| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0534 | ||||
| Gene Name | CACNA1C | ||||
| Protein Name | Voltage-gated calcium channel alpha Cav1.2 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:5GJV_A Identity:69.088% Minimized Score:-2785.464 kcal/mol Detail: Structure Info |
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| Synonyms | CACH2; CACN2; CACNA1C; CACNL1A1; CCHL1A1; CaV1.2; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; LQT8; TS; Voltage-dependent L-type calcium channel subunit alpha-1C; Voltage-gated calcium channel subunit alpha Cav1.2 | ||||
| DT Family | Voltage-Gated Ion Channel (VIC) Superfamily ; | ||||
| Tissue Specificity | Detected throughout the brain, includinghippocampus, cerebellum and amygdala, throughout the heart andvascular system, including ductus arteriosus, in urinary bladder,and in retina and sclera in the eye (PubMed:15454078). Expressedin brain, heart, jejunum, ovary, pancreatic beta-cells andvascular smooth muscle. Overall expression is reduced inatherosclerotic vascular smooth muscle. | ||||
| Function | This transporter mediates influx of calcium ions into the cytoplasm and plays an important role in excitation-contraction coupling in the heart. Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. | ||||
| Endogenous Substrate(s) | Ca2+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Voltage-gated calcium channel alpha Cav1.2 |
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(β) Cell Distribution Level of Voltage-gated calcium channel alpha Cav1.2 |
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(γ) Organelle Distribution Level of Voltage-gated calcium channel alpha Cav1.2 |
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Regulatory Variability Data of This DT |
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(α) Microbiota Influence of Voltage-gated calcium channel alpha Cav1.2 |
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(β) Post-translational Modification of Voltage-gated calcium channel alpha Cav1.2 |
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(γ) Transcriptional Regulation of Voltage-gated calcium channel alpha Cav1.2 |
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(δ) Epigenetic Regulation of Voltage-gated calcium channel alpha Cav1.2 |
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(ε) Exogenous Modulation of Voltage-gated calcium channel alpha Cav1.2 |
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Structural Variability Data of This DT |
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(α) Mutation-induced Structural Variation |
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(β) Inter-species Structural Differences |
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(δ) Xenobiotics-regulated Structural Variability |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Voltage-gated calcium channel alpha Cav1.2 |
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(β) Disease-specific Protein Abundances of Voltage-gated calcium channel alpha Cav1.2 |
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(γ) Species- and Tissue-specific DT Abundances |
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