Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0534 Transporter Info
Gene Name CACNA1C
Transporter Name Voltage-gated calcium channel alpha Cav1.2
Gene ID
775
UniProt ID
Q13936

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 6 TF(s) Regulating This DT

        ATF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [1]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-3 Transcription Factor Info

Tissue

 Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        BACH1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of CACNA1C gene in breast cancer bone metastasis condition [2]

TF Protein Name

 Transcription regulator protein BACH1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription regulator protein BACH1 (BACH1) has been reported to activate the transcription of CACNA1C gene in breast cancer bone metastasis condition, which leads to an increased expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [3]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Bone

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of CACNA1C gene in brain neuroblastoma condition [4]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Studied Phenotype

 Brain neuroblastoma [ICD11: 2A00.11]

Tissue

 Brain

Related DT Changes

 Up regulating

Experimental Material

 Human neuroblastoma cells (SH-SY5Y)

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) has been reported to activate the transcription of CACNA1C gene in brain neuroblastoma condition, which leads to an increased expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        FOSL1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [5]

TF Protein Name

 Fos-related antigen 1 Transcription Factor Info

Tissue

 Bone marrow; Breast; Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Fos-related antigen 1 (FOSL1) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        NFE2L2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of CACNA1C gene in colon cancer condition [6]

TF Protein Name

 Nuclear factor erythroid 2-related factor 2 Transcription Factor Info

Studied Phenotype

 Colon cancer [ICD11: 2B90]

Tissue

 Colon

Related DT Changes

 Down regulating

Experimental Material

 Human colon carcinoma cells (RKO)

Detailed Description

 Nuclear factor erythroid 2-related factor 2 (NFE2L2) has been reported to repress the transcription of CACNA1C gene in colon cancer condition, which leads to a decreased expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 6 TF(s) Regulating This DT

        ARNT 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [7]

TF Protein Name

 Aryl hydrocarbon receptor nuclear translocator Transcription Factor Info

Tissue

 Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Aryl hydrocarbon receptor nuclear translocator (ARNT) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        ASCL1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [5]

TF Protein Name

 Achaete-scute homolog 1 Transcription Factor Info

Tissue

 Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Achaete-scute homolog 1 (ASCL1) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        EPAS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [7]

TF Protein Name

 Endothelial PAS domain-containing protein 1 Transcription Factor Info

Tissue

 Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Endothelial PAS domain-containing protein 1 (EPAS1) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        MYC 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of CACNA1C gene in medulloblastoma condition [8]

TF Protein Name

 Myc proto-oncogene protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Myc proto-oncogene protein (MYC) has been reported to repress the transcription of CACNA1C gene in medulloblastoma condition, which leads to a decreased expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

       Transcriptional Phenomenon2

 Activation of CACNA1C gene in brain neuroblastoma condition [4]

TF Protein Name

 Myc proto-oncogene protein Transcription Factor Info

Studied Phenotype

 Brain neuroblastoma [ICD11: 2A00.11]

Tissue

 Brain

Related DT Changes

 Up regulating

Experimental Material

 Human neuroblastoma cells (SH-SY5Y)

Detailed Description

 Myc proto-oncogene protein (MYC) has been reported to activate the transcription of CACNA1C gene in brain neuroblastoma condition, which leads to an increased expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        TCF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [1]

TF Protein Name

 Transcription factor E2-alpha Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2-alpha (TCF3) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        TCF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of CACNA1C gene in glioblastoma multiforme condition [9]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to activate the transcription of CACNA1C gene in glioblastoma multiforme condition, which leads to an increased expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

      Class1.3: Basic helix-span-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TFAP2A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1C gene in MCF7 cells [10]

TF Protein Name

 Transcription factor AP-2-alpha Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor AP-2-alpha (TFAP2A) has been reported to bind to the transcription of CACNA1C gene in MCF7 cells, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 6 TF(s) Regulating This DT

        AR 

Click to Show/Hide to Show 3 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1C gene in prostate cancer condition [11]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of CACNA1C gene in prostate cancer condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

       Transcriptional Phenomenon2

 Direct binding to CACNA1C gene [12]

TF Protein Name

 Androgen receptor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of CACNA1C gene in . condition, which leads to a affected expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

       Transcriptional Phenomenon3

 Binding to CACNA1C gene in prostate cancer condition [13]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of CACNA1C gene in prostate cancer condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1C gene in health condition [14]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of CACNA1C gene in health condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        NR2F2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [5]

TF Protein Name

 COUP transcription factor 2 Transcription Factor Info

Tissue

 Bone marrow; Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 COUP transcription factor 2 (NR2F2) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        NR3C1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of CACNA1C gene in ER(-) breast cancer condition [15]

TF Protein Name

 Glucocorticoid receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Glucocorticoid receptor (NR3C1) has been reported to activate the transcription of CACNA1C gene in ER(-) breast cancer condition, which leads to an increased expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        PPARG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [1]

TF Protein Name

 Peroxisome proliferator-activated receptor gamma Transcription Factor Info

Tissue

 Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Peroxisome proliferator-activated receptor gamma (PPARG) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        VDR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of CACNA1C gene in multiple sclerosis condition [16]

TF Protein Name

 Vitamin D3 receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Vitamin D3 receptor (VDR) has been reported to activate the transcription of CACNA1C gene in multiple sclerosis condition, which leads to an increased expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GATA2 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1C gene in megakaryocytes condition [17]

TF Protein Name

 Endothelial transcription factor GATA-2 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Endothelial transcription factor GATA-2 (GATA2) has been reported to bind to the transcription of CACNA1C gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

       Transcriptional Phenomenon2

 Binding to CACNA1C gene in health condition [18]

TF Protein Name

 Endothelial transcription factor GATA-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Endothelial transcription factor GATA-2 (GATA2) has been reported to bind to the transcription of CACNA1C gene in health condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 8 TF(s) Regulating This DT

        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [3]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        EGR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1C gene in erythroleukemia condition [19]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of CACNA1C gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        EGR2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [3]

TF Protein Name

 E3 SUMO-protein ligase EGR2 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 E3 SUMO-protein ligase EGR2 (EGR2) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        KLF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [7]

TF Protein Name

 Krueppel-like factor 1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 1 (KLF1) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        KLF9 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [7]

TF Protein Name

 Krueppel-like factor 9 Transcription Factor Info

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 9 (KLF9) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [5]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        WT1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of CACNA1C gene in podocyte condition [20]

TF Protein Name

 Wilms tumor protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Wilms tumor protein (WT1) has been reported to activate the transcription of CACNA1C gene in podocyte condition, which leads to an increased expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [1]

TF Protein Name

 Zinc finger protein 263 Transcription Factor Info

Tissue

 Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 263 (ZNF263) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        PBX3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [5]

TF Protein Name

 Pre-B-cell leukemia transcription factor 3 Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 7 TF(s) Regulating This DT

        E2F1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1C gene in MCF7 cells [10]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor E2F1 (E2F1) has been reported to bind to the transcription of CACNA1C gene in MCF7 cells, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

       Transcriptional Phenomenon2

 Direct binding to CACNA1C gene [3]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Tissue

 Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F1 (E2F1) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        E2F6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [7]

TF Protein Name

 Transcription factor E2F6 Transcription Factor Info

Tissue

 Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F6 (E2F6) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        FOXA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [5]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Tissue

 Breast; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [1]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Tissue

 Embryo; Liver; Lung; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        FOXM1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of CACNA1C gene in breast cancer condition [21]

TF Protein Name

 Forkhead box protein M1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Forkhead box protein M1 (FOXM1) has been reported to activate the transcription of CACNA1C gene in breast cancer condition, which leads to an increased expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        FOXP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of CACNA1C gene in embryonic stem cell condition [22]

TF Protein Name

 Forkhead box protein P1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Forkhead box protein P1 (FOXP1) has been reported to repress the transcription of CACNA1C gene in embryonic stem cell condition, which leads to a decreased expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        FOXP2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1C gene in health condition [23]

TF Protein Name

 Forkhead box protein P2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Forkhead box protein P2 (FOXP2) has been reported to bind to the transcription of CACNA1C gene in health condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 7 TF(s) Regulating This DT

        ELK3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [7]

TF Protein Name

 ETS domain-containing protein Elk-3 Transcription Factor Info

Tissue

 Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 ETS domain-containing protein Elk-3 (ELK3) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        ERG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [12]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcriptional regulator ERG (ERG) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        ETV1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [5]

TF Protein Name

 ETS translocation variant 1 Transcription Factor Info

Tissue

 GastroIntestine tract; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 ETS translocation variant 1 (ETV1) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        FLI1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1C gene in megakaryocytes condition [17]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of CACNA1C gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

       Transcriptional Phenomenon2

 Direct binding to CACNA1C gene [1]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [3]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Liver; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        MYB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [3]

TF Protein Name

 Transcriptional activator Myb Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional activator Myb (MYB) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [1]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Tissue

 Adrenal gland; Blood; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor PU.1 (SPI1) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

      Class3.7: ARID domain factors

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        KDM5B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene [7]

TF Protein Name

 Lysine-specific demethylase 5B Transcription Factor Info

Tissue

 Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Lysine-specific demethylase 5B (KDM5B) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

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        NFAT5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of CACNA1C gene in health condition [24]

TF Protein Name

 Nuclear factor of activated T-cells 5 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Heart

Related DT Changes

 Up regulating

Experimental Material

 Mouse embryo cardiomyocyte cells (P19cl6)

Detailed Description

 Nuclear factor of activated T-cells 5 (NFAT5) has been reported to activate the transcription of CACNA1C gene in health condition, which leads to an increased expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

      Class6.2: STAT domain factors

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        STAT3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1C gene in glioblastoma multiforme condition [9]

TF Protein Name

 Signal transducer and activator of transcription 3 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Signal transducer and activator of transcription 3 (STAT3) has been reported to bind to the transcription of CACNA1C gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

      Class6.3: p53 domain factors

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        TP53 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1C gene in HFKS condition [25]

TF Protein Name

 Cellular tumor antigen p53 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of CACNA1C gene in HFKS condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

       Transcriptional Phenomenon2

 Binding to CACNA1C gene in health condition [26]

TF Protein Name

 Cellular tumor antigen p53 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of CACNA1C gene in health condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        RUNX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1C gene in megakaryocytes condition [17]

TF Protein Name

 Runt-related transcription factor 1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of CACNA1C gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

        RUNX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of CACNA1C gene in prostate cancer condition [27]

TF Protein Name

 Runt-related transcription factor 2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of CACNA1C gene in prostate cancer condition, which leads to an increased expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SMAD4 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of CACNA1C gene in human embryonic stem cells (hESCs) condition [28]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of CACNA1C gene in human embryonic stem cells (hESCs) condition, which leads to an increased expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

       Transcriptional Phenomenon2

 Binding to CACNA1C gene in epithelial ovarian cancer condition [29]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of CACNA1C gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav1.2.

TF Superclass10: Yet undefined DNA-binding domains

      Class10.1: Other factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        ZNF804A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1C gene in bipolar affective disorder condition [30]

TF Protein Name

 Zinc finger protein 804A Transcription Factor Info

Studied Phenotype

 Bipolar affective disorder [ICD11: 6A60]

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Experimental Material

 human peripheral blood mononuclear cell isolates

Detailed Description

 Zinc finger protein 804A (ZNF804A) can directly bind to the CACNA1C gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav1.2.
References
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3 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
4 Methamphetamine acutely inhibits voltage-gated calcium channels but chronically up-regulates L-type channels. J Neurochem. 2015 Jul;134(1):56-65.
5 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
6 Molecular and genomic approach for understanding the gene-environment interaction between Nrf2 deficiency and carcinogenic nickel-induced DNA damage. Oncol Rep. 2012 Dec;28(6):1959-67.
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8 Silencing of thrombospondin-1 is critical for myc-induced metastatic phenotypes in medulloblastoma. Cancer Res. 2010;70(20):8199-210.
9 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
10 A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res. 2006;16(12):1585-95.
11 Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor. Oncotarget. 2012;3(2):183-94.
12 Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
13 Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
14 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
15 Activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancer. Cancer Res. 2011;71(20):6360-70.
16 Molecular network of chromatin immunoprecipitation followed by deep sequencing-based vitamin D receptor target genes. Mult Scler. 2013;19(8):1035-45.
17 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
18 Epigenetically coordinated GATA2 binding is necessary for endothelium-specific endomucin expression. EMBO J. 2011;30(13):2582-95.
19 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
20 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
21 FOXM1 cistrome predicts breast cancer metastatic outcome better than FOXM1 expression levels or tumor proliferation index. Breast Cancer Res Treat. 2015;154(1):23-32.
22 An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 2011;147(1):132-46.
23 Microfluidic affinity and ChIP-seq analyses converge on a conserved FOXP2-binding motif in chimp and human, which enables the detection of evolutionarily novel targets. Nucleic Acids Res. 2013;41(12):5991-6004.
24 NFAT5-mediated CACNA1C expression is critical for cardiac electrophysiological development and maturation. J Mol Med (Berl). 2016 Sep;94(9):993-1002.
25 Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
26 Characterization of genome-wide p53-binding sites upon stress response. Nucleic Acids Res. 2008;36(11):3639-54.
27 Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.
28 Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol. 2011;357(2):492-504.
29 ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.
30 The effect of psychosis associated CACNA1C, and its epistasis with ZNF804A, on brain function. Genes Brain Behav. 2019 Apr;18(4):e12510.

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