| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0532 | ||||
| Gene Name | KCNT1 | ||||
| Protein Name | Potassium channel subfamily T member 1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:5U70_A Identity:86.095% Minimized Score:-2538.384 kcal/mol Detail: Structure Info |
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| Synonyms | EIEE14; ENFL5; KCNT1; KCa4.1; KIAA1422; SLACK; Slo2.2; bA100C15.2 | ||||
| DT Family | Voltage-Gated Ion Channel (VIC) Superfamily ; | ||||
| Tissue Specificity | Highest expression in liver, brain and spinalcord. Lowest expression in skeletal muscle. | ||||
| Function | This potassium channel transporter may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. | ||||
| Endogenous Substrate(s) | Potassium ions | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Potassium channel subfamily T member 1 |
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(β) Cell Distribution Level of Potassium channel subfamily T member 1 |
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(γ) Organelle Distribution Level of Potassium channel subfamily T member 1 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Potassium channel subfamily T member 1 |
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(δ) Epigenetic Regulation of Potassium channel subfamily T member 1 |
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(ε) Exogenous Modulation of Potassium channel subfamily T member 1 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Potassium channel subfamily T member 1 |
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(β) Disease-specific Protein Abundances of Potassium channel subfamily T member 1 |
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(γ) Species- and Tissue-specific DT Abundances |
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