Detail Information of DT Wildtype Structure
| General Information of Drug Transporter (DT) | ||||||
|---|---|---|---|---|---|---|
| DT ID | DTD0532 Transporter Info | |||||
| Gene Name | KCNT1 | |||||
| Transporter Name | Potassium channel subfamily T member 1 | |||||
| Gene ID | ||||||
| UniProt ID | ||||||
| Modelled Structures of This DT | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Detail Information of Structural Model | ||||||
| Method | Homology modeling | |||||
| Template PDB | 5U70_A | Identity | 86.095% | |||
| Performance | Minimized Score | -2538.384 kcal/mol | ||||
| Ramachandra Favored | Medium |
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| QMEANBrane Quality | Medium |
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| Ramachandran Plot |
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| Click to Save Ramachandran Plot in PNG Format | ||||||
| Ramz Z Score | -0.67 ±0.23 | |||||
| Residues in Favored Region | 1187 | Ramachandran favored | 96.66% | |||
| Number of Outliers | 6 | Ramachandran outliers | 0.49% | |||
| Local Quality |
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| Click to Save Local Quality Plot in PNG Format | ||||||
| QMEANBrane Score | 0.75 | |||||
| AlphaFold Protein Structure Database | ||||||
| SWISS-MODEL Database | ||||||
| Experimental Structures of This DT | ||||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref | |
| 8HIR | EM | 3.18 Å | Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/B/C/D | |||||
| Sequence Length | 23-1230 | Mutation | No | |||
| 8HK6 | EM | 2.64 Å | Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/B/C/D | |||||
| Sequence Length | 23-1230 | Mutation | No | |||
| 8HKF | EM | 2.66 Å | Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/B/C/D | |||||
| Sequence Length | 23-1230 | Mutation | No | |||
| 8HKK | EM | 2.84 Å | Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/B/C/D | |||||
| Sequence Length | 23-1230 | Mutation | No | |||
| 8HKM | EM | 2.95 Å | Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/B/C/D | |||||
| Sequence Length | 23-1230 | Mutation | No | |||
| 8HKQ | EM | 2.9 Å | Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/B/C/D | |||||
| Sequence Length | 23-1230 | Mutation | No | |||
| References | ||||||
| 1 | Structural basis of human Slo2.2 channel gating and modulation. Cell Rep. 2023;42(8):112858. | |||||
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