Modelled Stucture
Method:Homology modeling
Teplate PDB:5GJV_A
Identity:69.088%
Minimized Score:-2785.464
Detail: Structure Info
Detail Information of Inter-species Structural Difference
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0534 Transporter Info | ||||
| Gene Name | CACNA1C | ||||
| Protein Name | Voltage-gated calcium channel alpha Cav1.2 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| 3D Structure |
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| Inter-species Structural Differences (ISD) | |||||
| Mus musculus (Mouse) | |||||
| Gene Name | Cacna1c | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure |
Method:Homology modeling Teplate PDB:5GJV_A Sequence Length:1667 Identity:70% |
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| Click to Save PDB File in TXT Format | |||||
| Performance | Minimized Score | -2776.055 kcal/mol | |||
| Ramachandra Favored | Poor |
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| QMEANBrane Quality | Medium |
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| Ramachandran Plot |
Ramz Z Score:-1.49 ±0.19 Residues in Favored Region:1576 Ramachandran favored:94.65% Number of Outliers:21 Ramachandran outliers:1.26% |
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| Click to Save Ramachandran Plot in PNG Format | |||||
| Local Quality |
QMEANBrane Score:0.76 |
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| Click to Save Local Quality Plot in PNG Format | |||||
| Rattus norvegicus (Rat) | |||||
| Gene Name | Cacna1c | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure |
Method:Homology modeling Teplate PDB:5GJV_A Sequence Length:1666 Identity:68.947% |
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| Click to Save PDB File in TXT Format | |||||
| Performance | Minimized Score | -2840.027 kcal/mol | |||
| Ramachandra Favored | Poor |
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| QMEANBrane Quality | Medium |
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| Ramachandran Plot |
Ramz Z Score:-2.02 ±0.19 Residues in Favored Region:1578 Ramachandran favored:94.83% Number of Outliers:23 Ramachandran outliers:1.38% |
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| Click to Save Ramachandran Plot in PNG Format | |||||
| Local Quality |
QMEANBrane Score:0.76 |
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| Click to Save Local Quality Plot in PNG Format | |||||
| Experimental Structures of This Model Oganism | |||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref |
| 1VYT | X-ray | 2.6 Å | Escherichia coli | [ 1] | |
| Structure | |||||
| Click to Save PDB File in TXT Format | |||||
| Corresponding chain | E/F | ||||
| Sequence Length | 452-476 | Mutation | No | ||
| Oryctolagus cuniculus (Rabbit) | |||||
| Gene Name | CACNA1C | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure |
Method:Homology modeling Teplate PDB:5GJV_A Sequence Length:1667 Identity:70.018% |
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| Click to Save PDB File in TXT Format | |||||
| Performance | Minimized Score | -2802.909 kcal/mol | |||
| Ramachandra Favored | Poor |
||||
| QMEANBrane Quality | Medium |
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| Ramachandran Plot |
Ramz Z Score:-1.95 ±0.19 Residues in Favored Region:1579 Ramachandran favored:94.83% Number of Outliers:26 Ramachandran outliers:1.56% |
||||
| Click to Save Ramachandran Plot in PNG Format | |||||
| Local Quality |
QMEANBrane Score:0.76 |
||||
| Click to Save Local Quality Plot in PNG Format | |||||
| Experimental Structures of This Model Oganism | |||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref |
| 4DEY | X-ray | 1.95 Å | Escherichia coli | [ 2] | |
| Structure | |||||
| Click to Save PDB File in TXT Format | |||||
| Corresponding chain | B | ||||
| Sequence Length | 435-539 | Mutation | No | ||
| 6CTB | NMR | N.A. | pBR322 based IG-lambda expression vector | [ 3] | |
| Structure | |||||
| Click to Save PDB File in TXT Format | |||||
| Corresponding chain | B | ||||
| Sequence Length | 1644-1668 | Mutation | No | ||
| References | |||||
| 1 | Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels. Nature. 2004 Jun 10;429(6992):675-80. | ||||
| 2 | The role of a voltage-dependent Ca2+ channel intracellular linker: a structure-function analysis. J Neurosci. 2012 May 30;32(22):7602-13. | ||||
| 3 | RCSB PDB: apo-Calmodulin Bound to Calcium Voltage Gated Channel 1.2 IQ-Motif. | ||||
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