Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0534 Transporter Info
Gene Name	CACNA1C
Transporter Name	Voltage-gated calcium channel alpha Cav1.2
Gene ID	775
UniProt ID	Q13936

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Nifedipine inhibits the reaction Potassium Chloride co-treated with CACNA1C protein alternative form results in increased phosphorylation of CREB1 protein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Crizotinib results in decreased activity of CACNA1C protein			[3]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Methotrexate results in increased expression of CACNA1C mRNA			[40]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Sunitinib results in decreased activity of CACNA1C protein			[3]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of CACNA1C 3' UTR			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Benzo(a)pyrene affects the methylation of CACNA1C exon			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Benzo(a)pyrene affects the methylation of CACNA1C intron			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Benzo(a)pyrene results in increased methylation of CACNA1C promoter			[30]
Regulation Mechanism				Transcription Factor Info
11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cannabinoids results in increased abundance of 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid which affects the methylation of CACNA1C gene			[23]
Regulation Mechanism				Transcription Factor Info
astragaloside A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	astragaloside A inhibits the reaction Iron-Dextran Complex results in increased abundance of Iron which results in increased expression of CACNA1C protein			[27]
Regulation Mechanism				Transcription Factor Info
Atenolol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CACNA1C gene polymorphism results in increased susceptibility to Atenolol			[28]
Regulation Mechanism				Transcription Factor Info
bardoxolone methyl	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bardoxolone methyl results in decreased activity of CACNA1C protein			[29]
Regulation Mechanism				Transcription Factor Info
benzo(e)pyrene	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	benzo(e)pyrene affects the methylation of CACNA1C intron			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	benzo(e)pyrene results in increased methylation of CACNA1C exon			[25]
Regulation Mechanism				Transcription Factor Info
bisphenol A	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant results in decreased methylation of CACNA1C gene			[31]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol A results in decreased expression of CACNA1C mRNA			[32]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	bisphenol A results in decreased methylation of CACNA1C gene			[31]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	bisphenol A results in increased expression of CACNA1C mRNA			[11]
Regulation Mechanism				Transcription Factor Info
butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	butyraldehyde results in increased expression of CACNA1C mRNA			[16]
Regulation Mechanism				Transcription Factor Info
Cadmium Chloride	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in decreased expression of CACNA1C mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cadmium Chloride results in increased expression of CACNA1C mRNA			[34]
Regulation Mechanism				Transcription Factor Info
Cannabinoids	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cannabinoids results in increased abundance of 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid which affects the methylation of CACNA1C gene			[23]
Regulation Mechanism				Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to CACNA1C gene			[37]
Regulation Mechanism				Transcription Factor Info
Deferiprone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Deferiprone inhibits the reaction Iron-Dextran Complex results in increased abundance of Iron which results in increased expression of CACNA1C protein			[27]
Regulation Mechanism				Transcription Factor Info
Diethylhexyl Phthalate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diethylhexyl Phthalate results in increased abundance of mono-(2-ethylhexyl)phthalate which results in increased methylation of CACNA1C gene			[38]
Regulation Mechanism				Transcription Factor Info
ezogabine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ezogabine affects the activity of CACNA1C protein			[17]
Regulation Mechanism				Transcription Factor Info
Fulvestrant	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant results in decreased methylation of CACNA1C gene			[31]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Fulvestrant results in increased methylation of CACNA1C gene			[31]
Regulation Mechanism				Transcription Factor Info
linsidomine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	linsidomine co-treated with Peroxynitrous Acid results in increased nitrosation of CACNA1C protein			[39]
Regulation Mechanism				Transcription Factor Info
Methapyrilene	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methapyrilene affects the methylation of CACNA1C intron			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Methapyrilene results in increased methylation of CACNA1C exon			[25]
Regulation Mechanism				Transcription Factor Info
mono-(2-ethylhexyl)phthalate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diethylhexyl Phthalate results in increased abundance of mono-(2-ethylhexyl)phthalate which results in increased methylation of CACNA1C gene			[38]
Regulation Mechanism				Transcription Factor Info
MYK-461	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	MYK-461 inhibits the reaction MYH7 gene mutant form results in decreased expression of CACNA1C mRNA			[41]
Regulation Mechanism				Transcription Factor Info
nefazodone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	nefazodone affects the activity of CACNA1C protein			[5]
Regulation Mechanism				Transcription Factor Info
Peroxynitrous Acid	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	linsidomine co-treated with Peroxynitrous Acid results in increased nitrosation of CACNA1C protein			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Peroxynitrous Acid inhibits the reaction Potassium Chloride co-treated with CACNA1C protein alternative form results in increased phosphorylation of CREB1 protein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Peroxynitrous Acid results in increased metabolism of CACNA1C protein alternative form			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Peroxynitrous Acid results in increased metabolism of CACNA1C protein alternative form which results in decreased phosphorylation of CREB1 protein			[42]
Regulation Mechanism				Transcription Factor Info
Potassium Chloride	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nifedipine inhibits the reaction Potassium Chloride co-treated with CACNA1C protein alternative form results in increased phosphorylation of CREB1 protein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Peroxynitrous Acid inhibits the reaction Potassium Chloride co-treated with CACNA1C protein alternative form results in increased phosphorylation of CREB1 protein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Potassium Chloride co-treated with CACNA1C protein alternative form results in increased phosphorylation of CREB1 protein			[42]
Regulation Mechanism				Transcription Factor Info
sodium arsenite	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite affects the methylation of CACNA1C gene			[43]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	sodium arsenite results in decreased expression of CACNA1C mRNA			[13]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	sodium arsenite results in increased expression of CACNA1C mRNA			[34]
Regulation Mechanism				Transcription Factor Info
tetrabromobisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tetrabromobisphenol A results in increased expression of CACNA1C mRNA			[20]
Regulation Mechanism				Transcription Factor Info
triphenyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	triphenyl phosphate affects the expression of CACNA1C mRNA			[44]
Regulation Mechanism				Transcription Factor Info
Valproic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid results in decreased methylation of CACNA1C gene			[45]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Valproic Acid results in increased methylation of CACNA1C gene			[46]
Regulation Mechanism				Transcription Factor Info
Verapamil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CACNA1C gene polymorphism results in increased susceptibility to Verapamil			[28]
Regulation Mechanism				Transcription Factor Info
Dietary Constituent
Calcium	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CACNA1C protein co-treated with CACNB3 protein results in increased transport of Calcium			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	CACNA1C protein results in increased transport of Calcium			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	CACNA2D4 protein binds to CACNA1C protein binds to CACNB3 protein which results in increased transport of Calcium			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	CACNA2D4 protein promotes the reaction CACNA1C protein co-treated with CACNB3 protein results in increased transport of Calcium			[35]
Regulation Mechanism				Transcription Factor Info
Iron	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	astragaloside A inhibits the reaction Iron-Dextran Complex results in increased abundance of Iron which results in increased expression of CACNA1C protein			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Deferiprone inhibits the reaction Iron-Dextran Complex results in increased abundance of Iron which results in increased expression of CACNA1C protein			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Iron-Dextran Complex results in increased abundance of Iron which results in increased expression of CACNA1C protein			[27]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Nifedipine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nifedipine inhibits the transportation of Nitrendipine by CACNA1C			[1]
Affected Drug/Substrate	Nitrendipine	Modulation Type	Inhibition
Nitrendipine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nitrendipine inhibits the transportation of Nitrendipine by CACNA1C			[1]
Affected Drug/Substrate	Nitrendipine	Modulation Type	Inhibition
Dasatinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dasatinib increases the expression of CACNA1C			[2]
Crizotinib	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Crizotinib inhibits the activity of CACNA1C			[3]
Methotrexate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methotrexate inhibits the expression of CACNA1C			[4]
Nefazodone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nefazodone affects the activity of CACNA1C			[5]
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Doxorubicin inhibits the expression of CACNA1C			[6]
Sunitinib	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sunitinib inhibits the expression of CACNA1C			[7]
Malathion	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Malathion increases the expression of CACNA1C			[8]
Rauwolfia serpentina root	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rauwolfia serpentina root inhibits the activity of CACNA1C			[9]
Propafenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Propafenone inhibits the activity of CACNA1C			[10]
Drug in Phase 3 Trial
torcetrapib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	torcetrapib increases the expression of CACNA1C			[12]
ARC029	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ARC029 inhibits the activity of CACNA1C			[22]
Drug in Phase 2 Trial
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol A increases the expression of CACNA1C			[11]
Trichloroethylene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trichloroethylene inhibits the expression of CACNA1C			[15]
Drug in Phase 1 Trial
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite inhibits the expression of CACNA1C			[13]
Retigabine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Retigabine affects the activity of CACNA1C			[17]
Environmental toxicant
Tetrabromobisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrabromobisphenol A increases the expression of CACNA1C			[20]
Mycotoxins
Aflatoxin B1	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 inhibits the expression of CACNA1C			[19]
DT Modulation2	Aflatoxin B1 results in decreased methylation of CACNA1C gene			[24]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Aflatoxin B1 results in increased methylation of CACNA1C exon			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Aflatoxin B1 results in increased methylation of CACNA1C intron			[25]
Regulation Mechanism				Transcription Factor Info
aflatoxin B2	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	aflatoxin B2 results in increased methylation of CACNA1C exon			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	aflatoxin B2 results in increased methylation of CACNA1C intron			[25]
Regulation Mechanism				Transcription Factor Info
Acute Toxic Substance
Cadmium	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium affects the expression of CACNA1C			[21]
Carcinogen
Benzo(a)pyrene	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of CACNA1C			[14]
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in decreased expression of CACNA1C mRNA			[33]
Regulation Mechanism				Transcription Factor Info
Arsenic	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arsenic affects the methylation of CACNA1C gene			[26]
Regulation Mechanism				Transcription Factor Info
Health and Environmental Toxicant
Butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Butyraldehyde increases the expression of CACNA1C			[16]
Lead	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lead affects the expression of CACNA1C			[18]

References
1	Diethyl 3,6-dihydro-2,4-dimethyl-2,6-methano-1,3-benzothiazocine-5,11- dicarboxylates as calcium entry antagonists: new conformationally restrained analogues of Hantzsch 1,4-dihydropyridines related to nitrendipine as probes for receptor-site conformation. J Med Chem. 1987 Apr;30(4):690-5.
2	Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
3	Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55.
4	Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
5	Evaluation of nefazodone-induced cardiotoxicity in human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2016 Apr 1;296:42-53.
6	Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
7	Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761.
8	Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259.
9	Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716.
10	Optimization of propafenone analogues as antimalarial leads. J Med Chem. 2011 Nov 10;54(21):7477-85.
11	Microarray analysis of bisphenol A-induced changes in gene expression in human oral epithelial cells. Acta Biochim Biophys Sin (Shanghai). 2007 Nov;39(11):879-84.
12	Mechanisms underlying off-target effects of the cholesteryl ester transfer protein inhibitor torcetrapib involve L-type calcium channels. J Hypertens. 2010 Aug;28(8):1676-86.
13	Altered gene expression by low-dose arsenic exposure in humans and cultured cardiomyocytes: assessment by real-time PCR arrays. Int J Environ Res Public Health. 2011 Jun;8(6):2090-108.
14	Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
15	Disruption of cardiogenesis in human embryonic stem cells exposed to trichloroethylene. Environ Toxicol. 2016 Nov;31(11):1372-1380.
16	Integrated analysis of microRNA and mRNA expression profiles highlights aldehyde-induced inflammatory responses in cells relevant for lung toxicity. Toxicology. 2015 Aug 6;334:111-21.
17	Modulation of the heart's electrical properties by the anticonvulsant drug retigabine. Toxicol Appl Pharmacol. 2017 Aug 15;329:309-317.
18	RNA-Seq of Human Neural Progenitor Cells Exposed to Lead (Pb) Reveals Transcriptome Dynamics, Splicing Alterations and Disease Risk Associations. Toxicol Sci. 2017 Sep 1;159(1):251-265.
19	Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297.
20	Pathways involved in the human vascular Tetrabromobisphenol A response: Calcium and potassium channels and nitric oxide donors. Toxicology. 2022 Mar 30;470:153158.
21	Cardiac Development in the Presence of Cadmium: An in Vitro Study Using Human Embryonic Stem Cells and Cardiac Organoids. Environ Health Perspect. 2022 Nov;130(11):117002.
22	Dihydropyrimidines: novel calcium antagonists with potent and long-lasting vasodilative and antihypertensive activity. J Med Chem. 1989 Oct;32(10):2399-406.
23	Cannabinoid exposure and altered DNA methylation in rat and human sperm. Epigenetics. 2018;13(12):1208-1221.
24	Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma. Toxicology. 2016 Mar 28;350-352:31-9.
25	Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018;121:214-223.
26	Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106.
27	Astragaloside IV protects against retinal iron overload toxicity through iron regulation and the inhibition of MAPKs and NF-B activation. Toxicol Appl Pharmacol. 2021;410:115361.
28	CACNA1C gene polymorphisms, cardiovascular disease outcomes, and treatment response. Circ Cardiovasc Genet. 2009 Aug;2(4):362-70.
29	Characterization of the Potent, Selective Nrf2 Activator, 3-(Pyridin-3-Ylsulfonyl)-5-(Trifluoromethyl)-2H-Chromen-2-One, in Cellular and In Vivo Models of Pulmonary Oxidative Stress. J Pharmacol Exp Ther. 2017;363(1):114-125.
30	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
31	DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019;11(1):138.
32	Effects of bisphenol A on human umbilical arteries. Environ Sci Pollut Res Int. 2023;30(10):27670-27681.
33	Cadmium acute exposure induces metabolic and transcriptomic perturbations in human mature adipocytes. Toxicology. 2022;470:153153.
34	High-Throughput Transcriptomics of Nontumorigenic Breast Cells Exposed to Environmentally Relevant Chemicals. Environ Health Perspect. 2024;132(4):47002.
35	Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit. Mol Pharmacol. 2002;62(3):485-96.
36	Transcript scanning reveals novel and extensive splice variations in human l-type voltage-gated calcium channel, Cav1.2 alpha1 subunit. J Biol Chem. 2004;279(43):44335-43.
37	Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines. Exp Cell Res. 2017;353(1):6-15.
38	Effect of prenatal exposure to phthalates on epigenome-wide DNA methylations in cord blood and implications for fetal growth: The Hokkaido Study on Environment and Children's Health. Sci Total Environ. 2021;783:147035.
39	Nitrotyrosylation of Ca2+ channels prevents c-Src kinase regulation of colonic smooth muscle contractility in experimental colitis. J Pharmacol Exp Ther. 2007;322(3):948-56.
40	Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011;32(5):965-76.
41	Human engineered cardiac tissue model of hypertrophic cardiomyopathy recapitulates key hallmarks of the disease and the effect of chronic mavacamten treatment. Front Bioeng Biotechnol. 2023;11:1227184.
42	The effect of tyrosine nitration of L-type Ca2+ channels on excitation-transcription coupling in colonic inflammation. Br J Pharmacol. 2010;159(6):1226-35.
43	Microarray dataset of transient and permanent DNA methylation changes in HeLa cells undergoing inorganic arsenic-mediated epithelial-to-mesenchymal transition. Data Brief. 2017;13:6-9.
44	Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60-69 Years of Age: Evidence from the China BAPE Study. Environ Health Perspect. 2023;131(4):47009.
45	Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
46	Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.

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Detail Information of Exogenous Modulation

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