Drug Transporter (DT) Information

General Information of DT
DT ID DTD0028
Gene Name SLC47A2
Protein Name Multidrug and toxin extrusion protein 2
Gene ID
146802
UniProt ID
Q86VL8
TCDB ID
2.A.66.1.20
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms Kidney-specific H(+)/organic cation antiporter; MATE-2; MATE2; MATE2-B; MATE2-K; MATE2K; SLC47A2; Solute carrier family 47 member 2; hMATE-2
DT Family Multidrug/Oligosaccharidyl-Lipid/Polysaccharide (MOP) Flippase Superfamily
Multi Antimicrobial Extrusion (MATE) Family
Tissue Specificity Isoform 3 is predominantly expressed inkidney. Isoform 6 is expressed in brain.
Function This transporter is reesponsible for the secretion of cationic drugs across the brush border membranes, such as tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir.
Disease(s) Cytomegalovirus infections [ICD-11:1D82]
Ovarian cancer [ICD-11:2C73]
Type 2 diabetes [ICD-11:5A11]
Ventricular arrhythmias [ICD-11:BC71]
Herpes simplex virus infection [ICD-11:1F00]
Maintenance of normal sinus rhythm [ICD-11:BC81.3]
Endogenous Substrate(s) H+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Multidrug and toxin extrusion protein 2
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Multidrug and toxin extrusion protein 2
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Multidrug and toxin extrusion protein 2
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Multidrug and toxin extrusion protein 2
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Multidrug and toxin extrusion protein 2
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Multidrug and toxin extrusion protein 2
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Multidrug and toxin extrusion protein 2
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Multidrug and toxin extrusion protein 2
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Multidrug and toxin extrusion protein 2
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           9 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Abemaciclib
 Approved Drug Info Breast cancer 2C60-2C6Z [1]
Acyclovir
 Approved Drug Info Shingles 1.00E+91 [2]
Cimetidine
 Approved Drug Info Acid reflux disorder DA22 [2]
Dofetilide
 Approved Drug Info Maintenance of normal sinus rhythm BC81.3 [3]
Estrone sulfate
 Approved Drug Info Menopausal symptoms MF32 [2]
Ganciclovir
 Approved Drug Info Cytomegalovirus infections 1D82 [2]
Metformin
 Approved Drug Info Type 2 diabetes 5A11 [2]
Procainamide
 Approved Drug Info Ventricular arrhythmias BC71 [2]
Topotecan
 Approved Drug Info Ovarian cancer 2C73 [2]

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Tetraethylammonium
 Phase 2 Drug Info Hyperlipidaemia 5C8Z [2]

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
N-methylpyridinium
 Preclinical Drug Info Colon cancer 2B90.Z [2]

Endogenous Metabolites (EMs) Handled by This DT

 Endogenous Metabolites (EMs)

 Click to Show/Hide the Full List of EMs:           4 EMs in Total
EM Name PubChem CID Detail Experimental Material Ref
Creatinine
588
EM Info Identified using HEK293 cells-MATE2 [4]
Guanidine
3520
EM Info Identified using HEK293 cells-MATE2 [4]
Testosterone
6013
EM Info Unclear experiment used for identifying this EM [5]
Thiamine
1130
EM Info Identified using HEK293 cells-MATE2 [4]

Drug-DT Affinity Assessed by Cell Line

 Approved Drug

 Click to Show/Hide the Full List of Drug:         84 Drugs in Total
Drug Name Highest Status Detail Cell Line Affinity Ref
Acyclovir Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =4320 microM [2]
Acyclovir Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =4320 microM [2]
Acyclovir Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =4320 microM [2]
Acyclovir Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =4320 microM [2]
Acyclovir Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =4320 microM [2]
Acyclovir Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =4320 microM [2]
Acyclovir Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =4320 microM [2]
Acyclovir Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =4320 microM [2]
Acyclovir Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =4320 microM [2]
Cimetidine Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =120 microM [2]
Cimetidine Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =370 microM [4]
Cimetidine Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =120 microM [2]
Cimetidine Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =370 microM [4]
Cimetidine Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =120 microM [2]
Cimetidine Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =370 microM [4]
Cimetidine Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =120 microM [2]
Cimetidine Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =370 microM [4]
Cimetidine Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =120 microM [2]
Cimetidine Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =370 microM [4]
Cimetidine Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =120 microM [2]
Cimetidine Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =370 microM [4]
Cimetidine Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =120 microM [2]
Cimetidine Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =370 microM [4]
Estrone sulfate Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =850 microM [2]
Estrone sulfate Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =850 microM [2]
Estrone sulfate Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =850 microM [2]
Estrone sulfate Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =850 microM [2]
Estrone sulfate Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =850 microM [2]
Estrone sulfate Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =850 microM [2]
Estrone sulfate Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =850 microM [2]
Estrone sulfate Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =850 microM [2]
Estrone sulfate Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =850 microM [2]
Estrone sulfate Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =850 microM [2]
Estrone sulfate Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =850 microM [2]
Estrone sulfate Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =850 microM [2]
Estrone sulfate Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =850 microM [2]
Estrone sulfate Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =850 microM [2]
Estrone sulfate Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =850 microM [2]
Estrone sulfate Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =850 microM [2]
Estrone sulfate Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =850 microM [2]
Estrone sulfate Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =850 microM [2]
Estrone sulfate Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =850 microM [2]
Estrone sulfate Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =850 microM [2]
Estrone sulfate Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =850 microM [2]
Estrone sulfate Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =850 microM [2]
Ganciclovir Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =4280 microM [2]
Ganciclovir Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =4280 microM [2]
Ganciclovir Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =4280 microM [2]
Ganciclovir Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =4280 microM [2]
Ganciclovir Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =4280 microM [2]
Ganciclovir Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =4280 microM [2]
Ganciclovir Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =4280 microM [2]
Ganciclovir Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =4280 microM [2]
Ganciclovir Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =4280 microM [2]
Metformin Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =1050 microM [4]
Metformin Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =1980 microM [2]
Metformin Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =1050 microM [4]
Metformin Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =1980 microM [2]
Metformin Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =1050 microM [4]
Metformin Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =1980 microM [2]
Metformin Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =1050 microM [4]
Metformin Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =1980 microM [2]
Metformin Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =1050 microM [4]
Metformin Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =1980 microM [2]
Metformin Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =1050 microM [4]
Metformin Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =1980 microM [2]
Metformin Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =1050 microM [4]
Metformin Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =1980 microM [2]
Metformin Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =1050 microM [4]
Metformin Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =1980 microM [2]
Metformin Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =1050 microM [4]
Metformin Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =1980 microM [2]
Procainamide Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =1580 microM [2]
Procainamide Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =4100 microM [4]
Procainamide Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =1580 microM [2]
Procainamide Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =4100 microM [4]
Procainamide Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =1580 microM [2]
Procainamide Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =4100 microM [4]
Topotecan Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =60 microM [2]
Topotecan Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =60 microM [2]
Topotecan Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =60 microM [2]
Topotecan Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =60 microM [2]
Topotecan Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =60 microM [2]
Topotecan Approved Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =60 microM [2]

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:         10 Drugs in Total
Drug Name Highest Status Detail Cell Line Affinity Ref
Tetraethylammonium Phase 2 Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =760 microM [2]
Tetraethylammonium Phase 2 Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =830 microM [4]
Tetraethylammonium Phase 2 Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =760 microM [2]
Tetraethylammonium Phase 2 Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =830 microM [4]
Tetraethylammonium Phase 2 Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =760 microM [2]
Tetraethylammonium Phase 2 Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =830 microM [4]
Tetraethylammonium Phase 2 Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =760 microM [2]
Tetraethylammonium Phase 2 Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =830 microM [4]
Tetraethylammonium Phase 2 Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =760 microM [2]
Tetraethylammonium Phase 2 Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =830 microM [4]

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:         10 Drugs in Total
Drug Name Highest Status Detail Cell Line Affinity Ref
N-methylpyridinium Preclinical Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =93.5 microM [4]
N-methylpyridinium Preclinical Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =110 microM [2]
N-methylpyridinium Preclinical Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =93.5 microM [4]
N-methylpyridinium Preclinical Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =110 microM [2]
N-methylpyridinium Preclinical Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =93.5 microM [4]
N-methylpyridinium Preclinical Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =110 microM [2]
N-methylpyridinium Preclinical Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =93.5 microM [4]
N-methylpyridinium Preclinical Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =110 microM [2]
N-methylpyridinium Preclinical Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =93.5 microM [4]
N-methylpyridinium Preclinical Drug Info Human embryonic kidney cells (HEK293)-MATE2K Km =110 microM [2]
References
1 Abemaciclib Inhibits Renal Tubular Secretion Without Changing Glomerular Filtration Rate. Clin Pharmacol Ther. 2019 May;105(5):1187-1195.
2 Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71.
3 FDA Drug Development and Drug Interactions
4 Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2. J Am Soc Nephrol. 2006 Aug;17(8):2127-35.
5 Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. Pharm Res. 2007 Jul;24(7):1227-51.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.