
Hexachlorocyclohexane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hexachlorocyclohexane results in increased expression of ABCG1 mRNA			[11]
Regulation Mechanism				Transcription Factor Info
lly-283	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	lly-283 results in increased expression of ABCG1 mRNA			[74]
Regulation Mechanism				Transcription Factor Info
Methapyrilene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methapyrilene results in increased methylation of ABCG1 intron			[52]
Regulation Mechanism				Transcription Factor Info
nickel chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	nickel chloride results in increased expression of ABCG1 mRNA			[31]
Regulation Mechanism				Transcription Factor Info
Nicotine	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GW 3965 inhibits the reaction Nicotine results in decreased expression of ABCG1 mRNA			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	GW 3965 inhibits the reaction Nicotine results in decreased expression of ABCG1 protein			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Nicotine results in decreased expression of ABCG1 mRNA			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Nicotine results in decreased expression of ABCG1 protein			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Vecuronium Bromide inhibits the reaction Nicotine results in decreased expression of ABCG1 mRNA			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Vecuronium Bromide inhibits the reaction Nicotine results in decreased expression of ABCG1 protein			[18]
Regulation Mechanism				Transcription Factor Info
obeticholic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	obeticholic acid results in decreased expression of ABCG1 mRNA			[14]
Regulation Mechanism				Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in increased expression of ABCG1 mRNA			[76]
Regulation Mechanism				Transcription Factor Info
Oxygen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxygen deficiency results in decreased expression of ABCG1 mRNA			[12]
Regulation Mechanism				Transcription Factor Info
Ozone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ozone inhibits the reaction T0901317 results in increased expression of ABCG1 mRNA			[77]
Regulation Mechanism				Transcription Factor Info
perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctane sulfonic acid results in increased expression of ABCG1 mRNA			[22]
Regulation Mechanism				Transcription Factor Info
perfluorooctanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid results in increased expression of ABCG1 mRNA			[78]
Regulation Mechanism				Transcription Factor Info
pirinixic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pirinixic acid binds to and results in increased activity of PPARA protein which results in decreased expression of ABCG1 mRNA			[79]
Regulation Mechanism				Transcription Factor Info
potassium perchlorate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	potassium perchlorate results in decreased expression of ABCG1 mRNA			[16]
Regulation Mechanism				Transcription Factor Info
quinocetone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	quinocetone results in increased expression of ABCG1 mRNA			[81]
Regulation Mechanism				Transcription Factor Info
Silicon Dioxide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog results in decreased expression of ABCG1 mRNA			[85]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Silicon Dioxide results in decreased expression of ABCG1 mRNA			[86]
Regulation Mechanism				Transcription Factor Info
stearic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	stearic acid results in increased expression of ABCG1 mRNA			[4]
Regulation Mechanism				Transcription Factor Info
Succimer	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Succimer co-treated with Magnetite Nanoparticles results in decreased expression of ABCG1 mRNA			[87]
Regulation Mechanism				Transcription Factor Info
T0901317	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CGA protein inhibits the reaction fatostatin promotes the reaction T0901317 results in increased expression of ABCG1 mRNA			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	CGA protein inhibits the reaction T0901317 results in increased expression of ABCG1 mRNA			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	fatostatin promotes the reaction T0901317 results in increased expression of ABCG1 mRNA			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Ozone inhibits the reaction T0901317 results in increased expression of ABCG1 mRNA			[77]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	T0901317 co-treated with Alitretinoin results in increased expression of ABCG1 mRNA			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	T0901317 results in increased expression of ABCG1 mRNA			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	T0901317 results in increased expression of ABCG1 protein			[20]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	triphenyl phosphate inhibits the reaction T0901317 results in increased expression of ABCG1 mRNA			[88]
Regulation Mechanism				Transcription Factor Info
triadimefon	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	triadimefon results in increased expression of ABCG1 mRNA			[36]
Regulation Mechanism				Transcription Factor Info
tributyltin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tributyltin results in increased expression of ABCG1 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	trichostatin A results in decreased expression of ABCG1 mRNA			[36]
Regulation Mechanism				Transcription Factor Info
triphenyl phosphate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	triphenyl phosphate affects the expression of ABCG1 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	triphenyl phosphate inhibits the reaction T0901317 results in increased expression of ABCG1 mRNA			[88]
Regulation Mechanism				Transcription Factor Info
urushiol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	urushiol results in increased expression of ABCG1 mRNA			[89]
Regulation Mechanism				Transcription Factor Info
Vecuronium Bromide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vecuronium Bromide inhibits the reaction Nicotine results in decreased expression of ABCG1 mRNA			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Vecuronium Bromide inhibits the reaction Nicotine results in decreased expression of ABCG1 protein			[18]
Regulation Mechanism				Transcription Factor Info
Vincristine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vincristine results in decreased susceptibility to Vincristine which results in decreased expression of ABCG1 mRNA			[91]
Regulation Mechanism				Transcription Factor Info
ZM 241385	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ZM 241385 inhibits the reaction Resveratrol results in increased expression of ABCG1 protein			[82]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Rosiglitazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rosiglitazone increases the expression of ABCG1			[1]
Regulation Mechanism	via enhancement of Peroxisome proliferator-activated receptor gamma (PPARG)			Transcription Factor Info
Cell System	C57BL/6J alveolar macrophages
Raloxifene Hydrochloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Raloxifene Hydrochloride affects the expression of ABCG1			[2]
Acetylcysteine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetylcysteine inhibits the expression of ABCG1			[3]
Alitretinoin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Alitretinoin increases the expression of ABCG1			[4]
Clozapine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clozapine increases the expression of ABCG1			[5]
Rosuvastatin Calcium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rosuvastatin Calcium inhibits the expression of ABCG1			[6]
Simvastatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Simvastatin inhibits the expression of ABCG1			[7]
Progesterone	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Progesterone inhibits the expression of ABCG1			[8]
Telmisartan	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Telmisartan increases the expression of ABCG1			[9]
Decitabine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Decitabine affects the expression of ABCG1			[10]
Lindane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lindane increases the expression of ABCG1			[11]
Cidofovir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cidofovir inhibits the expression of ABCG1			[12]
Ibuprofen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ibuprofen increases the expression of ABCG1			[12]
Ifosfamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ifosfamide inhibits the expression of ABCG1			[12]
Tamoxifen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tamoxifen increases the expression of ABCG1			[13]
Obeticholic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Obeticholic acid inhibits the expression of ABCG1			[14]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen increases the expression of ABCG1			[15]
Potassium perchlorate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Potassium perchlorate inhibits the expression of ABCG1			[16]
Dronabinol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dronabinol inhibits the expression of ABCG1			[17]
Nicotine polacrilex	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nicotine polacrilex inhibits the expression of ABCG1			[18]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sunitinib increases the expression of ABCG1			[19]
Rifampin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifampin increases the expression of ABCG1			[20]
Valproic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of ABCG1			[21]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine increases the expression of ABCG1			[22]
Estradiol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol increases the expression of ABCG1			[23]
Regulation Mechanism	via enhancement of Oxysterols receptor LXR-alpha (NR1H3)			Transcription Factor Info
Affected Drug/Substrate	Cholesterol	Modulation Type	Inducer
Cell System	C57BL/6 mice vascular smooth muscle cells
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tretinoin increases the expression of ABCG1			[24]
Regulation Mechanism	via enhancement of Oxysterols receptor LXR-alpha (NR1H3)			Transcription Factor Info
Affected Drug/Substrate	Cholesterol	Modulation Type	Inducer
Cell System	Mouse macrophage cells (J774A1)
Cisplatin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cisplatin increases the expression of ABCG1			[25]
Regulation Mechanism	via enhancement of Homeobox protein Hox-B13 (HOXB13)			Transcription Factor Info
Affected Drug/Substrate	Cisplatin	Modulation Type	Inducer
Cell System	Human lung adenocarcinoma isolates
Drug Marketed but not Approved by US FDA
Linoleic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Linoleic Acid inhibits the expression of ABCG1			[4]
Clodronic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clodronic Acid inhibits the expression of ABCG1			[12]
Drug in Phase 3 Trial
Curcumin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Curcumin increases the expression of ABCG1			[27]
Regulation Mechanism	via enhancement of Oxysterols receptor LXR-alpha (NR1H3)			Transcription Factor Info
Cell System	Mouse atherosclerotic lesions
Triclosan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Triclosan increases the expression of ABCG1			[41]
Epigallocatechin gallate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Epigallocatechin gallate inhibits the expression of ABCG1			[46]
Drug in Phase 2 Trial
MS-275	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	MS-275 increases the expression of ABCG1			[35]
Ethanol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethanol inhibits the expression of ABCG1			[42]
Drug in Phase 1 Trial
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trichostatin A increases the expression of ABCG1			[29]
Regulation Mechanism	via enhancement of Oxysterols receptor LXR-alpha (NR1H3)			Transcription Factor Info
Cell System	ApoE deficient mice
Palmitic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Palmitic Acid increases the expression of ABCG1			[4]
Drug in Preclinical Test
Oleic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oleic Acid inhibits the expression of ABCG1			[4]
Investigative Drug
Arachidonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arachidonic acid inhibits the expression of ABCG1			[4]
Icosapentum	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Icosapentum inhibits the expression of ABCG1			[4]
27-hydroxycholesterol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	27-hydroxycholesterol increases the expression of ABCG1			[20]
CS-6969	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CS-6969 increases the expression of ABCG1			[32]
Tributyltin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tributyltin increases the expression of ABCG1			[11]
Patented Pharmaceutical Agent
TO-901317	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	TO-901317 increases the expression of ABCG1			[26]
Regulation Mechanism	via enhancement of Oxysterols receptor LXR-alpha (NR1H3)			Transcription Factor Info
Cell System	Chinese hamster ovary epithelial cells (CHO)
GW-3965	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GW-3965 increases the expression of ABCG1			[28]
Regulation Mechanism	via enhancement of Oxysterols receptor LXR-alpha (NR1H3)			Transcription Factor Info
Cell System	Human alveolar macrophages
GSK-J4	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GSK-J4 increases the expression of ABCG1			[39]
Natural Product
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution increases the expression of ABCG1			[45]
Resveratrol	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Coumestrol co-treated with Resveratrol results in decreased expression of ABCG1 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	PPARG protein promotes the reaction Resveratrol results in increased expression of ABCG1 mRNA			[82]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Resveratrol results in increased activity of ABCG1 protein			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Resveratrol results in increased expression of ABCG1 mRNA			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Resveratrol results in increased expression of ABCG1 protein			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Resveratrol results in increased expression of ABCG1 protein which results in increased secretion of Cholesterol			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	ZM 241385 inhibits the reaction Resveratrol results in increased expression of ABCG1 protein			[82]
Regulation Mechanism				Transcription Factor Info
Dietary Constituent
Stearic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Stearic acid increases the expression of ABCG1			[4]
Environmental toxicant
Zinc	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zinc increases the expression of ABCG1			[33]
Diazinon	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diazinon increases the expression of ABCG1			[11]
Mycotoxins
Aflatoxin B1	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 inhibits the expression of ABCG1			[37]
DT Modulation2	Aflatoxin B1 results in decreased methylation of ABCG1 intron			[52]
Regulation Mechanism				Transcription Factor Info
aflatoxin B2	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	aflatoxin B2 results in increased methylation of ABCG1 intron			[52]
Regulation Mechanism				Transcription Factor Info
ochratoxin A	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ochratoxin A metabolite results in decreased expression of ABCG1 mRNA			[11]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ochratoxin A results in decreased expression of ABCG1 mRNA			[11]
Regulation Mechanism				Transcription Factor Info
Acute Toxic Substance
Mercury	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mercury increases the expression of ABCG1			[30]
Nickel chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nickel chloride increases the expression of ABCG1			[31]
Ochratoxin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ochratoxin A inhibits the expression of ABCG1			[11]
Carcinogen
Benzo(a)pyrene	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of ABCG1			[43]
Cadmium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of ABCG1 mRNA			[59]
Regulation Mechanism				Transcription Factor Info
Nickel	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nickel results in decreased expression of ABCG1 mRNA			[75]
Regulation Mechanism				Transcription Factor Info
Fungicide
Triadimefon	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Triadimefon increases the expression of ABCG1			[36]
Tebuconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tebuconazole inhibits the expression of ABCG1			[40]
tebuconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tebuconazole results in decreased expression of ABCG1 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
Pesticide/Insecticide
Cypermethrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cypermethrin inhibits the expression of ABCG1			[34]
Clothianidin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clothianidin inhibits the expression of ABCG1			[38]
Health and Environmental Toxicant
Perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Perfluorooctane sulfonic acid increases the expression of ABCG1			[22]
Dibutyl Phthalate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dibutyl Phthalate inhibits the expression of ABCG1			[44]

References
1	PPAR-gamma pathways attenuate pulmonary granuloma formation in a carbon nanotube induced murine model of sarcoidosis. Biochem Biophys Res Commun. 2018 Sep 5;503(2):684-690.
2	Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell. 2004 Mar;15(3):1262-72.
3	Molecular mechanisms of action of angiopreventive anti-oxidants on endothelial cells: microarray gene expression analyses. Mutat Res. 2005 Dec 11;591(1-2):198-211.
4	Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR/RXR responsive element. Atherosclerosis. 2007 Mar;191(1):11-21.
5	Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses. Immunology. 2007 Jun;121(2):266-75.
6	In-vivo effects of simvastatin and rosuvastatin on global gene expression in peripheral blood leucocytes in a human inflammation model. Pharmacogenet Genomics. 2008 Feb;18(2):109-20.
7	Combining simvastatin with the farnesyltransferase inhibitor tipifarnib results in an enhanced cytotoxic effect in a subset of primary CD34+ acute myeloid leukemia samples. Clin Cancer Res. 2009 May 1;15(9):3076-83.
8	Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod. 2011 Jul;26(7):1813-25.
9	Telmisartan ameliorates lipopolysaccharide-induced innate immune response through peroxisome proliferator-activated receptor-Gamma activation in human monocytes. J Hypertens. 2012 Jan;30(1):87-96.
10	Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003.
11	Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
12	Transcriptomics hit the target: Monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
13	Inhibition of Macrophage CD36 Expression and Cellular Oxidized Low Density Lipoprotein (oxLDL) Accumulation by Tamoxifen: A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) Gamma-DEPENDENT MECHANISM. J Biol Chem. 2016 Aug 12;291(33):16977-89.
14	Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
15	Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
16	Changes in trophoblasts gene expression in response to perchlorate exposition. Toxicol In Vitro. 2018 Aug;50:328-335.
17	THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89.
18	Placental mechanism of prenatal nicotine exposure-reduced blood cholesterol levels in female fetal rats. Toxicol Lett. 2018 Oct 15;296:31-38.
19	Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761.
20	PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine. J Lipid Res. 2007 Feb;48(2):373-84.
21	Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
22	Impairment of bile acid metabolism by perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in human HepaRG hepatoma cells. Arch Toxicol. 2020 May;94(5):1673-1686.
23	17beta-estradiol promotes cholesterol efflux from vascular smooth muscle cells through a liver X receptor -dependent pathway. Int J Mol Med. 2014 Mar;33(3):550-8.
24	Retinoic acid induces macrophage cholesterol efflux and inhibits atherosclerotic plaque formation in apoE-deficient mice. Br J Nutr. 2015 Aug 28;114(4):509-18.
25	HOXB13 networking with ABCG1/EZH2/Slug mediates metastasis and confers resistance to cisplatin in lung adenocarcinoma patients. Theranostics. 2019 Apr 6;9(7):2084-2099.
26	Regulation of central nervous system cholesterol homeostasis by the liver X receptor agonist TO-901317. Neurosci Lett. 2007 Aug 9;423(1):47-52.
27	Molecular mechanism of curcumin on the suppression of cholesterol accumulation in macrophage foam cells and atherosclerosis. Mol Nutr Food Res. 2012 May;56(5):691-701.
28	The role of the liver X receptor in chronic obstructive pulmonary disease. Respir Res. 2013 Oct 12;14(1):106.
29	Enhancing PPARgamma by HDAC inhibition reduces foam cell formation and atherosclerosis in ApoE deficient mice. Pharmacol Res. 2020 Oct;160:105059.
30	Microarray analysis of mercury-induced changes in gene expression in human liver carcinoma (HepG2) cells: importance in immune responses. Int J Environ Res Public Health. 2006 Jun;3(2):141-73.
31	The contact allergen nickel triggers a unique inflammatory and proangiogenic gene expression pattern via activation of NF-kappaB and hypoxia-inducible factor-1alpha. J Immunol. 2007 Mar 1;178(5):3198-207.
32	Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells. Mol Neurodegener. 2009 Jan 6;4:1.
33	Genomic analysis, cytokine expression, and microRNA profiling reveal biomarkers of human dietary zinc depletion and homeostasis. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):20970-5.
34	Successful validation of genomic biomarkers for human immunotoxicity in Jurkat T cells in vitro. J Appl Toxicol. 2015 Jul;35(7):831-41.
35	A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
36	Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
37	Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma. Toxicology. 2016 Mar 28;350-352:31-9.
38	The neonicotinoid insecticide Clothianidin adversely affects immune signaling in a human cell line. Sci Rep. 2017 Oct 18;7(1):13446.
39	Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells. J Biol Chem. 2018 Feb 16;293(7):2422-2437.
40	The azole fungicide tebuconazole affects human CYP1A1 and CYP1A2 expression by an aryl hydrocarbon receptor-dependent pathway. Food Chem Toxicol. 2019 Jan;123:481-491.
41	Transcriptome and DNA Methylome Dynamics during Triclosan-Induced Cardiomyocyte Differentiation Toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
42	Prenatal ethanol exposure-induced a low level of foetal blood cholesterol and its mechanism of IGF1-related placental cholesterol transport dysfunction. Toxicology. 2019 Aug 1;424:152237.
43	Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297.
44	Di-n-butyl phthalate promotes lipid accumulation via the miR200c-5p-ABCA1 pathway in THP-1 macrophages. Environ Pollut. 2020 Sep;264:114723.
45	Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model. Arch Toxicol. 2021 May;95(5):1739-1761.
46	Integrated transcriptomic and metabolomic analyses to characterize the anti-cancer effects of (-)-epigallocatechin-3-gallate in human colon cancer cells. Toxicol Appl Pharmacol. 2020 Aug 15;401:115100.
47	An induction in hepatic HDL secretion associated with reduced ATPase expression. Am J Pathol. 2009;175(4):1777-87.
48	2,2',4,4'-Tetrabromodiphenyl Ether (PBDE 47) Selectively Stimulates Proatherogenic PPAR Gamma Signatures in Human THP-1 Macrophages to Contribute to Foam Cell Formation. Chem Res Toxicol. 2022 Jun 20;35(6):1023-1035.
49	Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
50	Mechanistic profiling of the cAMP-dependent steroidogenic pathway in the H295R endocrine disrupter screening system: new endpoints for toxicity testing. Toxicol Lett. 2012;208(2):174-84.
51	High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy. Proc Natl Acad Sci U S A. 2011;108(5):2058-63.
52	Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018;121:214-223.
53	The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver. J Lipid Res. 2005;46(10):2151-67.
54	Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017;27(7):537-543.
55	Transcriptional study after Beauvericin and Enniatin B combined exposure in Jurkat T cells. Food Chem Toxicol. 2019 Aug;130:122-129.
56	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
57	DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019;11(1):138.
58	Toxicogenomics-based identification of mechanisms for direct immunotoxicity. Toxicol Sci. 2013 Oct;135(2):328-46.
59	Cadmium acute exposure induces metabolic and transcriptomic perturbations in human mature adipocytes. Toxicology. 2022;470:153153.
60	Evaluation of Cd-induced cytotoxicity in primary human keratinocytes. Hum Exp Toxicol. 2024;43:9603271231224458.
61	Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines. Exp Cell Res. 2017;353(1):6-15.
62	Dataset on transcriptomic profiling of cholestatic liver injury induced by food additives and a cosmetic ingredient. Data Brief. 2021;38:107373.
63	Resveratrol prevents the impairment of advanced glycosylation end products (AGE) on macrophage lipid homeostasis by suppressing the receptor for AGE via peroxisome proliferator-activated receptor gamma activation. Int J Mol Med. 2010;25(5):729-34.
64	Disulfiram suppresses growth of the malignant pleural mesothelioma cells in part by inducing apoptosis. PLoS One. 2014;9(4):e93711.
65	Cordycepin activates AMP-activated protein kinase (AMPK) via interaction with the 1 subunit. J Cell Mol Med. 2014;18(2):293-304.
66	High-Throughput Transcriptomics of Nontumorigenic Breast Cells Exposed to Environmentally Relevant Chemicals. Environ Health Perspect. 2024;132(4):47002.
67	Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60-69 Years of Age: Evidence from the China BAPE Study. Environ Health Perspect. 2023;131(4):47009.
68	The DCMU Herbicide Shapes T-cell Functions By Modulating Micro-RNA Expression Profiles. Front Immunol. 2022;13:925241.
69	Pharmacogenomics variation in drug metabolizing enzymes and transporters in relation to docetaxel toxicity in Lebanese breast cancer patients: paving the way for OMICs in low and middle income countries. OMICS. 2013;17(7):353-67.
70	Ovarian steroids, mitogen-activated protein kinases, and/or aspartic proteinases cooperate to control endometrial remodeling by regulating gene expression in the stroma and glands. Endocrinology. 2010;151(9):4515-26.
71	Transforming growth factor beta1 targets estrogen receptor signaling in bronchial epithelial cells. Respir Res. 2018 Aug 30;19(1):160.
72	The liver X receptors and sterol regulatory element binding proteins alter progesterone secretion and are regulated by human chorionic gonadotropin in human luteinized granulosa cells. Mol Cell Endocrinol. 2018;473:124-135.
73	Inhibition of progesterone production in human luteinized granulosa cells treated with LXR agonists. Mol Hum Reprod. 2007 Jun;13(6):373-9.
74	PRMT5 inhibition shows in vitro efficacy against H3K27M-altered diffuse midline glioma, but does not extend survival in vivo. Sci Rep. 2024;14(1):328.
75	Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response. J Allergy Clin Immunol. 2014;134(2):362-72.
76	A multi-omics approach to elucidate okadaic acid-induced changes in human HepaRG hepatocarcinoma cells. Arch Toxicol. 2024;98(9):2919-2935.
77	Ozone-derived Oxysterols Affect Liver X Receptor (LXR) Signaling: A POTENTIAL ROLE FOR LIPID-PROTEIN ADDUCTS. J Biol Chem. 2016;291(48):25192-25206.
78	Perfluorooctanoic acid (PFOA) affects distinct molecular signalling pathways in human primary hepatocytes. Toxicology. 2015;333:53-62.
79	Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human. PLoS One. 2009;4(8):e6796.
80	Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. BMC Cancer. 2007 Dec 11;7:223.
81	Genomic and proteomic analysis of the inhibition of synthesis and secretion of aldosterone hormone induced by quinocetone in NCI-H295R cells. Toxicology. 2016;350-352:1-14.
82	Resveratrol mediates anti-atherogenic effects on cholesterol flux in human macrophages and endothelium via PPAR Gamma and adenosine. Eur J Pharmacol. 2013 Jan 5;698(1-3):299-309.
83	Resveratrol modulates ATPase activity of liposome-reconstituted ABCG1. FEBS Lett. 2013;587(15):2359-63.
84	Resveratrol regulates the expression of LXR-alpha in human macrophages. Biochem Biophys Res Commun. 2006 Sep 29;348(3):1047-54.
85	High-throughput, quantitative assessment of the effects of low-dose silica nanoparticles on lung cells: grasping complex toxicity with a great depth of field. BMC Genomics. 2015;16(1):315.
86	Indications for distinct pathogenic mechanisms of asbestos and silica through gene expression profiling of the response of lung epithelial cells. Hum Mol Genet. 2015;24(5):1374-89.
87	DMSA-Coated Iron Oxide Nanoparticles Greatly Affect the Expression of Genes Coding Cysteine-Rich Proteins by Their DMSA Coating. Chem Res Toxicol. 2015;28(10):1961-74.
88	Screening of House Dust from Chinese Homes for Chemicals with Liver X Receptors Binding Activities and Characterization of Atherosclerotic Activity Using an in Vitro Macrophage Cell Line and [Formula: see text] Mice. Environ Health Perspect. 2019 Nov;127(11):117003.
89	CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020;386:114828.
90	Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20.
91	L-type calcium channel blockers reverse docetaxel and vincristine-induced multidrug resistance independent of ABCB1 expression in human lung cancer cell lines. Toxicol Lett. 2010 Feb 15;192(3):408-18.

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