General Information of Drug Transporter (DT)
DT ID	DTD0532 Transporter Info
Gene Name	KCNT1
Protein Name	Potassium channel subfamily T member 1
Gene ID	57582
UniProt ID	Q9P2C5
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs10776850
Site of GPD	chr9:135785692 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	T>A
Minor Allele Frequency	A=0.1809/906 (Global)
Allele A	Click to Show/Hide the Full List of Affected Drugs:           2 Drugs in Total
Antiepileptics	N.A.	Myotonic Disorders	Allele A is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele T.		[ 1]
Antiepileptics	N.A.	Epilepsy	Irrelevant to the drug response in patients (compare with allele T)		[ 1]
Genetic Polymorphism	rs496503
Site of GPD	chr9:135705128 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>A
Minor Allele Frequency	G=0.1620/320 (Global)
Allele A	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Antiepileptics	N.A.	Myotonic Disorders	Allele A is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele G.		[ 1]
Genetic Polymorphism	rs546120
Site of GPD	chr9:135703102 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>A / G>C / G>T
Minor Allele Frequency	G=0.4720/934 (Global)
Allele A	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Antiepileptics	N.A.	Myotonic Disorders	Allele A is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele G.		[ 1]
Genetic Polymorphism	rs7855716
Site of GPD	chr9:135725655 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>C / G>T
Minor Allele Frequency	G=0.7620/1507 (Global)
Allele C	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Antiepileptics	N.A.	Myotonic Disorders	Allele C is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele G.		[ 1]
Genetic Polymorphism	rs1537416
Site of GPD	chr9:135725457 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	T>C
Minor Allele Frequency	T=0.5420/1072 (Global)
Allele C	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Antiepileptics	N.A.	Myotonic Disorders	Allele C is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele T.		[ 1]
Genetic Polymorphism	rs10735239
Site of GPD	chr9:135752357 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	T>C
Minor Allele Frequency	T=0.4740/938 (Global)
Allele C	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Antiepileptics	N.A.	Myotonic Disorders	Allele C is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele T.		[ 1]
Genetic Polymorphism	rs755722
Site of GPD	chr9:135739808 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	C>T
Minor Allele Frequency	C=0.6150/1217 (Global)
Allele C	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Antiepileptics	N.A.	Myotonic Disorders	Allele C is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele T.		[ 1]
Genetic Polymorphism	rs1165016
Site of GPD	chr9:135714078 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	C>G / C>T
Minor Allele Frequency	C=0.3720/736 (Global)
Allele C	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Antiepileptics	N.A.	Myotonic Disorders	Allele C is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele T.		[ 1]
Genetic Polymorphism	rs487750
Site of GPD	chr9:135711894 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	C>G / C>T
Minor Allele Frequency	C=0.4950/979 (Global)
Allele C	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Antiepileptics	N.A.	Myotonic Disorders	Allele C is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele T.		[ 1]
Genetic Polymorphism	rs498618
Site of GPD	chr9:135724120 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	A>G / A>T
Minor Allele Frequency	A=0.3320/657 (Global)
Allele A	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Antiepileptics	N.A.	Myotonic Disorders	Allele A is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele G.		[ 1]
Genetic Polymorphism	rs498974
Site of GPD	chr9:135715705 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	A>G / A>T
Minor Allele Frequency	A=0.5770/1141 (Global)
Allele A	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Antiepileptics	N.A.	Myotonic Disorders	Allele A is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele T.		[ 1]
Genetic Polymorphism	rs10776845
Site of GPD	chr9:135778130 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	C>A
Minor Allele Frequency	C=0.7390/1462 (Global)
Allele A	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Antiepileptics	N.A.	Myotonic Disorders	Allele A is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele C.		[ 1]
Genetic Polymorphism	rs10858173
Site of GPD	chr9:135789055 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	T>A / T>C
Minor Allele Frequency	T=0.6750/1335 (Global)
Allele C	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Antiepileptics	N.A.	Myotonic Disorders	Allele C is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele T.		[ 1]
Genetic Polymorphism	rs10118746
Site of GPD	chr9:135761806 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	A>G
Minor Allele Frequency	A=0.6650/1316 (Global)
Allele A	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Antiepileptics	N.A.	Myotonic Disorders	Allele A is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele G.		[ 1]
Genetic Polymorphism	rs11103167
Site of GPD	chr9:135756318 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	T>C
Minor Allele Frequency	T=0.8640/1709 (Global)
Allele C	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Antiepileptics	N.A.	Myotonic Disorders	Allele C is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele T.		[ 1]
Genetic Polymorphism	rs1318383
Site of GPD	chr9:135776227 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	A>G / A>T
Minor Allele Frequency	A=0.2460/486 (Global)
Allele A	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Antiepileptics	N.A.	Myotonic Disorders	Allele A is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele G.		[ 1]
Genetic Polymorphism	rs11103182
Site of GPD	chr9:135771950 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>A / G>T
Minor Allele Frequency	G=0.3570/706 (Global)
Allele G	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Antiepileptics	N.A.	Myotonic Disorders	Allele G is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele T.		[ 1]
References
1	Gene-wide tagging study of the association between KCNT1 polymorphisms and the susceptibility and efficacy of genetic generalized epilepsy in Chinese population. CNS Neurosci Ther. 2014 Feb;20(2):140-6.

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