| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0519 | ||||
| Gene Name | CACNA1B | ||||
| Protein Name | Voltage-gated calcium channel alpha Cav2.2 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:6JPA_A Identity:48.763% Minimized Score:-1470.617 kcal/mol Detail: Structure Info |
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| Synonyms | BIII; Brain calcium channel III; CACH5; CACNA1B; CACNL1A5; CACNN; Calcium channel, L type, alpha-1 polypeptide isoform 5; Cav2.2; DYT23; Voltage-dependent N-type calcium channel subunit alpha-1B; Voltage-gated calcium channel subunit alpha Cav2.2 | ||||
| DT Family | Voltage-Gated Ion Channel (VIC) Superfamily ; | ||||
| Tissue Specificity | Isoform Alpha-1b-1 and isoform Alpha-1b-2 areexpressed in the central nervous system, but not in skeletalmuscle or aorta. | ||||
| Function | This voltage-sensitive transporter mediates the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (AC P01522). They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. | ||||
| Endogenous Substrate(s) | Ca2+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Voltage-gated calcium channel alpha Cav2.2 |
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(β) Cell Distribution Level of Voltage-gated calcium channel alpha Cav2.2 |
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(γ) Organelle Distribution Level of Voltage-gated calcium channel alpha Cav2.2 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Voltage-gated calcium channel alpha Cav2.2 |
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(γ) Transcriptional Regulation of Voltage-gated calcium channel alpha Cav2.2 |
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(δ) Epigenetic Regulation of Voltage-gated calcium channel alpha Cav2.2 |
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(ε) Exogenous Modulation of Voltage-gated calcium channel alpha Cav2.2 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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(δ) Xenobiotics-regulated Structural Variability |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Voltage-gated calcium channel alpha Cav2.2 |
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(β) Disease-specific Protein Abundances of Voltage-gated calcium channel alpha Cav2.2 |
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(γ) Species- and Tissue-specific DT Abundances |
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