Detail Information of DT Wildtype Structure
| General Information of Drug Transporter (DT) | ||||||
|---|---|---|---|---|---|---|
| DT ID | DTD0071 Transporter Info | |||||
| Gene Name | ABCG1 | |||||
| Transporter Name | ATP-binding cassette sub-family G member 1 | |||||
| Gene ID | ||||||
| UniProt ID | ||||||
| Modelled Structures of This DT | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Detail Information of Structural Model | ||||||
| Method | Homology modeling | |||||
| Template PDB | 6ETI_A | Identity | 30.957% | |||
| Performance | Minimized Score | -1183.878 kcal/mol | ||||
| Ramachandra Favored | Medium |
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| QMEANBrane Quality | Medium |
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| Ramachandran Plot |
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| Click to Save Ramachandran Plot in PNG Format | ||||||
| Ramz Z Score | -0.93 ±0.34 | |||||
| Residues in Favored Region | 504 | Ramachandran favored | 97.86% | |||
| Number of Outliers | 1 | Ramachandran outliers | 0.19% | |||
| Local Quality |
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| Click to Save Local Quality Plot in PNG Format | ||||||
| QMEANBrane Score | 0.78 | |||||
| AlphaFold Protein Structure Database | ||||||
| SWISS-MODEL Database | ||||||
| Experimental Structures of This DT | ||||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref | |
| 7FDV | EM | 3.26 Å | Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/D | |||||
| Sequence Length | 678 | Mutation | No | |||
| 7OZ1 | EM | 4 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/B | |||||
| Sequence Length | 680 | Mutation | Yes | |||
| 7R8C | EM | 3.7 Å | Homo sapiens | [3] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/B | |||||
| Sequence Length | 666 | Mutation | No | |||
| 7R8D | EM | 3.2 Å | Homo sapiens | [3] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/B | |||||
| Sequence Length | 666 | Mutation | No | |||
| 7R8E | EM | 3.7 Å | Homo sapiens | [3] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/B | |||||
| Sequence Length | 666 | Mutation | No | |||
| References | ||||||
| 1 | Structure and transport mechanism of the human cholesterol transporter ABCG1. Cell Rep. 2022;38(4):110298. | |||||
| 2 | Structure of the Human Cholesterol Transporter ABCG1. J Mol Biol. 2021;433(21):167218. | |||||
| 3 | Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc Natl Acad Sci U S A. 2021;118(34). | |||||
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