Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0519 Transporter Info
Gene Name CACNA1B
Transporter Name Voltage-gated calcium channel alpha Cav2.2
Gene ID
774
UniProt ID
Q00975

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        TCF21 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of CACNA1B gene in adrenocortical carcinoma condition [1]

TF Protein Name

 Transcription factor 21 Transcription Factor Info

Studied Phenotype

 Adrenocortical carcinoma [ICD11: 2D11.0]

Tissue

 Adrenal gland

Related DT Changes

 Down regulating

Experimental Material

 Human adrenal cortex carcinoma cells (NCI-H295R)

Detailed Description

 Transcription factor 21 (TCF21) has been reported to repress the transcription of CACNA1B gene in adrenocortical carcinoma condition, which leads to a decreased expression of the drug transporter Voltage-gated calcium channel alpha Cav2.2.

        TCF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of CACNA1B gene in glioblastoma multiforme condition [2]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to activate the transcription of CACNA1B gene in glioblastoma multiforme condition, which leads to an increased expression of the drug transporter Voltage-gated calcium channel alpha Cav2.2.

        TWIST1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of CACNA1B gene in health condition [3]

TF Protein Name

 Twist-related protein 1 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Blood

Related DT Changes

 Down regulating

Experimental Material

 C57BL/6J-Ly5.1 congenic mice

Detailed Description

 Twist-related protein 1 (TWIST1) has been reported to repress the transcription of CACNA1B gene in health condition, which leads to a decreased expression of the drug transporter Voltage-gated calcium channel alpha Cav2.2.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        AR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1B gene in prostate cancer condition [4]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of CACNA1B gene in prostate cancer condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav2.2.

        PPARD 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of CACNA1B gene in myofibroblasts condition [5]

TF Protein Name

 Peroxisome proliferator-activated receptor delta Transcription Factor Info

Related DT Changes

 Down regulating

Detailed Description

 Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of CACNA1B gene in myofibroblasts condition, which leads to a decreased expression of the drug transporter Voltage-gated calcium channel alpha Cav2.2.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        EGR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1B gene in erythroleukemia condition [6]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of CACNA1B gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav2.2.

        WT1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of CACNA1B gene in podocyte condition [7]

TF Protein Name

 Wilms tumor protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Wilms tumor protein (WT1) has been reported to activate the transcription of CACNA1B gene in podocyte condition, which leads to an increased expression of the drug transporter Voltage-gated calcium channel alpha Cav2.2.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        PBX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of CACNA1B gene in ovarian cancer condition [8]

TF Protein Name

 Pre-B-cell leukemia transcription factor 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Pre-B-cell leukemia transcription factor 1 (PBX1) has been reported to activate the transcription of CACNA1B gene in ovarian cancer condition, which leads to an increased expression of the drug transporter Voltage-gated calcium channel alpha Cav2.2.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        FOXP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of CACNA1B gene in embryonic stem cell condition [9]

TF Protein Name

 Forkhead box protein P1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Forkhead box protein P1 (FOXP1) has been reported to repress the transcription of CACNA1B gene in embryonic stem cell condition, which leads to a decreased expression of the drug transporter Voltage-gated calcium channel alpha Cav2.2.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        FLI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1B gene in megakaryocytes condition [10]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of CACNA1B gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav2.2.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        SMAD3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of CACNA1B gene in HESC condition [11]

TF Protein Name

 Mothers against decapentaplegic homolog 3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 3 (SMAD3) has been reported to activate the transcription of CACNA1B gene in HESC condition, which leads to an increased expression of the drug transporter Voltage-gated calcium channel alpha Cav2.2.

        SMAD4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of CACNA1B gene in HESC condition [11]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of CACNA1B gene in HESC condition, which leads to an increased expression of the drug transporter Voltage-gated calcium channel alpha Cav2.2.
References
1 N-type calcium channel v2.2 is a target of TCF21 in adrenocortical carcinomas. Neoplasma. 2022 Jul;69(4):899-908.
2 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
3 TWIST1 preserves hematopoietic stem cell function via the CACNA1B/Ca2+/mitochondria axis. Blood. 2021 May 27;137(21):2907-2919.
4 Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
5 Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor. PLoS One. 2011;6(1):e16344.
6 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
7 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
8 Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites. PLoS One. 2012;7(5):e36054.
9 An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 2011;147(1):132-46.
10 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
11 Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol. 2011;357(2):492-504.

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