Detail Information of Mutation-induced Spatial Variation

General Information of Drug Transporter (DT)
DT ID	DTD0534 Transporter Info
Gene Name	CACNA1C
Transporter Name	Voltage-gated calcium channel alpha Cav1.2
Gene ID	775
UniProt ID	Q13936
Mutation-induced Structural Variation (MSV) of This DT
Click to Save PDB File in TXT Format	PDB ID		7L8V
	Expression System		Escherichia coli
	Method		NMR
	Resolution		N.A.
	Corresponding chain		A
	Mutation Site(s)		D21A; D23A; D25A; E32Q; D57A; D59A; N61A; E68Q		[1]
	Structure Details		Click to Show/Hide the Details
Modeling Method	NMR
Publication year	2022
Closely Related Crystal Structure of This MSV
PDB ID	Scanning Method	Resolution	Mutation Sites	Details	Ref
7L8V	NMR	N.A.	D21A; D23A; D25A; E32Q; D57A; D59A; N61A; E68Q	Show Detail	[1]
Structure
Expression System	Escherichia coli
References
1	Half-calcified calmodulin promotes basal activity and inactivation of the L-type calcium channel Ca(V)1.2. J Biol Chem. 2022;298(12):102701.

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